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122 related items for PubMed ID: 2121734

  • 1. Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.
    Kadowaki T, Kadowaki H, Accili D, Taylor SI.
    J Biol Chem; 1990 Nov 05; 265(31):19143-50. PubMed ID: 2121734
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  • 2. Substitution of arginine for histidine at position 209 in the alpha-subunit of the human insulin receptor. A mutation that impairs receptor dimerization and transport of receptors to the cell surface.
    Kadowaki T, Kadowaki H, Accili D, Yazaki Y, Taylor SI.
    J Biol Chem; 1991 Nov 05; 266(31):21224-31. PubMed ID: 1657953
    [Abstract] [Full Text] [Related]

  • 3. Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites.
    Kadowaki H, Kadowaki T, Cama A, Marcus-Samuels B, Rovira A, Bevins CL, Taylor SI.
    J Biol Chem; 1990 Dec 05; 265(34):21285-96. PubMed ID: 2123490
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  • 6. Characterization of an insulin receptor mutant lacking the subunit processing site.
    Williams JF, McClain DA, Dull TJ, Ullrich A, Olefsky JM.
    J Biol Chem; 1990 May 25; 265(15):8463-9. PubMed ID: 2187866
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  • 7. Mutations in insulin-receptor gene in insulin-resistant patients.
    Taylor SI, Kadowaki T, Kadowaki H, Accili D, Cama A, McKeon C.
    Diabetes Care; 1990 Mar 25; 13(3):257-79. PubMed ID: 1968373
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  • 8. Mutation of the high cysteine region of the human insulin receptor alpha-subunit increases insulin receptor binding affinity and transmembrane signaling.
    Rafaeloff R, Patel R, Yip C, Goldfine ID, Hawley DM.
    J Biol Chem; 1989 Sep 25; 264(27):15900-4. PubMed ID: 2550426
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  • 10. Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.
    Cama A, Quon MJ, de la Luz Sierra M, Taylor SI.
    J Biol Chem; 1992 Apr 25; 267(12):8383-9. PubMed ID: 1314826
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  • 11. Substitution of glutamic acid for alanine 1135 in the putative "catalytic loop" of the tyrosine kinase domain of the human insulin receptor. A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity.
    Cama A, de la Luz Sierra M, Quon MJ, Ottini L, Gorden P, Taylor SI.
    J Biol Chem; 1993 Apr 15; 268(11):8060-9. PubMed ID: 8096518
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  • 12. Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.
    Wertheimer E, Barbetti F, Muggeo M, Roth J, Taylor SI.
    J Biol Chem; 1994 Mar 11; 269(10):7587-92. PubMed ID: 8125981
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  • 13. A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface.
    Maassen JA, Van der Vorm ER, Van der Zon GC, Klinkhamer MP, Krans HM, Möller W.
    Biochemistry; 1991 Nov 05; 30(44):10778-83. PubMed ID: 1931997
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  • 14. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.
    Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI.
    Biochemistry; 1995 Jul 25; 34(29):9341-9. PubMed ID: 7626603
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  • 15. Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: impaired insulin-stimulated c-jun expression and thymidine incorporation despite normal receptor autophosphorylation.
    Quon MJ, Cama A, Taylor SI.
    Biochemistry; 1992 Oct 20; 31(41):9947-54. PubMed ID: 1390778
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  • 16. Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells.
    Levy-Toledano R, Accili D, Taylor SI.
    Biochim Biophys Acta; 1993 Dec 16; 1220(1):1-14. PubMed ID: 8268238
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  • 17. A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.
    Accili D, Frapier C, Mosthaf L, McKeon C, Elbein SC, Permutt MA, Ramos E, Lander E, Ullrich A, Taylor SI.
    EMBO J; 1989 Sep 16; 8(9):2509-17. PubMed ID: 2573522
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  • 18. An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.
    van der Vorm ER, van der Zon GC, Möller W, Krans HM, Lindhout D, Maassen JA.
    J Biol Chem; 1992 Jan 05; 267(1):66-71. PubMed ID: 1730625
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  • 19. Deletion of 3 basepairs resulting in the loss of lysine-121 in the insulin receptor alpha-subunit in a patient with leprechaunism: binding, phosphorylation, and biological activity.
    Jospe N, Zhu J, Liu R, Livingston JN, Furlanetto RW.
    J Clin Endocrinol Metab; 1994 Nov 05; 79(5):1294-302. PubMed ID: 7962321
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  • 20. An insulin receptor mutant (Asp707 --> Ala), involved in leprechaunism, is processed and transported to the cell surface but unable to bind insulin.
    Hart LM, Lindhout D, Van der Zon GC, Kayserilli H, Apak MY, Kleijer WJ, Van der Vorm ER, Maassen JA.
    J Biol Chem; 1996 Aug 02; 271(31):18719-24. PubMed ID: 8702527
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