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387 related items for PubMed ID: 21224428

  • 1. Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.
    Juvekar A, Manna S, Ramaswami S, Chang TP, Vu HY, Ghosh CC, Celiker MY, Vancurova I.
    Mol Cancer Res; 2011 Feb; 9(2):183-94. PubMed ID: 21224428
    [Abstract] [Full Text] [Related]

  • 2. Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis.
    Sors A, Jean-Louis F, Pellet C, Laroche L, Dubertret L, Courtois G, Bachelez H, Michel L.
    Blood; 2006 Mar 15; 107(6):2354-63. PubMed ID: 16219794
    [Abstract] [Full Text] [Related]

  • 3. Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101.
    Duan J, Friedman J, Nottingham L, Chen Z, Ara G, Van Waes C.
    Mol Cancer Ther; 2007 Jan 15; 6(1):37-50. PubMed ID: 17237265
    [Abstract] [Full Text] [Related]

  • 4. Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells.
    Chang TP, Poltoratsky V, Vancurova I.
    J Immunol; 2015 Mar 15; 194(6):2942-53. PubMed ID: 25681335
    [Abstract] [Full Text] [Related]

  • 5. Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes.
    Shukla S, Gupta S.
    Clin Cancer Res; 2004 May 01; 10(9):3169-78. PubMed ID: 15131058
    [Abstract] [Full Text] [Related]

  • 6. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
    Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB.
    Cancer Res; 2005 Oct 15; 65(20):9555-65. PubMed ID: 16230421
    [Abstract] [Full Text] [Related]

  • 7. Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
    Sethi G, Ahn KS, Sung B, Aggarwal BB.
    Mol Cancer Ther; 2008 Jun 15; 7(6):1604-14. PubMed ID: 18566231
    [Abstract] [Full Text] [Related]

  • 8. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
    Hideshima T, Ikeda H, Chauhan D, Okawa Y, Raje N, Podar K, Mitsiades C, Munshi NC, Richardson PG, Carrasco RD, Anderson KC.
    Blood; 2009 Jul 30; 114(5):1046-52. PubMed ID: 19436050
    [Abstract] [Full Text] [Related]

  • 9. Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.
    Zhang JS, Herreros-Villanueva M, Koenig A, Deng Z, de Narvajas AA, Gomez TS, Meng X, Bujanda L, Ellenrieder V, Li XK, Kaufmann SH, Billadeau DD.
    Cell Death Dis; 2014 Mar 27; 5(3):e1142. PubMed ID: 24675460
    [Abstract] [Full Text] [Related]

  • 10. Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-κB activity in human oral cancer cells.
    Tamatani T, Takamaru N, Hara K, Kinouchi M, Kuribayashi N, Ohe G, Uchida D, Fujisawa K, Nagai H, Miyamoto Y.
    Int J Oncol; 2013 Mar 27; 42(3):935-44. PubMed ID: 23340716
    [Abstract] [Full Text] [Related]

  • 11. Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis.
    Denlinger CE, Rundall BK, Keller MD, Jones DR.
    Ann Thorac Surg; 2004 Oct 27; 78(4):1207-14; discussion 1207-14. PubMed ID: 15464472
    [Abstract] [Full Text] [Related]

  • 12. Proteasome inhibition as a novel mechanism of the proapoptotic activity of γ-secretase inhibitor I in cutaneous T-cell lymphoma.
    Biskup E, Kamstrup MR, Manfé V, Gniadecki R.
    Br J Dermatol; 2013 Mar 27; 168(3):504-12. PubMed ID: 23445313
    [Abstract] [Full Text] [Related]

  • 13. IKKβ inhibitor in combination with bortezomib induces cytotoxicity in breast cancer cells.
    Hideshima H, Yoshida Y, Ikeda H, Hide M, Iwasaki A, Anderson KC, Hideshima T.
    Int J Oncol; 2014 Apr 27; 44(4):1171-6. PubMed ID: 24481412
    [Abstract] [Full Text] [Related]

  • 14. Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.
    Sasaki CY, Barberi TJ, Ghosh P, Longo DL.
    J Biol Chem; 2005 Oct 14; 280(41):34538-47. PubMed ID: 16105840
    [Abstract] [Full Text] [Related]

  • 15. Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation.
    Li C, Chen S, Yue P, Deng X, Lonial S, Khuri FR, Sun SY.
    J Biol Chem; 2010 May 21; 285(21):16096-104. PubMed ID: 20335171
    [Abstract] [Full Text] [Related]

  • 16. Nitric oxide induces apoptosis in cutaneous T cell lymphoma (HuT-78) by downregulating constitutive NF-kappaB.
    Rishi L, Dhiman R, Raje M, Majumdar S.
    Biochim Biophys Acta; 2007 Aug 21; 1770(8):1230-9. PubMed ID: 17555878
    [Abstract] [Full Text] [Related]

  • 17. Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma.
    Bu R, Hussain AR, Al-Obaisi KA, Ahmed M, Uddin S, Al-Kuraya KS.
    Leuk Lymphoma; 2014 Feb 21; 55(2):415-24. PubMed ID: 23697845
    [Abstract] [Full Text] [Related]

  • 18. Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner.
    Lee KH, Jeong J, Yoo CG.
    J Biol Chem; 2013 Nov 08; 288(45):32777-32786. PubMed ID: 24085292
    [Abstract] [Full Text] [Related]

  • 19. Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
    Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB.
    Mol Cancer Ther; 2008 Oct 08; 7(10):3306-17. PubMed ID: 18852134
    [Abstract] [Full Text] [Related]

  • 20. Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer.
    Allen C, Saigal K, Nottingham L, Arun P, Chen Z, Van Waes C.
    Clin Cancer Res; 2008 Jul 01; 14(13):4175-85. PubMed ID: 18593997
    [Abstract] [Full Text] [Related]

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