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175 related items for PubMed ID: 2123741

  • 1. Activation of mitomycin C by NADPH:cytochrome P-450 reductase.
    Bligh HF, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR.
    Cancer Res; 1990 Dec 15; 50(24):7789-92. PubMed ID: 2123741
    [Abstract] [Full Text] [Related]

  • 2. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
    Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC.
    Cancer Res; 1984 Dec 15; 44(12 Pt 1):5638-43. PubMed ID: 6437671
    [Abstract] [Full Text] [Related]

  • 3. One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase.
    Vromans RM, van de Straat R, Groeneveld M, Vermeulen NP.
    Xenobiotica; 1990 Sep 15; 20(9):967-78. PubMed ID: 2122607
    [Abstract] [Full Text] [Related]

  • 4. Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
    Seow HA, Belcourt MF, Penketh PG, Hodnick WF, Tomasz M, Rockwell S, Sartorelli AC.
    Mol Pharmacol; 2005 Feb 15; 67(2):417-23. PubMed ID: 15547247
    [Abstract] [Full Text] [Related]

  • 5. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
    Fracasso PM, Sartorelli AC.
    Cancer Res; 1986 Aug 15; 46(8):3939-44. PubMed ID: 3089583
    [Abstract] [Full Text] [Related]

  • 6. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 15; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

  • 7. Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
    Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC.
    Cancer Res; 2001 Nov 01; 61(21):7770-6. PubMed ID: 11691791
    [Abstract] [Full Text] [Related]

  • 8. Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.
    Dulhanty AM, Whitmore GF.
    Cancer Res; 1991 Apr 01; 51(7):1860-5. PubMed ID: 1900739
    [Abstract] [Full Text] [Related]

  • 9. Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.
    Hoban PR, Walton MI, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID.
    Cancer Res; 1990 Aug 01; 50(15):4692-7. PubMed ID: 2114946
    [Abstract] [Full Text] [Related]

  • 10. Genetic variation of human cytochrome p450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity.
    Wang SL, Han JF, He XY, Wang XR, Hong JY.
    Drug Metab Dispos; 2007 Jan 01; 35(1):176-9. PubMed ID: 17062779
    [Abstract] [Full Text] [Related]

  • 11. Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.
    Hodnick WF, Sartorelli AC.
    Cancer Res; 1993 Oct 15; 53(20):4907-12. PubMed ID: 8402680
    [Abstract] [Full Text] [Related]

  • 12. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 1996 Jan 09; 93(1):456-60. PubMed ID: 8552660
    [Abstract] [Full Text] [Related]

  • 13. Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
    Keyes SR, Rockwell S, Sartorelli AC.
    Cancer Res; 1989 Jun 15; 49(12):3310-3. PubMed ID: 2470504
    [Abstract] [Full Text] [Related]

  • 14. Bioreduction of idarubicin and formation of ROS responsible for DNA cleavage by NADPH-cytochrome P450 reductase and its potential role in the antitumor effect.
    Celik H, Arinç E.
    J Pharm Pharm Sci; 2008 Jun 15; 11(4):68-82. PubMed ID: 19183515
    [Abstract] [Full Text] [Related]

  • 15. Characterization of a set of Chinese hamster ovary variant cell lines demonstrating differing sensitivity to mitomycin C.
    Kuehl BL, Buchwald M, Rauth AM.
    Oncol Res; 1993 Jun 15; 5(6-7):213-21. PubMed ID: 8123941
    [Abstract] [Full Text] [Related]

  • 16. [DT-diaphorase].
    Mikami K, Shirakusa T, Tsuruo T.
    Gan To Kagaku Ryoho; 1997 Sep 15; 24(11):1606-10. PubMed ID: 9309161
    [Abstract] [Full Text] [Related]

  • 17.
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  • 18. Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.
    Chun YJ, Shimada T, Guengerich FP.
    Arch Biochem Biophys; 1996 Jun 01; 330(1):48-58. PubMed ID: 8651703
    [Abstract] [Full Text] [Related]

  • 19. Cytochrome P450 reductase dependent inhibition of cytochrome P450 2B1 activity: Implications for gene directed enzyme prodrug therapy.
    Lengler J, Omann M, Düvier D, Holzmüller H, Gregor W, Salmons B, Günzburg WH, Renner M.
    Biochem Pharmacol; 2006 Sep 28; 72(7):893-901. PubMed ID: 16887103
    [Abstract] [Full Text] [Related]

  • 20. Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells.
    Marshall RS, Rauth AM.
    Cancer Res; 1988 Oct 15; 48(20):5655-9. PubMed ID: 3167822
    [Abstract] [Full Text] [Related]

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