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220 related items for PubMed ID: 21250978

  • 1. The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase.
    Park MT, Song MJ, Oh ET, Lee H, Choi BH, Jeong SY, Choi EK, Park HJ.
    Br J Pharmacol; 2011 Jun; 163(3):567-85. PubMed ID: 21250978
    [Abstract] [Full Text] [Related]

  • 2. β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells.
    Park MT, Song MJ, Lee H, Oh ET, Choi BH, Jeong SY, Choi EK, Park HJ.
    PLoS One; 2011 Jun; 6(10):e25976. PubMed ID: 21998736
    [Abstract] [Full Text] [Related]

  • 3. Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment.
    Lee H, Park MT, Choi BH, Oh ET, Song MJ, Lee J, Kim C, Lim BU, Park HJ.
    PLoS One; 2011 Jun; 6(6):e21533. PubMed ID: 21738692
    [Abstract] [Full Text] [Related]

  • 4. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).
    Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D.
    Mol Pharmacol; 2008 Dec; 74(6):1657-65. PubMed ID: 18794327
    [Abstract] [Full Text] [Related]

  • 5. Role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ.
    Nemeikaite-Ceniene A, Dringeliene A, Sarlauskas J, Cenas N.
    Acta Biochim Pol; 2005 Dec; 52(4):937-41. PubMed ID: 15940348
    [Abstract] [Full Text] [Related]

  • 6. RH1 induces cellular damage in an NAD(P)H:quinone oxidoreductase 1-dependent manner: relationship between DNA cross-linking, cell cycle perturbations, and apoptosis.
    Dehn DL, Inayat-Hussain SH, Ross D.
    J Pharmacol Exp Ther; 2005 May; 313(2):771-9. PubMed ID: 15665137
    [Abstract] [Full Text] [Related]

  • 7. Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo.
    Digby T, Leith MK, Thliveris JA, Begleiter A.
    Cancer Chemother Pharmacol; 2005 Sep; 56(3):307-16. PubMed ID: 15877230
    [Abstract] [Full Text] [Related]

  • 8. A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
    Winski SL, Hargreaves RH, Butler J, Ross D.
    Clin Cancer Res; 1998 Dec; 4(12):3083-8. PubMed ID: 9865924
    [Abstract] [Full Text] [Related]

  • 9. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
    Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D.
    Biochem Pharmacol; 2001 Jun 15; 61(12):1509-16. PubMed ID: 11377380
    [Abstract] [Full Text] [Related]

  • 10. Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.
    Dehn DL, Winski SL, Ross D.
    Clin Cancer Res; 2004 May 01; 10(9):3147-55. PubMed ID: 15131056
    [Abstract] [Full Text] [Related]

  • 11. Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
    Tudor G, Alley M, Nelson CM, Huang R, Covell DG, Gutierrez P, Sausville EA.
    Anticancer Drugs; 2005 Apr 01; 16(4):381-91. PubMed ID: 15746574
    [Abstract] [Full Text] [Related]

  • 12. Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
    Loadman PM, Phillips RM, Lim LE, Bibby MC.
    Biochem Pharmacol; 2000 Apr 01; 59(7):831-7. PubMed ID: 10718341
    [Abstract] [Full Text] [Related]

  • 13. Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
    Hussein D, Holt SV, Brookes KE, Klymenko T, Adamski JK, Hogg A, Estlin EJ, Ward T, Dive C, Makin GW.
    Br J Cancer; 2009 Jul 07; 101(1):55-63. PubMed ID: 19491903
    [Abstract] [Full Text] [Related]

  • 14. Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.
    Ward TH, Danson S, McGown AT, Ranson M, Coe NA, Jayson GC, Cummings J, Hargreaves RH, Butler J.
    Clin Cancer Res; 2005 Apr 01; 11(7):2695-701. PubMed ID: 15814651
    [Abstract] [Full Text] [Related]

  • 15. The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells.
    Hasinoff BB, Begleiter A.
    Free Radic Res; 2006 Sep 01; 40(9):974-8. PubMed ID: 17015278
    [Abstract] [Full Text] [Related]

  • 16. The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells.
    Kang YH, Lee SJ.
    J Cell Physiol; 2008 Oct 01; 217(1):23-33. PubMed ID: 18412143
    [Abstract] [Full Text] [Related]

  • 17. Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress.
    Nemeikaite-Ceniene A, Sarlauskas J, Anusevicius Z, Nivinskas H, Cenas N.
    Arch Biochem Biophys; 2003 Aug 01; 416(1):110-8. PubMed ID: 12859987
    [Abstract] [Full Text] [Related]

  • 18. c-Jun NH2-terminal kinase (JNK)-dependent nuclear translocation of apoptosis-inducing factor (AIF) following engagement of membrane immunoglobulin on WEHI-231 B lymphoma cells.
    Takada E, Hata K, Mizuguchi J.
    J Cell Biochem; 2008 Aug 01; 104(5):1927-36. PubMed ID: 18384124
    [Abstract] [Full Text] [Related]

  • 19. Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.
    Han X, Liu C, Zhang K, Guo M, Shen Z, Liu Y, Zuo Z, Cao M, Li Y.
    Toxicol Lett; 2018 Mar 15; 285():60-73. PubMed ID: 29289695
    [Abstract] [Full Text] [Related]

  • 20. Mycotoxin zearalenone induces AIF- and ROS-mediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages.
    Yu JY, Zheng ZH, Son YO, Shi X, Jang YO, Lee JC.
    Toxicol In Vitro; 2011 Dec 15; 25(8):1654-63. PubMed ID: 21767629
    [Abstract] [Full Text] [Related]

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