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Journal Abstract Search

141 related items for PubMed ID: 2125495

  • 1. A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant.
    Zhang L, Castellino FJ.
    Biochemistry; 1990 Dec 04; 29(48):10828-34. PubMed ID: 2125495
    [Abstract] [Full Text] [Related]

  • 2. Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity.
    Zhang L, Jhingan A, Castellino FJ.
    Blood; 1992 Aug 15; 80(4):942-52. PubMed ID: 1498334
    [Abstract] [Full Text] [Related]

  • 3. Role of the hexapeptide disulfide loop present in the gamma-carboxyglutamic acid domain of human protein C in its activation properties and in the in vitro anticoagulant activity of activated protein C.
    Zhang L, Castellino FJ.
    Biochemistry; 1991 Jul 09; 30(27):6696-704. PubMed ID: 1905953
    [Abstract] [Full Text] [Related]

  • 4. The activities of recombinant gamma-carboxyglutamic-acid-deficient mutants of activated human protein C toward human coagulation factor Va and factor VIII in purified systems and in plasma.
    Jhingan A, Zhang L, Christiansen WT, Castellino FJ.
    Biochemistry; 1994 Feb 22; 33(7):1869-75. PubMed ID: 8110790
    [Abstract] [Full Text] [Related]

  • 5. Properties of a recombinant chimeric protein in which the gamma-carboxyglutamic acid and helical stack domains of human anticoagulant protein C are replaced by those of human coagulation factor VII.
    Geng JP, Castellino FJ.
    Thromb Haemost; 1997 May 22; 77(5):926-33. PubMed ID: 9184404
    [Abstract] [Full Text] [Related]

  • 6. Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein c. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium.
    Christiansen WT, Tulinsky A, Castellino FJ.
    Biochemistry; 1994 Dec 20; 33(50):14993-5000. PubMed ID: 7999756
    [Abstract] [Full Text] [Related]

  • 7. Highly conserved residue arginine-15 is required for the Ca2+-dependent properties of the gamma-carboxyglutamic acid domain of human anticoagulation protein C and activated protein C.
    Thariath A, Castellino FJ.
    Biochem J; 1997 Feb 15; 322 ( Pt 1)(Pt 1):309-15. PubMed ID: 9078278
    [Abstract] [Full Text] [Related]

  • 8. Functional consequences of mutations in amino acid residues that stabilize calcium binding to the first epidermal growth factor homology domain of human protein C.
    Geng JP, Cheng CH, Castellino FJ.
    Thromb Haemost; 1996 Nov 15; 76(5):720-8. PubMed ID: 8950780
    [Abstract] [Full Text] [Related]

  • 9. Structure-function assessment of the role of the helical stack domain in the properties of human recombinant protein C and activated protein C.
    Christiansen WT, Geng JP, Castellino FJ.
    Biochemistry; 1995 Jun 27; 34(25):8082-90. PubMed ID: 7794921
    [Abstract] [Full Text] [Related]

  • 10. The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain.
    Zhang L, Castellino FJ.
    J Biol Chem; 1994 Feb 04; 269(5):3590-5. PubMed ID: 8106403
    [Abstract] [Full Text] [Related]

  • 11. Construction, expression, and properties of a recombinant chimeric human protein C with replacement of its growth factor-like domains by those of human coagulation factor IX.
    Yu S, Zhang L, Jhingan A, Christiansen WT, Castellino FJ.
    Biochemistry; 1994 Jan 25; 33(3):823-31. PubMed ID: 8292611
    [Abstract] [Full Text] [Related]

  • 12. Influence of specific gamma-carboxyglutamic acid residues on the integrity of the calcium-dependent conformation of human protein C.
    Zhang L, Castellino FJ.
    J Biol Chem; 1992 Dec 25; 267(36):26078-84. PubMed ID: 1464619
    [Abstract] [Full Text] [Related]

  • 13. The hydrophobic nature of residue-5 of human protein C is a major determinant of its functional interactions with acidic phospholipid vesicles.
    Jalbert LR, Chan JC, Christiansen WT, Castellino FJ.
    Biochemistry; 1996 Jun 04; 35(22):7093-9. PubMed ID: 8679535
    [Abstract] [Full Text] [Related]

  • 14. Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.
    Sun YH, Shen L, Dahlbäck B.
    Blood; 2003 Mar 15; 101(6):2277-84. PubMed ID: 12446455
    [Abstract] [Full Text] [Related]

  • 15. The functions of the first epidermal growth factor homology region of human protein C as revealed by a charge-to-alanine scanning mutagenesis investigation.
    Cheng CH, Geng JP, Castellino FJ.
    Biol Chem; 1997 Dec 15; 378(12):1491-500. PubMed ID: 9461348
    [Abstract] [Full Text] [Related]

  • 16. Properties of recombinant chimeric human protein C and activated protein C containing the gamma-carboxyglutamic acid and trailing helical stack domains of protein C replaced by those of human coagulation factor IX.
    Christiansen WT, Castellino FJ.
    Biochemistry; 1994 May 17; 33(19):5901-11. PubMed ID: 8180219
    [Abstract] [Full Text] [Related]

  • 17. The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles.
    Zhang L, Castellino FJ.
    J Biol Chem; 1993 Jun 05; 268(16):12040-5. PubMed ID: 8505327
    [Abstract] [Full Text] [Related]

  • 18. Hydrophobic amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid Vesicles.
    Christiansen WT, Jalbert LR, Robertson RM, Jhingan A, Prorok M, Castellino FJ.
    Biochemistry; 1995 Aug 22; 34(33):10376-82. PubMed ID: 7654691
    [Abstract] [Full Text] [Related]

  • 19. Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors.
    Rezaie AR, Esmon CT.
    J Biol Chem; 1993 Sep 25; 268(27):19943-8. PubMed ID: 8104182
    [Abstract] [Full Text] [Related]

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