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Journal Abstract Search

362 related items for PubMed ID: 21303903

  • 1. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
    Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.
    J Biol Chem; 2011 Apr 08; 286(14):12743-55. PubMed ID: 21303903
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  • 4. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells.
    Chien W, Ding LW, Sun QY, Torres-Fernandez LA, Tan SZ, Xiao J, Lim SL, Garg M, Lee KL, Kitajima S, Takao S, Leong WZ, Sun H, Tokatly I, Poellinger L, Gery S, Koeffler PH.
    Oncotarget; 2014 Jul 15; 5(13):4881-94. PubMed ID: 24952679
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  • 5. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
    Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D.
    Nature; 2002 Jan 03; 415(6867):92-6. PubMed ID: 11780124
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  • 6. PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.
    Eletto D, Eletto D, Boyle S, Argon Y.
    FASEB J; 2016 Feb 03; 30(2):653-65. PubMed ID: 26487694
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  • 7. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
    Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP.
    Proc Natl Acad Sci U S A; 2012 Apr 10; 109(15):E869-78. PubMed ID: 22315414
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  • 9. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
    Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F.
    Nat Commun; 2014 Aug 28; 5():4202. PubMed ID: 25164867
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  • 10. Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production.
    Kim S, Joe Y, Kim HJ, Kim YS, Jeong SO, Pae HO, Ryter SW, Surh YJ, Chung HT.
    J Immunol; 2015 May 01; 194(9):4498-506. PubMed ID: 25821218
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  • 11. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
    Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.
    Blood; 2012 Jun 14; 119(24):5772-81. PubMed ID: 22538852
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  • 12. Phosphoregulation of Ire1 RNase splicing activity.
    Prischi F, Nowak PR, Carrara M, Ali MM.
    Nat Commun; 2014 Apr 07; 5():3554. PubMed ID: 24704861
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  • 13. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
    Tang CH, Ranatunga S, Kriss CL, Cubitt CL, Tao J, Pinilla-Ibarz JA, Del Valle JR, Hu CC.
    J Clin Invest; 2014 Jun 07; 124(6):2585-98. PubMed ID: 24812669
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  • 14. Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.
    Benhamron S, Hadar R, Iwawaky T, So JS, Lee AH, Tirosh B.
    Eur J Immunol; 2014 Mar 07; 44(3):867-76. PubMed ID: 24242955
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  • 15. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.
    Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH.
    Proc Natl Acad Sci U S A; 2003 Aug 19; 100(17):9946-51. PubMed ID: 12902539
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  • 16. Principles of IRE1 modulation using chemical tools.
    Lee KP, Sicheri F.
    Methods Enzymol; 2011 Aug 19; 490():271-94. PubMed ID: 21266256
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  • 17. Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response.
    Zheng Y, Gao B, Ye L, Kong L, Jing W, Yang X, Wu Z, Ye L.
    J Microbiol; 2005 Dec 19; 43(6):529-36. PubMed ID: 16410770
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  • 18. The molecular mechanism and functional diversity of UPR signaling sensor IRE1.
    Bashir S, Banday M, Qadri O, Bashir A, Hilal N, Nida-I-Fatima, Rader S, Fazili KM.
    Life Sci; 2021 Jan 15; 265():118740. PubMed ID: 33188833
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  • 19. Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.
    Back SH, Lee K, Vink E, Kaufman RJ.
    J Biol Chem; 2006 Jul 07; 281(27):18691-706. PubMed ID: 16644724
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  • 20. Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
    Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL.
    J Biomol Screen; 2013 Mar 07; 18(3):298-308. PubMed ID: 23139381
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