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229 related items for PubMed ID: 21304979

  • 1. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.
    Ghavami S, Mutawe MM, Sharma P, Yeganeh B, McNeill KD, Klonisch T, Unruh H, Kashani HH, Schaafsma D, Los M, Halayko AJ.
    PLoS One; 2011 Jan 31; 6(1):e16523. PubMed ID: 21304979
    [Abstract] [Full Text] [Related]

  • 2. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.
    Ghavami S, Sharma P, Yeganeh B, Ojo OO, Jha A, Mutawe MM, Kashani HH, Los MJ, Klonisch T, Unruh H, Halayko AJ.
    Biochim Biophys Acta; 2014 Jul 31; 1843(7):1259-71. PubMed ID: 24637330
    [Abstract] [Full Text] [Related]

  • 3. Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.
    Ghavami S, Mutawe MM, Hauff K, Stelmack GL, Schaafsma D, Sharma P, McNeill KD, Hynes TS, Kung SK, Unruh H, Klonisch T, Hatch GM, Los M, Halayko AJ.
    Biochim Biophys Acta; 2010 Apr 31; 1803(4):452-67. PubMed ID: 20045437
    [Abstract] [Full Text] [Related]

  • 4. Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
    Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ.
    Am J Physiol Lung Cell Mol Physiol; 2012 Feb 15; 302(4):L420-8. PubMed ID: 22160308
    [Abstract] [Full Text] [Related]

  • 5. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.
    Ghavami S, Yeganeh B, Stelmack GL, Kashani HH, Sharma P, Cunnington R, Rattan S, Bathe K, Klonisch T, Dixon IM, Freed DH, Halayko AJ.
    Cell Death Dis; 2012 Jun 21; 3(6):e330. PubMed ID: 22717585
    [Abstract] [Full Text] [Related]

  • 6. p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions.
    Garufi A, Pistritto G, Baldari S, Toietta G, Cirone M, D'Orazi G.
    J Exp Clin Cancer Res; 2017 Sep 11; 36(1):126. PubMed ID: 28893313
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of AMPK-dependent autophagy enhances in vitro antiglioma effect of simvastatin.
    Misirkic M, Janjetovic K, Vucicevic L, Tovilovic G, Ristic B, Vilimanovich U, Harhaji-Trajkovic L, Sumarac-Dumanovic M, Micic D, Bumbasirevic V, Trajkovic V.
    Pharmacol Res; 2012 Jan 11; 65(1):111-9. PubMed ID: 21871960
    [Abstract] [Full Text] [Related]

  • 8. Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma.
    Gu W, Cui R, Ding T, Li X, Peng J, Xu W, Han F, Guo X.
    Respirology; 2017 Apr 11; 22(3):533-541. PubMed ID: 27782356
    [Abstract] [Full Text] [Related]

  • 9. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.
    Blanco-Colio LM, Villa A, Ortego M, Hernández-Presa MA, Pascual A, Plaza JJ, Egido J.
    Atherosclerosis; 2002 Mar 11; 161(1):17-26. PubMed ID: 11882313
    [Abstract] [Full Text] [Related]

  • 10. Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
    Alizadeh J, Zeki AA, Mirzaei N, Tewary S, Rezaei Moghadam A, Glogowska A, Nagakannan P, Eftekharpour E, Wiechec E, Gordon JW, Xu FY, Field JT, Yoneda KY, Kenyon NJ, Hashemi M, Hatch GM, Hombach-Klonisch S, Klonisch T, Ghavami S.
    Sci Rep; 2017 Mar 27; 7():44841. PubMed ID: 28344327
    [Abstract] [Full Text] [Related]

  • 11. Preclinical evaluation of statins as a treatment for ovarian cancer.
    Robinson E, Nandi M, Wilkinson LL, Arrowsmith DM, Curtis AD, Richardson A.
    Gynecol Oncol; 2013 May 27; 129(2):417-24. PubMed ID: 23402903
    [Abstract] [Full Text] [Related]

  • 12. Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo.
    Pereira M, Glogova A, Haagsma J, Stewart J, Shepherd TG, Petrik J.
    J Ovarian Res; 2023 Nov 20; 16(1):218. PubMed ID: 37986175
    [Abstract] [Full Text] [Related]

  • 13. p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms.
    Wang Y, Dong XX, Cao Y, Liang ZQ, Han R, Wu JC, Gu ZL, Qin ZH.
    Eur J Neurosci; 2009 Dec 20; 30(12):2258-70. PubMed ID: 20092569
    [Abstract] [Full Text] [Related]

  • 14. Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade.
    Chang HL, Chen CY, Hsu YF, Kuo WS, Ou G, Chiu PT, Huang YH, Hsu MJ.
    Biochim Biophys Acta; 2013 Aug 20; 1830(8):4053-64. PubMed ID: 23583370
    [Abstract] [Full Text] [Related]

  • 15. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways.
    Kotamraju S, Williams CL, Kalyanaraman B.
    Cancer Res; 2007 Aug 01; 67(15):7386-94. PubMed ID: 17671209
    [Abstract] [Full Text] [Related]

  • 16. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.
    Tanaka T, Tatsuno I, Uchida D, Moroo I, Morio H, Nakamura S, Noguchi Y, Yasuda T, Kitagawa M, Saito Y, Hirai A.
    J Neurosci; 2000 Apr 15; 20(8):2852-9. PubMed ID: 10751437
    [Abstract] [Full Text] [Related]

  • 17. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum.
    Zhang XD, Wang Y, Wang Y, Zhang X, Han R, Wu JC, Liang ZQ, Gu ZL, Han F, Fukunaga K, Qin ZH.
    Autophagy; 2009 Apr 15; 5(3):339-50. PubMed ID: 19305162
    [Abstract] [Full Text] [Related]

  • 18. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.
    Kato S, Smalley S, Sadarangani A, Chen-Lin K, Oliva B, Brañes J, Carvajal J, Gejman R, Owen GI, Cuello M.
    J Cell Mol Med; 2010 May 15; 14(5):1180-93. PubMed ID: 19432822
    [Abstract] [Full Text] [Related]

  • 19. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells.
    Lee HY, Oh SH.
    Biochem Biophys Res Commun; 2021 Jan 01; 534():128-133. PubMed ID: 33321290
    [Abstract] [Full Text] [Related]

  • 20. Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis.
    Zhu BS, Xing CG, Lin F, Fan XQ, Zhao K, Qin ZH.
    World J Gastroenterol; 2011 Jan 28; 17(4):478-87. PubMed ID: 21274377
    [Abstract] [Full Text] [Related]

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