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Journal Abstract Search

153 related items for PubMed ID: 21333408

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  • 3. Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM.
    J Med Chem; 2011 Dec 08; 54(23):8161-73. PubMed ID: 22029285
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  • 4. (3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.
    Ivachtchenko AV, Dmitriev DE, Golovina ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Okun IM, Tkachenko SE, Vorobiev AA.
    J Med Chem; 2010 Jul 22; 53(14):5186-96. PubMed ID: 20560595
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  • 6. Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists.
    Ivachtchenko AV, Dmitriev DE, Golovina ES, Dubrovskaya ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM, Vorobiov AA.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2133-6. PubMed ID: 20207539
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  • 7. Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
    Baraldi PG, Fruttarolo F, Tabrizi MA, Preti D, Romagnoli R, El-Kashef H, Moorman A, Varani K, Gessi S, Merighi S, Borea PA.
    J Med Chem; 2003 Mar 27; 46(7):1229-41. PubMed ID: 12646033
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  • 10. Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
    Huang CQ, Wilcoxen KM, Grigoriadis DE, McCarthy JR, Chen C.
    Bioorg Med Chem Lett; 2004 Aug 02; 14(15):3943-7. PubMed ID: 15225703
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  • 11. The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
    Cheong SL, Dolzhenko A, Kachler S, Paoletta S, Federico S, Cacciari B, Dolzhenko A, Klotz KN, Moro S, Spalluto G, Pastorin G.
    J Med Chem; 2010 Apr 22; 53(8):3361-75. PubMed ID: 20307065
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  • 12. Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Kovalenko SM, Mitkin OD, Okun IM, Ravnyeyko IM, Tkachenko SE, Zaremba OV.
    Bioorg Med Chem; 2010 Jul 15; 18(14):5282-90. PubMed ID: 20541425
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  • 13. 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.
    Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM.
    Eur J Med Chem; 2010 Feb 15; 45(2):782-9. PubMed ID: 19939513
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  • 14. 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators.
    Bernotas RC, Antane S, Shenoy R, Le VD, Chen P, Harrison BL, Robichaud AJ, Zhang GM, Smith D, Schechter LE.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1657-60. PubMed ID: 20138763
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  • 15. 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
    Lenzi O, Colotta V, Catarzi D, Varano F, Poli D, Filacchioni G, Varani K, Vincenzi F, Borea PA, Paoletta S, Morizzo E, Moro S.
    J Med Chem; 2009 Dec 10; 52(23):7640-52. PubMed ID: 19743865
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  • 17. Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
    Pastorin G, Da Ros T, Spalluto G, Deflorian F, Moro S, Cacciari B, Baraldi PG, Gessi S, Varani K, Borea PA.
    J Med Chem; 2003 Sep 25; 46(20):4287-96. PubMed ID: 13678407
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  • 18. Synthesis and biological evaluation of benzoisothiazole derivatives possessing N,N-dimethylformimidamide group as 5-HT₆ receptor antagonists.
    Yoo E, Hayat F, Rhim H, Park Choo HY.
    Bioorg Med Chem; 2012 Apr 15; 20(8):2707-12. PubMed ID: 22405919
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  • 20. Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.
    Qi J, Zhang F, Mi Y, Fu Y, Xu W, Zhang D, Wu Y, Du X, Jia Q, Wang K, Zhang H.
    Eur J Med Chem; 2011 Mar 15; 46(3):934-43. PubMed ID: 21296466
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