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338 related items for PubMed ID: 21335601

  • 1. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
    Humnabadkar V, Jha RK, Ghatnekar N, De Sousa SM.
    J Biomol Screen; 2011 Mar; 16(3):303-12. PubMed ID: 21335601
    [Abstract] [Full Text] [Related]

  • 2. High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.
    Gottlin EB, Benson RE, Conary S, Antonio B, Duke K, Payne ES, Ashraf SS, Christensen DJ.
    J Biomol Screen; 2003 Jun; 8(3):332-9. PubMed ID: 12857387
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Woo YH, Fernandes RP, Proteau PJ.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2375-85. PubMed ID: 16310360
    [Abstract] [Full Text] [Related]

  • 4. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
    Proteau PJ.
    Bioorg Chem; 2004 Dec 01; 32(6):483-93. PubMed ID: 15530989
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  • 5. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Andaloussi M, Henriksson LM, Więckowska A, Lindh M, Björkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed M, Jones TA, Karlén A.
    J Med Chem; 2011 Jul 28; 54(14):4964-76. PubMed ID: 21678907
    [Abstract] [Full Text] [Related]

  • 6. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Mercklé L, de Andrés-Gómez A, Dick B, Cox RJ, Godfrey CR.
    Chembiochem; 2005 Oct 28; 6(10):1866-74. PubMed ID: 16116659
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  • 7. Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
    Giessmann D, Heidler P, Haemers T, Van Calenbergh S, Reichenberg A, Jomaa H, Weidemeyer C, Sanderbrand S, Wiesner J, Link A.
    Chem Biodivers; 2008 Apr 28; 5(4):643-56. PubMed ID: 18421757
    [Abstract] [Full Text] [Related]

  • 8. Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
    Ortmann R, Wiesner J, Silber K, Klebe G, Jomaa H, Schlitzer M.
    Arch Pharm (Weinheim); 2007 Sep 28; 340(9):483-90. PubMed ID: 17806130
    [Abstract] [Full Text] [Related]

  • 9. Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.
    Singh VK, Ghosh I.
    FEBS Lett; 2013 Sep 02; 587(17):2806-17. PubMed ID: 23816706
    [Abstract] [Full Text] [Related]

  • 10. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.
    Dhiman RK, Schaeffer ML, Bailey AM, Testa CA, Scherman H, Crick DC.
    J Bacteriol; 2005 Dec 02; 187(24):8395-402. PubMed ID: 16321944
    [Abstract] [Full Text] [Related]

  • 11. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
    Mac Sweeney A, Lange R, Fernandes RP, Schulz H, Dale GE, Douangamath A, Proteau PJ, Oefner C.
    J Mol Biol; 2005 Jan 07; 345(1):115-27. PubMed ID: 15567415
    [Abstract] [Full Text] [Related]

  • 12. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.
    Zinglé C, Kuntz L, Tritsch D, Grosdemange-Billiard C, Rohmer M.
    J Org Chem; 2010 May 21; 75(10):3203-7. PubMed ID: 20429517
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  • 16. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
    Takenoya M, Ohtaki A, Noguchi K, Endo K, Sasaki Y, Ohsawa K, Yajima S, Yohda M.
    J Struct Biol; 2010 Jun 21; 170(3):532-9. PubMed ID: 20353826
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  • 19. Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Munos JW, Pu X, Liu HW.
    Bioorg Med Chem Lett; 2008 May 15; 18(10):3090-4. PubMed ID: 18078746
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  • 20. Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
    Yajima S, Hara K, Sanders JM, Yin F, Ohsawa K, Wiesner J, Jomaa H, Oldfield E.
    J Am Chem Soc; 2004 Sep 08; 126(35):10824-5. PubMed ID: 15339150
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