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759 related items for PubMed ID: 21335603

  • 1. Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.
    Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.
    Carcinogenesis; 2011 May; 32(5):703-12. PubMed ID: 21335603
    [Abstract] [Full Text] [Related]

  • 2. Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
    Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H.
    Mol Pharmacol; 2008 Jul; 74(1):236-45. PubMed ID: 18426857
    [Abstract] [Full Text] [Related]

  • 3. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.
    Biochem J; 2004 Aug 01; 381(Pt 3):761-7. PubMed ID: 15104534
    [Abstract] [Full Text] [Related]

  • 4. Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.
    Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.
    J Cell Sci; 2012 Nov 01; 125(Pt 21):5168-76. PubMed ID: 22946054
    [Abstract] [Full Text] [Related]

  • 5. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
    Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM.
    BMC Cancer; 2012 Jul 17; 12():293. PubMed ID: 22804960
    [Abstract] [Full Text] [Related]

  • 6. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.
    Han WQ, Zhu Q, Hu J, Li PL, Zhang F, Li N.
    Biochim Biophys Acta; 2013 Jun 17; 1833(6):1454-62. PubMed ID: 23466866
    [Abstract] [Full Text] [Related]

  • 7. Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.
    Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang LE.
    FASEB J; 2004 Jun 17; 18(9):1028-30. PubMed ID: 15084514
    [Abstract] [Full Text] [Related]

  • 8. NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity.
    Li YN, Xi MM, Guo Y, Hai CX, Yang WL, Qin XJ.
    Toxicol Lett; 2014 Jan 13; 224(2):165-74. PubMed ID: 24188932
    [Abstract] [Full Text] [Related]

  • 9. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
    Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.
    EMBO J; 2003 Aug 15; 22(16):4082-90. PubMed ID: 12912907
    [Abstract] [Full Text] [Related]

  • 10. Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.
    Spinella F, Rosanò L, Del Duca M, Di Castro V, Nicotra MR, Natali PG, Bagnato A.
    PLoS One; 2010 Jun 21; 5(6):e11241. PubMed ID: 20574527
    [Abstract] [Full Text] [Related]

  • 11. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
    Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q.
    PLoS One; 2014 Jun 21; 9(11):e113865. PubMed ID: 25420025
    [Abstract] [Full Text] [Related]

  • 12. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
    Hewitson KS, Schofield CJ, Ratcliffe PJ.
    Methods Enzymol; 2007 Jun 21; 435():25-42. PubMed ID: 17998047
    [Abstract] [Full Text] [Related]

  • 13. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.
    Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.
    J Cell Biochem; 2004 Jun 01; 92(3):491-501. PubMed ID: 15156561
    [Abstract] [Full Text] [Related]

  • 14. The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.
    Choi SM, Choi KO, Lee N, Oh M, Park H.
    Biochem Biophys Res Commun; 2006 May 19; 343(4):1002-8. PubMed ID: 16579968
    [Abstract] [Full Text] [Related]

  • 15. Hypoxia-inducible factors in the first trimester human lung.
    Groenman F, Rutter M, Caniggia I, Tibboel D, Post M.
    J Histochem Cytochem; 2007 Apr 19; 55(4):355-63. PubMed ID: 17189520
    [Abstract] [Full Text] [Related]

  • 16. Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla.
    Wang Z, Zhu Q, Xia M, Li PL, Hinton SJ, Li N.
    Hypertension; 2010 May 19; 55(5):1129-36. PubMed ID: 20308610
    [Abstract] [Full Text] [Related]

  • 17. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
    Flashman E, Davies SL, Yeoh KK, Schofield CJ.
    Biochem J; 2010 Mar 15; 427(1):135-42. PubMed ID: 20055761
    [Abstract] [Full Text] [Related]

  • 18. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.
    Huang J, Zhao Q, Mooney SM, Lee FS.
    J Biol Chem; 2002 Oct 18; 277(42):39792-800. PubMed ID: 12181324
    [Abstract] [Full Text] [Related]

  • 19. Increased activation of the hypoxia-inducible factor pathway in varicose veins.
    Lim CS, Kiriakidis S, Paleolog EM, Davies AH.
    J Vasc Surg; 2012 May 18; 55(5):1427-39. PubMed ID: 22277691
    [Abstract] [Full Text] [Related]

  • 20. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
    Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.
    Mol Cell; 2005 Feb 18; 17(4):503-12. PubMed ID: 15721254
    [Abstract] [Full Text] [Related]

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