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Journal Abstract Search

513 related items for PubMed ID: 21338440

  • 1. Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer.
    Onishi H, Kai M, Odate S, Iwasaki H, Morifuji Y, Ogino T, Morisaki T, Nakashima Y, Katano M.
    Cancer Sci; 2011 Jun; 102(6):1144-50. PubMed ID: 21338440
    [Abstract] [Full Text] [Related]

  • 2. Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer.
    Onishi H, Yamasaki A, Kawamoto M, Imaizumi A, Katano M.
    Cancer Lett; 2016 Feb 28; 371(2):143-50. PubMed ID: 26655998
    [Abstract] [Full Text] [Related]

  • 3. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.
    Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M.
    Clin Cancer Res; 2010 Mar 15; 16(6):1781-9. PubMed ID: 20215540
    [Abstract] [Full Text] [Related]

  • 4. Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner.
    Lei J, Ma J, Ma Q, Li X, Liu H, Xu Q, Duan W, Sun Q, Xu J, Wu Z, Wu E.
    Mol Cancer; 2013 Jun 20; 12():66. PubMed ID: 23786654
    [Abstract] [Full Text] [Related]

  • 5. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
    Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D.
    Genes Dev; 2009 Jan 01; 23(1):24-36. PubMed ID: 19136624
    [Abstract] [Full Text] [Related]

  • 6. Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling.
    Morifuji Y, Onishi H, Iwasaki H, Imaizumi A, Nakano K, Tanaka M, Katano M.
    Cancer Sci; 2014 Mar 01; 105(3):324-33. PubMed ID: 24397700
    [Abstract] [Full Text] [Related]

  • 7. Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
    Onishi H, Morifuji Y, Kai M, Suyama K, Iwasaki H, Katano M.
    Cancer Sci; 2012 Jul 01; 103(7):1272-9. PubMed ID: 22486854
    [Abstract] [Full Text] [Related]

  • 8. Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia.
    Onishi H, Morisaki T, Nakao F, Odate S, Morisaki T, Katano M.
    Cancer Lett; 2013 Jul 28; 335(2):289-98. PubMed ID: 23485726
    [Abstract] [Full Text] [Related]

  • 9. Sonic hedgehog and Gli1 expression predict outcome in resected pancreatic adenocarcinoma.
    Maréchal R, Bachet JB, Calomme A, Demetter P, Delpero JR, Svrcek M, Cros J, Bardier-Dupas A, Puleo F, Monges G, Hammel P, Louvet C, Paye F, Bachelier P, Le Treut YP, Vaillant JC, Sauvanet A, André T, Salmon I, Devière J, Emile JF, Van Laethem JL.
    Clin Cancer Res; 2015 Mar 01; 21(5):1215-24. PubMed ID: 25552484
    [Abstract] [Full Text] [Related]

  • 10. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.
    Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.
    Cancer Lett; 2013 Oct 10; 339(2):185-94. PubMed ID: 23791879
    [Abstract] [Full Text] [Related]

  • 11. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.
    Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.
    J Steroid Biochem Mol Biol; 2014 Jan 10; 139():7-15. PubMed ID: 24063979
    [Abstract] [Full Text] [Related]

  • 12. Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
    Xu X, Liu H, Zhang H, Dai W, Guo C, Xie C, Wei S, He S, Xu X.
    Pancreas; 2015 Nov 10; 44(8):1252-8. PubMed ID: 26465952
    [Abstract] [Full Text] [Related]

  • 13. Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway.
    Cao L, Xiao X, Lei J, Duan W, Ma Q, Li W.
    Oncol Rep; 2016 Jun 10; 35(6):3728-34. PubMed ID: 27035865
    [Abstract] [Full Text] [Related]

  • 14. Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.
    Yao J, An Y, Wie JS, Ji ZL, Lu ZP, Wu JL, Jiang KR, Chen P, Xu ZK, Miao Y.
    Swiss Med Wkly; 2011 Jun 10; 141():w13208. PubMed ID: 21630164
    [Abstract] [Full Text] [Related]

  • 15. LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.
    Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.
    PLoS One; 2013 Jun 10; 8(7):e67431. PubMed ID: 23861764
    [Abstract] [Full Text] [Related]

  • 16. Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2.
    Inaguma S, Ito H, Riku M, Ikeda H, Kasai K.
    Oncotarget; 2015 Sep 29; 6(29):28257-68. PubMed ID: 26318045
    [Abstract] [Full Text] [Related]

  • 17. Hedgehog Signaling Pathway Proteins in Prognosis of Pancreatic Ductal Adenocarcinoma and Its Differentiation From Chronic Pancreatitis.
    Winter K, Dzieniecka M, Strzelczyk J, Wągrowska-Danilewicz M, Danilewicz M, Zatorski H, Małecka-Wojciesko E.
    Pancreas; 2022 Mar 01; 51(3):219-227. PubMed ID: 35584378
    [Abstract] [Full Text] [Related]

  • 18. Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment.
    Huang Y, Nahar S, Nakagawa A, Fernandez-Barrena MG, Mertz JA, Bryant BM, Adams CE, Mino-Kenudson M, Von Alt KN, Chang K, Conery AR, Hatton C, Sims RJ, Fernandez-Zapico ME, Wang X, Lillemoe KD, Fernández-Del Castillo C, Warshaw AL, Thayer SP, Liss AS.
    Clin Cancer Res; 2016 Aug 15; 22(16):4259-70. PubMed ID: 27169995
    [Abstract] [Full Text] [Related]

  • 19. Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation.
    Li L, Bao J, Wang H, Lei JH, Peng C, Zeng J, Hao W, Zhang X, Xu X, Yu C, Deng CX, Chen Q.
    Theranostics; 2021 Aug 15; 11(4):1672-1689. PubMed ID: 33408774
    [Abstract] [Full Text] [Related]

  • 20. The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.
    He M, Fu Y, Yan Y, Xiao Q, Wu H, Yao W, Zhao H, Zhao L, Jiang Q, Yu Z, Jin F, Mi X, Wang E, Cui Z, Fu L, Chen J, Wei M.
    Clin Sci (Lond); 2015 Nov 15; 129(9):809-22. PubMed ID: 26201092
    [Abstract] [Full Text] [Related]

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