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Journal Abstract Search

71 related items for PubMed ID: 2134669

  • 1. DNA-glutathione adducts derived from vic-dihaloalkanes: mechanisms of mutagenesis.
    Guengerich FP, Humphreys WG, Kim DH, Oida T, Cmarik JL.
    Princess Takamatsu Symp; 1990; 21():101-7. PubMed ID: 2134669
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of oligonucleotides containing the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione at a single site.
    Kim MS, Guengerich FP.
    Chem Res Toxicol; 1997 Oct; 10(10):1133-43. PubMed ID: 9348436
    [Abstract] [Full Text] [Related]

  • 3. Covalent binding of 1,2-dihaloalkanes to DNA and stability of the major DNA adduct, S-[2-(N7-guanyl)ethyl]glutathione.
    Inskeep PB, Koga N, Cmarik JL, Guengerich FP.
    Cancer Res; 1986 Jun; 46(6):2839-44. PubMed ID: 2870801
    [Abstract] [Full Text] [Related]

  • 4. Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide.
    Cmarik JL, Humphreys WG, Bruner KL, Lloyd RS, Tibbetts C, Guengerich FP.
    J Biol Chem; 1992 Apr 05; 267(10):6672-9. PubMed ID: 1551876
    [Abstract] [Full Text] [Related]

  • 5. Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione.
    Kim MS, Guengerich FP.
    Chem Res Toxicol; 1998 Apr 05; 11(4):311-6. PubMed ID: 9548801
    [Abstract] [Full Text] [Related]

  • 6. Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes.
    Cmarik JL, Inskeep PB, Meredith MJ, Meyer DJ, Ketterer B, Guengerich FP.
    Cancer Res; 1990 May 01; 50(9):2747-52. PubMed ID: 2328501
    [Abstract] [Full Text] [Related]

  • 7. Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetylcysteine in urine following administration of ethylene dibromide to rats.
    Kim DH, Guengerich FP.
    Cancer Res; 1989 Nov 01; 49(21):5843-7. PubMed ID: 2790795
    [Abstract] [Full Text] [Related]

  • 8. Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation.
    Kim DH, Guengerich FP.
    Carcinogenesis; 1990 Mar 01; 11(3):419-24. PubMed ID: 2311185
    [Abstract] [Full Text] [Related]

  • 9. Characterization of S-[2-(N1-adenyl)ethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane.
    Kim DH, Humphreys WG, Guengerich FP.
    Chem Res Toxicol; 1990 Mar 01; 3(6):587-94. PubMed ID: 1715767
    [Abstract] [Full Text] [Related]

  • 10. Interactions of N7-guanyl methyl- and thioether-substituted d(CATGCCT) derivatives with d(AGGNATG).
    Kim MS, Guengerich FP.
    Chem Res Toxicol; 1993 Mar 01; 6(6):900-5. PubMed ID: 8117931
    [Abstract] [Full Text] [Related]

  • 11. Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane.
    Humphreys WG, Kim DH, Guengerich FP.
    Chem Res Toxicol; 1991 Mar 01; 4(4):445-53. PubMed ID: 1912332
    [Abstract] [Full Text] [Related]

  • 12. Effects of adduct formation derived from ethylene dibromide on DNA conformation.
    Oida T, Humphreys WG, Guengerich FP.
    Nucleic Acids Symp Ser; 1991 Mar 01; (25):135-6. PubMed ID: 1842056
    [Abstract] [Full Text] [Related]

  • 13. Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives.
    Humphreys WG, Kim DH, Cmarik JL, Shimada T, Guengerich FP.
    Biochemistry; 1990 Nov 13; 29(45):10342-50. PubMed ID: 2261477
    [Abstract] [Full Text] [Related]

  • 14. Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements.
    Persmark M, Guengerich FP.
    Biochemistry; 1994 Jul 26; 33(29):8662-72. PubMed ID: 8038155
    [Abstract] [Full Text] [Related]

  • 15. The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity.
    Powley MW, Walker VE, Li Y, Upton PB, Swenberg JA.
    Chem Biol Interact; 2007 Mar 20; 166(1-3):182-90. PubMed ID: 17349618
    [Abstract] [Full Text] [Related]

  • 16. Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts.
    Guengerich FP, Peterson LA, Cmarik JL, Koga N, Inskeep PB.
    Environ Health Perspect; 1987 Dec 20; 76():15-8. PubMed ID: 3329096
    [Abstract] [Full Text] [Related]

  • 17. Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver.
    Chung FL, Komninou D, Zhang L, Nath R, Pan J, Amin S, Richie J.
    Chem Res Toxicol; 2005 Jan 20; 18(1):24-7. PubMed ID: 15651845
    [Abstract] [Full Text] [Related]

  • 18. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
    Beland FA.
    Toxic Rep Ser; 1999 Aug 20; (59):1-66, A1-E7. PubMed ID: 11803702
    [Abstract] [Full Text] [Related]

  • 19. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.
    Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ.
    Carcinogenesis; 2007 Jan 20; 28(1):207-14. PubMed ID: 16885195
    [Abstract] [Full Text] [Related]

  • 20. Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
    Guengerich FP.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):369-78. PubMed ID: 15581593
    [Abstract] [Full Text] [Related]

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