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341 related items for PubMed ID: 21370851

  • 1. Characterization of a newly identified mycobacterial tautomerase with promiscuous dehalogenase and hydratase activities reveals a functional link to a recently diverged cis-3-chloroacrylic acid dehalogenase.
    Baas BJ, Zandvoort E, Wasiel AA, Quax WJ, Poelarends GJ.
    Biochemistry; 2011 Apr 12; 50(14):2889-99. PubMed ID: 21370851
    [Abstract] [Full Text] [Related]

  • 2. Characterization of Cg10062 from Corynebacterium glutamicum: implications for the evolution of cis-3-chloroacrylic acid dehalogenase activity in the tautomerase superfamily.
    Poelarends GJ, Serrano H, Person MD, Johnson WH, Whitman CP.
    Biochemistry; 2008 Aug 05; 47(31):8139-47. PubMed ID: 18598055
    [Abstract] [Full Text] [Related]

  • 3. Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases.
    Poelarends GJ, Serrano H, Person MD, Johnson WH, Murzin AG, Whitman CP.
    Biochemistry; 2004 Jan 27; 43(3):759-72. PubMed ID: 14730981
    [Abstract] [Full Text] [Related]

  • 4. Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction?
    Poelarends GJ, Johnson WH, Serrano H, Whitman CP.
    Biochemistry; 2007 Aug 21; 46(33):9596-604. PubMed ID: 17661448
    [Abstract] [Full Text] [Related]

  • 5. The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis.
    Azurmendi HF, Wang SC, Massiah MA, Poelarends GJ, Whitman CP, Mildvan AS.
    Biochemistry; 2004 Apr 13; 43(14):4082-91. PubMed ID: 15065850
    [Abstract] [Full Text] [Related]

  • 6. The hydratase activity of malonate semialdehyde decarboxylase: mechanistic and evolutionary implications.
    Poelarends GJ, Serrano H, Johnson WH, Hoffman DW, Whitman CP.
    J Am Chem Soc; 2004 Dec 08; 126(48):15658-9. PubMed ID: 15571384
    [Abstract] [Full Text] [Related]

  • 7. Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily.
    LeVieux JA, Baas BJ, Kaoud TS, Davidson R, Babbitt PC, Zhang YJ, Whitman CP.
    Arch Biochem Biophys; 2017 Dec 15; 636():50-56. PubMed ID: 29111295
    [Abstract] [Full Text] [Related]

  • 8. Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications.
    Poelarends GJ, Serrano H, Johnson WH, Whitman CP.
    Biochemistry; 2004 Jun 08; 43(22):7187-96. PubMed ID: 15170356
    [Abstract] [Full Text] [Related]

  • 9. Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: consequences of and evidence for a hydration reaction.
    Wang SC, Person MD, Johnson WH, Whitman CP.
    Biochemistry; 2003 Jul 29; 42(29):8762-73. PubMed ID: 12873137
    [Abstract] [Full Text] [Related]

  • 10. Reactions of 4-oxalocrotonate tautomerase and YwhB with 3-halopropiolates: analysis and implications.
    Wang SC, Johnson WH, Czerwinski RM, Whitman CP.
    Biochemistry; 2004 Jan 27; 43(3):748-58. PubMed ID: 14730980
    [Abstract] [Full Text] [Related]

  • 11. The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities.
    Wang SC, Johnson WH, Whitman CP.
    J Am Chem Soc; 2003 Nov 26; 125(47):14282-3. PubMed ID: 14624569
    [Abstract] [Full Text] [Related]

  • 12. Crystal structures of the wild-type, P1A mutant, and inactivated malonate semialdehyde decarboxylase: a structural basis for the decarboxylase and hydratase activities.
    Almrud JJ, Poelarends GJ, Johnson WH, Serrano H, Hackert ML, Whitman CP.
    Biochemistry; 2005 Nov 15; 44(45):14818-27. PubMed ID: 16274229
    [Abstract] [Full Text] [Related]

  • 13. The chemical versatility of the beta-alpha-beta fold: catalytic promiscuity and divergent evolution in the tautomerase superfamily.
    Poelarends GJ, Veetil VP, Whitman CP.
    Cell Mol Life Sci; 2008 Nov 15; 65(22):3606-18. PubMed ID: 18695941
    [Abstract] [Full Text] [Related]

  • 14. The 4-oxalocrotonate tautomerase family of enzymes: how nature makes new enzymes using a beta-alpha-beta structural motif.
    Whitman CP.
    Arch Biochem Biophys; 2002 Jun 01; 402(1):1-13. PubMed ID: 12051677
    [Abstract] [Full Text] [Related]

  • 15. Inactivation of malonate semialdehyde decarboxylase by 3-halopropiolates: evidence for hydratase activity.
    Poelarends GJ, Serrano H, Johnson WH, Whitman CP.
    Biochemistry; 2005 Jul 05; 44(26):9375-81. PubMed ID: 15982004
    [Abstract] [Full Text] [Related]

  • 16. Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate.
    de Jong RM, Bazzacco P, Poelarends GJ, Johnson WH, Kim YJ, Burks EA, Serrano H, Thunnissen AM, Whitman CP, Dijkstra BW.
    J Biol Chem; 2007 Jan 26; 282(4):2440-9. PubMed ID: 17121835
    [Abstract] [Full Text] [Related]

  • 17. A mutational analysis of the active site loop residues in cis-3-Chloroacrylic acid dehalogenase.
    Schroeder GK, Huddleston JP, Johnson WH, Whitman CP.
    Biochemistry; 2013 Jun 18; 52(24):4204-16. PubMed ID: 23692140
    [Abstract] [Full Text] [Related]

  • 18. Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase.
    Poelarends GJ, Almrud JJ, Serrano H, Darty JE, Johnson WH, Hackert ML, Whitman CP.
    Biochemistry; 2006 Jun 27; 45(25):7700-8. PubMed ID: 16784221
    [Abstract] [Full Text] [Related]

  • 19. Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural studies of the 1,3-dichloropropene catabolic enzymes.
    Poelarends GJ, Whitman CP.
    Bioorg Chem; 2004 Oct 27; 32(5):376-92. PubMed ID: 15381403
    [Abstract] [Full Text] [Related]

  • 20. Inactivation of Cg10062, a cis-3-chloroacrylic acid dehalogenase homologue in Corynebacterium glutamicum, by (R)- and (S)-oxirane-2-carboxylate: analysis and implications.
    Robertson BA, Johnson WH, Lo HH, Whitman CP.
    Biochemistry; 2008 Aug 19; 47(33):8796-803. PubMed ID: 18646866
    [Abstract] [Full Text] [Related]

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