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Journal Abstract Search
242 related items for PubMed ID: 21371603
1. Electron density guided fragment-based drug design--a lead generation example. Abad MC, Gibbs AC, Zhang X. Methods Enzymol; 2011; 493():487-508. PubMed ID: 21371603 [Abstract] [Full Text] [Related]
2. Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. Gibbs AC, Abad MC, Zhang X, Tounge BA, Lewandowski FA, Struble GT, Sun W, Sui Z, Kuo LC. J Med Chem; 2010 Nov 25; 53(22):7979-91. PubMed ID: 21033679 [Abstract] [Full Text] [Related]
6. Lead generation and examples opinion regarding how to follow up hits. Orita M, Ohno K, Warizaya M, Amano Y, Niimi T. Methods Enzymol; 2011 Nov 25; 493():383-419. PubMed ID: 21371599 [Abstract] [Full Text] [Related]
7. Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors. Wyss DF, Wang YS, Eaton HL, Strickland C, Voigt JH, Zhu Z, Stamford AW. Top Curr Chem; 2012 Nov 25; 317():83-114. PubMed ID: 21647837 [Abstract] [Full Text] [Related]
8. Fragment-based drug design. Feyfant E, Cross JB, Paris K, Tsao DH. Methods Mol Biol; 2011 Nov 25; 685():241-52. PubMed ID: 20981527 [Abstract] [Full Text] [Related]
11. In silico fragment screening by replica generation (FSRG) method for fragment-based drug design. Fukunishi Y, Mashimo T, Orita M, Ohno K, Nakamura H. J Chem Inf Model; 2009 Apr 25; 49(4):925-33. PubMed ID: 19354203 [Abstract] [Full Text] [Related]
16. Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology. Böttcher J, Jestel A, Kiefersauer R, Krapp S, Nagel S, Steinbacher S, Steuber H. Methods Enzymol; 2011 Apr 25; 493():61-89. PubMed ID: 21371587 [Abstract] [Full Text] [Related]
17. Two 'Golden Ratio' indices in fragment-based drug discovery. Orita M, Ohno K, Niimi T. Drug Discov Today; 2009 Mar 25; 14(5-6):321-8. PubMed ID: 19028598 [Abstract] [Full Text] [Related]
18. Fragment screening purely with protein crystallography. Spurlino JC. Methods Enzymol; 2011 Mar 25; 493():321-56. PubMed ID: 21371597 [Abstract] [Full Text] [Related]
19. From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance. Giannetti AM. Methods Enzymol; 2011 Mar 25; 493():169-218. PubMed ID: 21371592 [Abstract] [Full Text] [Related]