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PUBMED FOR HANDHELDS

Journal Abstract Search


242 related items for PubMed ID: 21371603

  • 1. Electron density guided fragment-based drug design--a lead generation example.
    Abad MC, Gibbs AC, Zhang X.
    Methods Enzymol; 2011; 493():487-508. PubMed ID: 21371603
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  • 2. Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.
    Gibbs AC, Abad MC, Zhang X, Tounge BA, Lewandowski FA, Struble GT, Sun W, Sui Z, Kuo LC.
    J Med Chem; 2010 Nov 25; 53(22):7979-91. PubMed ID: 21033679
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  • 6. Lead generation and examples opinion regarding how to follow up hits.
    Orita M, Ohno K, Warizaya M, Amano Y, Niimi T.
    Methods Enzymol; 2011 Nov 25; 493():383-419. PubMed ID: 21371599
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  • 7. Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
    Wyss DF, Wang YS, Eaton HL, Strickland C, Voigt JH, Zhu Z, Stamford AW.
    Top Curr Chem; 2012 Nov 25; 317():83-114. PubMed ID: 21647837
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  • 8. Fragment-based drug design.
    Feyfant E, Cross JB, Paris K, Tsao DH.
    Methods Mol Biol; 2011 Nov 25; 685():241-52. PubMed ID: 20981527
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  • 11. In silico fragment screening by replica generation (FSRG) method for fragment-based drug design.
    Fukunishi Y, Mashimo T, Orita M, Ohno K, Nakamura H.
    J Chem Inf Model; 2009 Apr 25; 49(4):925-33. PubMed ID: 19354203
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  • 16. Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology.
    Böttcher J, Jestel A, Kiefersauer R, Krapp S, Nagel S, Steinbacher S, Steuber H.
    Methods Enzymol; 2011 Apr 25; 493():61-89. PubMed ID: 21371587
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  • 17. Two 'Golden Ratio' indices in fragment-based drug discovery.
    Orita M, Ohno K, Niimi T.
    Drug Discov Today; 2009 Mar 25; 14(5-6):321-8. PubMed ID: 19028598
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  • 18. Fragment screening purely with protein crystallography.
    Spurlino JC.
    Methods Enzymol; 2011 Mar 25; 493():321-56. PubMed ID: 21371597
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  • 19. From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance.
    Giannetti AM.
    Methods Enzymol; 2011 Mar 25; 493():169-218. PubMed ID: 21371592
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