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Journal Abstract Search

135 related items for PubMed ID: 21377875

  • 1. Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators.
    Ushiroda K, Maruta K, Takazawa T, Nagano T, Taiji M, Kohno T, Sato Y, Horai S, Yanagi K, Nagata R.
    Bioorg Med Chem Lett; 2011 Apr 01; 21(7):1978-82. PubMed ID: 21377875
    [Abstract] [Full Text] [Related]

  • 2. Development of a new class of benzoylpyrrole-based PPARα/γ activators.
    Ushiroda K, Maruta K, Kitoh M, Iwai K, Nagamine J, Tsuchida A, Taiji M, Nagata R.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):220-4. PubMed ID: 21130649
    [Abstract] [Full Text] [Related]

  • 3. Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification.
    Zaware P, Shah SR, Pingali H, Makadia P, Thube B, Pola S, Patel D, Priyadarshini P, Suthar D, Shah M, Jamili J, Sairam KV, Giri S, Patel L, Patel H, Sudani H, Patel H, Jain M, Patel P, Bahekar R.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):628-32. PubMed ID: 21195611
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  • 5. Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
    Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N, Moore L, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Doweyko AM, Bell A, Chang C, Muckelbauer J, Zahler R, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1451-6. PubMed ID: 19201606
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  • 6. Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.
    Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM, Chandrasena G, Sleph P, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2312-6. PubMed ID: 17292606
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  • 8. 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.
    Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, Viaud-Massuard MC.
    Bioorg Med Chem Lett; 2008 Mar 01; 18(5):1617-22. PubMed ID: 18255290
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  • 10. [Design, synthesis, and PPARalpha/gamma agonistic activity of novel tetrahydroisoquinoline derivatives].
    Yu R, Zhou YL, Huan Y, Liu Q, Shen ZF, Liu ZZ.
    Yao Xue Xue Bao; 2011 Mar 01; 46(3):311-6. PubMed ID: 21626786
    [Abstract] [Full Text] [Related]

  • 11. Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
    Humphries PS, Bailey S, Almaden JV, Barnum SJ, Carlson TJ, Christie LC, Do QQ, Fraser JD, Hess M, Kellum J, Kim YH, McClellan GA, Ogilvie KM, Simmons BH, Skalitzky D, Sun S, Wilhite D, Zehnder LR.
    Bioorg Med Chem Lett; 2006 Dec 01; 16(23):6120-3. PubMed ID: 16973358
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  • 12. Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
    Liu K, Xu L, Berger JP, Macnaul KL, Zhou G, Doebber TW, Forrest MJ, Moller DE, Jones AB.
    J Med Chem; 2005 Apr 07; 48(7):2262-5. PubMed ID: 15801817
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, in vitro and in silico evaluation of l-tyrosine containing PPARalpha/gamma dual agonists.
    Kumar R, Ramachandran U, Khanna S, Bharatam PV, Raichur S, Chakrabarti R.
    Bioorg Med Chem; 2007 Feb 01; 15(3):1547-55. PubMed ID: 17166722
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  • 14. Dual PPAR-alpha and -gamma activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential.
    Madhavan GR, Chakrabarti R, Reddy KA, Rajesh BM, Balraju V, Rao PB, Rajagopalan R, Iqbal J.
    Bioorg Med Chem; 2006 Jan 15; 14(2):584-91. PubMed ID: 16198573
    [Abstract] [Full Text] [Related]

  • 15. Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
    Shi GQ, Dropinski JF, McKeever BM, Xu S, Becker JW, Berger JP, MacNaul KL, Elbrecht A, Zhou G, Doebber TW, Wang P, Chao YS, Forrest M, Heck JV, Moller DE, Jones AB.
    J Med Chem; 2005 Jun 30; 48(13):4457-68. PubMed ID: 15974597
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  • 16. Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.
    Oon Han H, Kim SH, Kim KH, Hur GC, Joo Yim H, Chung HK, Ho Woo S, Dong Koo K, Lee CS, Sung Koh J, Kim GT.
    Bioorg Med Chem Lett; 2007 Feb 15; 17(4):937-41. PubMed ID: 17157019
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  • 17. Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.
    Kim E, Park CS, Han T, Bae MH, Chong W, Lee CH, Shin YA, Ahn BN, Kim MK, Shin CY, Son MH, Kim JK, Moon HS, Shim HJ, Kim EJ, Kim SH, Lim JI, Lee CH.
    Bioorg Med Chem Lett; 2008 Sep 15; 18(18):4993-6. PubMed ID: 18771917
    [Abstract] [Full Text] [Related]

  • 18. PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.
    Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY.
    Eur J Pharmacol; 2008 Oct 24; 595(1-3):119-25. PubMed ID: 18727927
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.
    J Med Chem; 2008 Oct 23; 51(20):6318-33. PubMed ID: 18826205
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists.
    Lu Y, Guo Z, Guo Y, Feng J, Chu F.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):915-9. PubMed ID: 16300944
    [Abstract] [Full Text] [Related]

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