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Journal Abstract Search

135 related items for PubMed ID: 21377875

  • 21. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.
    Lin CH, Peng YH, Coumar MS, Chittimalla SK, Liao CC, Lyn PC, Huang CC, Lien TW, Lin WH, Hsu JT, Cheng JH, Chen X, Wu JS, Chao YS, Lee HJ, Juo CG, Wu SY, Hsieh HP.
    J Med Chem; 2009 Apr 23; 52(8):2618-22. PubMed ID: 19301897
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  • 23. Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents.
    Raval P, Jain M, Goswami A, Basu S, Gite A, Godha A, Pingali H, Raval S, Giri S, Suthar D, Shah M, Patel P.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3103-9. PubMed ID: 21450468
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  • 25. Synthesis and evaluation of azaindole-alpha-alkyloxyphenylpropionic acid analogues as PPARalpha/gamma agonists.
    Cai Z, Feng J, Guo Y, Li P, Shen Z, Chu F, Guo Z.
    Bioorg Med Chem; 2006 Feb 01; 14(3):866-74. PubMed ID: 16249089
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  • 27. Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives.
    Furukawa A, Arita T, Satoh S, Wakabayashi K, Hayashi S, Matsui Y, Araki K, Kuroha M, Ohsumi J.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2095-8. PubMed ID: 20219371
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  • 28. Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
    Ye XY, Li YX, Farrelly D, Flynn N, Gu L, Locke KT, Lippy J, O'Malley K, Twamley C, Zhang L, Ryono DE, Zahler R, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3545-50. PubMed ID: 18511276
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  • 29. Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.
    Casimiro-Garcia A, Bigge CF, Davis JA, Padalino T, Pulaski J, Ohren JF, McConnell P, Kane CD, Royer LJ, Stevens KA, Auerbach BJ, Collard WT, McGregor C, Fakhoury SA, Schaum RP, Zhou H.
    Bioorg Med Chem; 2008 May 01; 16(9):4883-907. PubMed ID: 18394907
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  • 30. Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.
    Fracchiolla G, Laghezza A, Piemontese L, Carbonara G, Lavecchia A, Tortorella P, Crestani M, Novellino E, Loiodice F.
    ChemMedChem; 2007 May 01; 2(5):641-54. PubMed ID: 17357171
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  • 32. Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
    Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Di Giovanni C, Carbonara G, Tortorella P, Novellino E, Loiodice F.
    Bioorg Med Chem; 2012 Mar 15; 20(6):2141-51. PubMed ID: 22341573
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  • 33. Differential antiatherogenic effects of PPARalpha versus PPARgamma agonists: should we be surprised?
    Camejo G.
    Arterioscler Thromb Vasc Biol; 2005 Sep 15; 25(9):1763-4. PubMed ID: 16127025
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  • 34. 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
    Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, Viaud-Massuard MC.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2683-7. PubMed ID: 19376700
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  • 35. Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.
    Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Märki HP, Meyer M, Mohr P.
    Bioorg Med Chem Lett; 2006 Aug 01; 16(15):4016-20. PubMed ID: 16737814
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  • 36. Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
    Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R, Cheng L, Sleph P, Sun W, Tieman A, Wetterau JR, Doweyko A, Chandrasena G, Chang SY, Humphreys WG, Sasseville VG, Biller SA, Ryono DE, Selan F, Hariharan N, Cheng PT.
    J Med Chem; 2005 Mar 24; 48(6):2248-50. PubMed ID: 15771468
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  • 37. Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.
    Liu W, Liu K, Wood HB, McCann ME, Doebber TW, Chang CH, Akiyama TE, Einstein M, Berger JP, Meinke PT.
    J Med Chem; 2009 Jul 23; 52(14):4443-53. PubMed ID: 19530681
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  • 40. Novel oxazole containing phenylpropane derivatives as peroxisome proliferator activated receptor agonists with hypolipidemic activity.
    Pingali H, Raval S, Raval P, Makadia P, Zaware P, Goel A, Suthar D, Jain M, Patel P.
    Pharmazie; 2008 Jul 23; 63(7):497-502. PubMed ID: 18717481
    [Abstract] [Full Text] [Related]

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