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881 related items for PubMed ID: 21389874

  • 1. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function.
    Hernandez-Chacon JA, Li Y, Wu RC, Bernatchez C, Wang Y, Weber JS, Hwu P, Radvanyi LG.
    J Immunother; 2011 Apr; 34(3):236-50. PubMed ID: 21389874
    [Abstract] [Full Text] [Related]

  • 2. Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.
    Chacon JA, Wu RC, Sukhumalchandra P, Molldrem JJ, Sarnaik A, Pilon-Thomas S, Weber J, Hwu P, Radvanyi L.
    PLoS One; 2013 Apr; 8(4):e60031. PubMed ID: 23560068
    [Abstract] [Full Text] [Related]

  • 3. TGF-beta1 induces preferential rapid expansion and persistence of tumor antigen-specific CD8+ T cells for adoptive immunotherapy.
    Liu S, Etto T, Rodríguez-Cruz T, Li Y, Wu C, Fulbright OJ, Hwu P, Radvanyi L, Lizée G.
    J Immunother; 2010 May; 33(4):371-81. PubMed ID: 20386469
    [Abstract] [Full Text] [Related]

  • 4. Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy.
    Chacon JA, Sarnaik AA, Chen JQ, Creasy C, Kale C, Robinson J, Weber J, Hwu P, Pilon-Thomas S, Radvanyi L.
    Clin Cancer Res; 2015 Feb 01; 21(3):611-21. PubMed ID: 25472998
    [Abstract] [Full Text] [Related]

  • 5. MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro.
    Li Y, Liu S, Hernandez J, Vence L, Hwu P, Radvanyi L.
    J Immunol; 2010 Jan 01; 184(1):452-65. PubMed ID: 19949105
    [Abstract] [Full Text] [Related]

  • 6. 4-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer.
    Sakellariou-Thompson D, Forget MA, Creasy C, Bernard V, Zhao L, Kim YU, Hurd MW, Uraoka N, Parra ER, Kang Y, Bristow CA, Rodriguez-Canales J, Fleming JB, Varadhachary G, Javle M, Overman MJ, Alvarez HA, Heffernan TP, Zhang J, Hwu P, Maitra A, Haymaker C, Bernatchez C.
    Clin Cancer Res; 2017 Dec 01; 23(23):7263-7275. PubMed ID: 28947567
    [Abstract] [Full Text] [Related]

  • 7. Specific antitumor activity of tumor-infiltrating lymphocytes expanded first in a culture with both anti-CD3 monoclonal antibody and activated B cells and then in a culture with interleukin-2.
    Tamada K, Harada M, Okamoto T, Takenoyama M, Ito O, Matsuzaki G, Nomoto K.
    Cancer Immunol Immunother; 1995 Dec 01; 41(6):339-47. PubMed ID: 8635191
    [Abstract] [Full Text] [Related]

  • 8. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy.
    Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, Watts TH.
    J Immunol; 2001 Aug 01; 167(3):1313-24. PubMed ID: 11466348
    [Abstract] [Full Text] [Related]

  • 9. 4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy.
    Zhang H, Snyder KM, Suhoski MM, Maus MV, Kapoor V, June CH, Mackall CL.
    J Immunol; 2007 Oct 01; 179(7):4910-8. PubMed ID: 17878391
    [Abstract] [Full Text] [Related]

  • 10. Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes.
    Shah P, Forget MA, Frank ML, Jiang P, Sakellariou-Thompson D, Federico L, Khairullah R, Neutzler CA, Wistuba I, Chow CB, Long Y, Fujimoto J, Lin SY, Maitra A, Negrao MV, Mitchell KG, Weissferdt A, Vaporciyan AA, Cascone T, Roth JA, Zhang J, Sepesi B, Gibbons DL, Heymach JV, Haymaker CL, McGrail DJ, Reuben A, Bernatchez C.
    J Immunother Cancer; 2022 Feb 01; 10(2):. PubMed ID: 35110355
    [Abstract] [Full Text] [Related]

  • 11. Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy.
    Huang J, Kerstann KW, Ahmadzadeh M, Li YF, El-Gamil M, Rosenberg SA, Robbins PF.
    J Immunol; 2006 Jun 15; 176(12):7726-35. PubMed ID: 16751420
    [Abstract] [Full Text] [Related]

  • 12. During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.
    Hendriks J, Xiao Y, Rossen JW, van der Sluijs KF, Sugamura K, Ishii N, Borst J.
    J Immunol; 2005 Aug 01; 175(3):1665-76. PubMed ID: 16034107
    [Abstract] [Full Text] [Related]

  • 13. Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumour-infiltrating lymphocytes.
    Ju SA, Lee SC, Kwon TH, Heo SK, Park SM, Paek HN, Suh JH, Cho HR, Kwon B, Kwon BS, Kim BS.
    Immunol Cell Biol; 2005 Aug 01; 83(4):344-51. PubMed ID: 16033529
    [Abstract] [Full Text] [Related]

  • 14. Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling.
    Hombach AA, Abken H.
    Int J Cancer; 2011 Dec 15; 129(12):2935-44. PubMed ID: 22030616
    [Abstract] [Full Text] [Related]

  • 15. CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent.
    Lee SJ, Rossi RJ, Lee SK, Croft M, Kwon BS, Mittler RS, Vella AT.
    J Immunol; 2007 Aug 15; 179(4):2203-14. PubMed ID: 17675480
    [Abstract] [Full Text] [Related]

  • 16. 4-1BB Delineates Distinct Activation Status of Exhausted Tumor-Infiltrating CD8+ T Cells in Hepatocellular Carcinoma.
    Kim HD, Park S, Jeong S, Lee YJ, Lee H, Kim CG, Kim KH, Hong SM, Lee JY, Kim S, Kim HK, Min BS, Chang JH, Ju YS, Shin EC, Song GW, Hwang S, Park SH.
    Hepatology; 2020 Mar 15; 71(3):955-971. PubMed ID: 31353502
    [Abstract] [Full Text] [Related]

  • 17. IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.
    Santegoets SJ, Turksma AW, Suhoski MM, Stam AG, Albelda SM, Hooijberg E, Scheper RJ, van den Eertwegh AJ, Gerritsen WR, Powell DJ, June CH, de Gruijl TD.
    J Transl Med; 2013 Feb 12; 11():37. PubMed ID: 23402380
    [Abstract] [Full Text] [Related]

  • 18. A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors.
    Konstorum A, Vella AT, Adler AJ, Laubenbacher RC.
    Sci Rep; 2019 Jul 26; 9(1):10862. PubMed ID: 31350431
    [Abstract] [Full Text] [Related]

  • 19. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function.
    Wen T, Bukczynski J, Watts TH.
    J Immunol; 2002 May 15; 168(10):4897-906. PubMed ID: 11994439
    [Abstract] [Full Text] [Related]

  • 20. Modulation of cord blood CD8+ T-cell effector differentiation by TGF-beta1 and 4-1BB costimulation.
    Kim YJ, Stringfield TM, Chen Y, Broxmeyer HE.
    Blood; 2005 Jan 01; 105(1):274-81. PubMed ID: 15353478
    [Abstract] [Full Text] [Related]

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