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225 related items for PubMed ID: 21391227

  • 1. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
    Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS.
    Hepatology; 2011 Jun; 53(6):1943-58. PubMed ID: 21391227
    [Abstract] [Full Text] [Related]

  • 2. ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo.
    Mani R, Chiang CL, Frissora FW, Yan R, Mo X, Baskar S, Rader C, Klisovic R, Phelps MA, Chen CS, Lee RJ, Byrd JC, Baiocchi R, Lee LJ, Muthusamy N.
    Exp Hematol; 2015 Sep; 43(9):770-4.e2. PubMed ID: 25937048
    [Abstract] [Full Text] [Related]

  • 3. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
    Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS.
    Cancer Res; 2008 Feb 15; 68(4):1204-12. PubMed ID: 18281497
    [Abstract] [Full Text] [Related]

  • 4. Non-immunosuppressive FTY720-derivative OSU-2S mediates reactive oxygen species-mediated cytotoxicity in canine B-cell lymphoma.
    Mani R, Yan R, Mo X, Chen CS, Phelps MA, Klisovic R, Byrd JC, Kisseberth WC, London CA, Muthusamy N.
    Vet Comp Oncol; 2017 Sep 15; 15(3):1115-1118. PubMed ID: 27136276
    [Abstract] [Full Text] [Related]

  • 5. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
    Nagaoka Y, Otsuki K, Fujita T, Uesato S.
    Biol Pharm Bull; 2008 Jun 15; 31(6):1177-81. PubMed ID: 18520051
    [Abstract] [Full Text] [Related]

  • 6. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.
    Zhang L, Wang H, Ding K, Xu J.
    Toxicol Lett; 2015 Jul 02; 236(1):43-59. PubMed ID: 25939952
    [Abstract] [Full Text] [Related]

  • 7. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.
    Yoshino T, Tabunoki H, Sugiyama S, Ishii K, Kim SU, Satoh J.
    Cell Mol Neurobiol; 2011 Oct 02; 31(7):1009-20. PubMed ID: 21519925
    [Abstract] [Full Text] [Related]

  • 8. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
    Lee TK, Man K, Ho JW, Sun CK, Ng KT, Wang XH, Wong YC, Ng IO, Xu R, Fan ST.
    Carcinogenesis; 2004 Dec 02; 25(12):2397-405. PubMed ID: 15297371
    [Abstract] [Full Text] [Related]

  • 9. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia.
    Mani R, Mao Y, Frissora FW, Chiang CL, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X, Yu L, Flynn J, Jones J, Andritsos L, Baskar S, Rader C, Phelps MA, Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N.
    Leukemia; 2015 Feb 02; 29(2):346-55. PubMed ID: 24947019
    [Abstract] [Full Text] [Related]

  • 10. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.
    Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Caraglia M, Tassone P, Tagliaferri P.
    Cancer Biol Ther; 2014 Jun 01; 15(6):797-805. PubMed ID: 24657936
    [Abstract] [Full Text] [Related]

  • 11. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling.
    Lu Z, Wang J, Zheng T, Liang Y, Yin D, Song R, Pei T, Pan S, Jiang H, Liu L.
    BMC Cancer; 2014 Oct 25; 14():783. PubMed ID: 25344679
    [Abstract] [Full Text] [Related]

  • 12. Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.
    Estrada-Bernal A, Palanichamy K, Ray Chaudhury A, Van Brocklyn JR.
    Neuro Oncol; 2012 Apr 25; 14(4):405-15. PubMed ID: 22351749
    [Abstract] [Full Text] [Related]

  • 13. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway.
    Li MH, Hla T, Ferrer F.
    Pediatr Blood Cancer; 2013 Sep 25; 60(9):1418-23. PubMed ID: 23704073
    [Abstract] [Full Text] [Related]

  • 14. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
    Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissié J, Malavaud B, Waxman J, Cuvillier O.
    Cancer Res; 2010 Nov 01; 70(21):8651-61. PubMed ID: 20959468
    [Abstract] [Full Text] [Related]

  • 15. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.
    Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J.
    Proc Natl Acad Sci U S A; 2011 Jan 11; 108(2):751-6. PubMed ID: 21177428
    [Abstract] [Full Text] [Related]

  • 16. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
    Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T.
    J Biol Chem; 2007 Mar 23; 282(12):9082-9. PubMed ID: 17237497
    [Abstract] [Full Text] [Related]

  • 17. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53.
    Omar HA, Tolba MF, Hung JH, Al-Tel TH.
    Front Pharmacol; 2016 Mar 23; 7():463. PubMed ID: 27965580
    [Abstract] [Full Text] [Related]

  • 18. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
    Brinkmann V.
    Br J Pharmacol; 2009 Nov 23; 158(5):1173-82. PubMed ID: 19814729
    [Abstract] [Full Text] [Related]

  • 19. Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma.
    Omar HA, Sargeant AM, Weng JR, Wang D, Kulp SK, Patel T, Chen CS.
    Mol Pharmacol; 2009 Nov 23; 76(5):957-68. PubMed ID: 19706731
    [Abstract] [Full Text] [Related]

  • 20. Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog.
    Ushitora Y, Tashiro H, Ogawa T, Tanimoto Y, Kuroda S, Kobayashi T, Miyata Y, Itamoto T, Asahara T, Ohdan H.
    Transplantation; 2009 Oct 27; 88(8):980-6. PubMed ID: 19855243
    [Abstract] [Full Text] [Related]

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