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Journal Abstract Search

133 related items for PubMed ID: 21398123

  • 1. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
    Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2468-71. PubMed ID: 21398123
    [Abstract] [Full Text] [Related]

  • 2. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
    Grädler U, Fuchss T, Ulrich WR, Boer R, Strub A, Hesslinger C, Anézo C, Diederichs K, Zaliani A.
    Bioorg Med Chem Lett; 2011 Jul 15; 21(14):4228-32. PubMed ID: 21684157
    [Abstract] [Full Text] [Related]

  • 3. Discovery of a series of aminopiperidines as novel iNOS inhibitors.
    Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):336-43. PubMed ID: 18024030
    [Abstract] [Full Text] [Related]

  • 4. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.
    Strub A, Ulrich WR, Hesslinger C, Eltze M, Fuchss T, Strassner J, Strand S, Lehner MD, Boer R.
    Mol Pharmacol; 2006 Jan 01; 69(1):328-37. PubMed ID: 16223957
    [Abstract] [Full Text] [Related]

  • 5. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2009 May 14; 52(9):3047-62. PubMed ID: 19374401
    [Abstract] [Full Text] [Related]

  • 6. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC, Camacho ME, Carrión MD, Tapias V, Gallo MA, Escames G, Acuña-Castroviejo D, Espinosa A, Entrena A.
    Eur J Med Chem; 2009 Jun 14; 44(6):2655-66. PubMed ID: 19117642
    [Abstract] [Full Text] [Related]

  • 7. Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
    Payne JE, Bonnefous C, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2010 Nov 11; 53(21):7739-55. PubMed ID: 20931971
    [Abstract] [Full Text] [Related]

  • 8. The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase.
    Whitlow M, Adler M, Davey D, Huang Q, Koovakkat S, Parkinson JF, Pham E, Polokoff M, Xu W, Yuan S, Phillips G.
    Bioorg Med Chem Lett; 2007 May 01; 17(9):2505-8. PubMed ID: 17336523
    [Abstract] [Full Text] [Related]

  • 9. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
    Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ.
    Mol Pharmacol; 2008 Apr 01; 73(4):1244-53. PubMed ID: 18178668
    [Abstract] [Full Text] [Related]

  • 10. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).
    Carrión MD, López Cara LC, Camacho ME, Tapias V, Escames G, Acuña-Castroviejo D, Espinosa A, Gallo MA, Entrena A.
    Eur J Med Chem; 2008 Nov 01; 43(11):2579-91. PubMed ID: 18325637
    [Abstract] [Full Text] [Related]

  • 11. Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
    Durón SG, Lindstrom A, Bonnefous C, Zhang H, Chen X, Symons KT, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1237-41. PubMed ID: 22182498
    [Abstract] [Full Text] [Related]

  • 12. In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.
    Lehner MD, Marx D, Boer R, Strub A, Hesslinger C, Eltze M, Ulrich WR, Schwoebel F, Schermuly RT, Barsig J.
    J Pharmacol Exp Ther; 2006 Apr 15; 317(1):181-7. PubMed ID: 16368897
    [Abstract] [Full Text] [Related]

  • 13. Selective inhibition of iNOS by benzyl- and dibenzyl derivatives of N-(3-aminobenzyl)acetamidine.
    Fantacuzzi M, Maccallini C, Lannutti F, Patruno A, Masella S, Pesce M, Speranza L, Ammazzalorso A, De Filippis B, Giampietro L, Re N, Amoroso R.
    ChemMedChem; 2011 Jul 04; 6(7):1203-6. PubMed ID: 21567968
    [No Abstract] [Full Text] [Related]

  • 14. Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
    Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.
    Bioorg Med Chem Lett; 2011 Nov 15; 21(22):6888-94. PubMed ID: 21986586
    [Abstract] [Full Text] [Related]

  • 15. Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
    Young RJ, Alderton W, Angell AD, Beswick PJ, Brown D, Chambers CL, Crowe MC, Dawson J, Hamlett CC, Hodgson ST, Kleanthous S, Knowles RG, Russell LJ, Stocker R, Woolven JM.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3037-40. PubMed ID: 21482467
    [Abstract] [Full Text] [Related]

  • 16. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
    Hah JM, Martásek P, Roman LJ, Silverman RB.
    J Med Chem; 2003 Apr 24; 46(9):1661-9. PubMed ID: 12699384
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase.
    Jackson SA, Sahni S, Lee L, Luo Y, Nieduzak TR, Liang G, Chiang Y, Collar N, Fink D, He W, Laoui A, Merrill J, Boffey R, Crackett P, Rees B, Wong M, Guilloteau JP, Mathieu M, Rebello SS.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2723-39. PubMed ID: 15781384
    [Abstract] [Full Text] [Related]

  • 18. 1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
    Wei RG, Adler M, Davey D, Ho E, Mohan R, Polokoff M, Tseng JL, Whitlow M, Xu W, Yuan S, Phillips G.
    Bioorg Med Chem Lett; 2007 May 01; 17(9):2499-504. PubMed ID: 17368901
    [Abstract] [Full Text] [Related]

  • 19. Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.
    Shi JB, Chen LZ, Wang BS, Huang X, Jiao MM, Liu MM, Tang WJ, Liu XH.
    J Med Chem; 2019 Apr 25; 62(8):4013-4031. PubMed ID: 30925056
    [Abstract] [Full Text] [Related]

  • 20. Identification of iNOS inhibitors using InteraX.
    Mallinder PR, Wallace AV, Allenby G.
    J Biomol Screen; 2009 Mar 25; 14(3):263-72. PubMed ID: 19211775
    [Abstract] [Full Text] [Related]

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