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Journal Abstract Search

424 related items for PubMed ID: 21403840

  • 1.
    ; . PubMed ID:
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  • 2. Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
    Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ.
    Clin Cancer Res; 2014 Mar 01; 20(5):1190-203. PubMed ID: 24277455
    [Abstract] [Full Text] [Related]

  • 3. Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.
    Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ.
    J Natl Cancer Inst; 2011 Jun 22; 103(12):962-78. PubMed ID: 21653923
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  • 4. Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma.
    Tosso PN, Kong Y, Scher L, Cummins R, Schneider J, Rahim S, Holman KT, Toretsky J, Wang K, Üren A, Brown ML.
    J Med Chem; 2014 Dec 26; 57(24):10290-303. PubMed ID: 25432018
    [Abstract] [Full Text] [Related]

  • 5. BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.
    Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J.
    Oncotarget; 2016 Jul 12; 7(28):43504-43517. PubMed ID: 27259270
    [Abstract] [Full Text] [Related]

  • 6. Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.
    Harlow ML, Chasse MH, Boguslawski EA, Sorensen KM, Gedminas JM, Kitchen-Goosen SM, Rothbart SB, Taslim C, Lessnick SL, Peck AS, Madaj ZB, Bowman MJ, Grohar PJ.
    Clin Cancer Res; 2019 Jun 01; 25(11):3417-3429. PubMed ID: 30723142
    [Abstract] [Full Text] [Related]

  • 7. Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.
    Jacques C, Lamoureux F, Baud'huin M, Rodriguez Calleja L, Quillard T, Amiaud J, Tirode F, Rédini F, Bradner JE, Heymann D, Ory B.
    Oncotarget; 2016 Apr 26; 7(17):24125-40. PubMed ID: 27006472
    [Abstract] [Full Text] [Related]

  • 8. Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.
    Osgood CL, Maloney N, Kidd CG, Kitchen-Goosen S, Segars L, Gebregiorgis M, Woldemichael GM, He M, Sankar S, Lessnick SL, Kang M, Smith M, Turner L, Madaj ZB, Winn ME, Núñez LE, González-Sabín J, Helman LJ, Morís F, Grohar PJ.
    Clin Cancer Res; 2016 Aug 15; 22(16):4105-18. PubMed ID: 26979396
    [Abstract] [Full Text] [Related]

  • 9. Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.
    Theisen ER, Pishas KI, Saund RS, Lessnick SL.
    Oncotarget; 2016 Apr 05; 7(14):17616-30. PubMed ID: 26848860
    [Abstract] [Full Text] [Related]

  • 10. PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.
    Giorgi C, Boro A, Rechfeld F, Lopez-Garcia LA, Gierisch ME, Schäfer BW, Niggli FK.
    Oncotarget; 2015 Oct 06; 6(30):28895-910. PubMed ID: 26336820
    [Abstract] [Full Text] [Related]

  • 11. Pharmaceutical Interference of the EWS-FLI1-driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma.
    Heisey DAR, Jacob S, Lochmann TL, Kurupi R, Ghotra MS, Calbert ML, Shende M, Maves YK, Koblinski JE, Dozmorov MG, Boikos SA, Benes CH, Faber AC.
    Mol Cancer Ther; 2021 Oct 06; 20(10):1868-1879. PubMed ID: 34315769
    [Abstract] [Full Text] [Related]

  • 12. Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.
    Stoll G, Surdez D, Tirode F, Laud K, Barillot E, Zinovyev A, Delattre O.
    Nucleic Acids Res; 2013 Oct 06; 41(19):8853-71. PubMed ID: 23935076
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma.
    Zöllner SK, Selvanathan SP, Graham GT, Commins RMT, Hong SH, Moseley E, Parks S, Haladyna JN, Erkizan HV, Dirksen U, Hogarty MD, Üren A, Toretsky JA.
    Sci Signal; 2017 Oct 03; 10(499):. PubMed ID: 28974650
    [Abstract] [Full Text] [Related]

  • 14. Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.
    Niedan S, Kauer M, Aryee DN, Kofler R, Schwentner R, Meier A, Pötschger U, Kontny U, Kovar H.
    Oncogene; 2014 Jul 24; 33(30):3927-38. PubMed ID: 23995784
    [Abstract] [Full Text] [Related]

  • 15. SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma.
    Tang SW, Bilke S, Cao L, Murai J, Sousa FG, Yamade M, Rajapakse V, Varma S, Helman LJ, Khan J, Meltzer PS, Pommier Y.
    Clin Cancer Res; 2015 Sep 15; 21(18):4184-93. PubMed ID: 25779942
    [Abstract] [Full Text] [Related]

  • 16. Targeting the EWS-FLI1 transcription factor in Ewing sarcoma.
    Tancredi R, Zambelli A, DaPrada GA, Fregoni V, Pavesi L, Riccardi A, Burdach S, Grohar PJ, D'Incalci M.
    Cancer Chemother Pharmacol; 2015 Jun 15; 75(6):1317-20. PubMed ID: 25809543
    [Abstract] [Full Text] [Related]

  • 17. Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.
    Grohar PJ, Kim S, Rangel Rivera GO, Sen N, Haddock S, Harlow ML, Maloney NK, Zhu J, O'Neill M, Jones TL, Huppi K, Grandin M, Gehlhaus K, Klumpp-Thomas CA, Buehler E, Helman LJ, Martin SE, Caplen NJ.
    Cell Rep; 2016 Jan 26; 14(3):598-610. PubMed ID: 26776507
    [Abstract] [Full Text] [Related]

  • 18. EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
    Jiménez JA, Apfelbaum AA, Hawkins AG, Svoboda LK, Kumar A, Ruiz RO, Garcia AX, Haarer E, Nwosu ZC, Bradin J, Purohit T, Chen D, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER.
    Mol Cancer Res; 2021 Jul 26; 19(7):1182-1195. PubMed ID: 33741715
    [Abstract] [Full Text] [Related]

  • 19. Pharmacokinetic modeling optimizes inhibition of the 'undruggable' EWS-FLI1 transcription factor in Ewing Sarcoma.
    Hong SH, Youbi SE, Hong SP, Kallakury B, Monroe P, Erkizan HV, Barber-Rotenberg JS, Houghton P, Üren A, Toretsky JA.
    Oncotarget; 2014 Jan 30; 5(2):338-50. PubMed ID: 24481407
    [Abstract] [Full Text] [Related]

  • 20. The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.
    Mendiola M, Carrillo J, García E, Lalli E, Hernández T, de Alava E, Tirode F, Delattre O, García-Miguel P, López-Barea F, Pestaña A, Alonso J.
    Int J Cancer; 2006 Mar 15; 118(6):1381-9. PubMed ID: 16206264
    [Abstract] [Full Text] [Related]

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