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496 related items for PubMed ID: 21425328

  • 1. Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.
    Chiu YJ, Hour MJ, Lu CC, Chung JG, Kuo SC, Huang WW, Chen HJ, Jin YA, Yang JS.
    J Orthop Res; 2011 Sep; 29(9):1448-56. PubMed ID: 21425328
    [Abstract] [Full Text] [Related]

  • 2. Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells.
    Lai JM, Chang JT, Wen CL, Hsu SL.
    Eur J Pharmacol; 2009 Nov 25; 623(1-3):1-9. PubMed ID: 19744477
    [Abstract] [Full Text] [Related]

  • 3. The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
    Chen HY, Lu HF, Yang JS, Kuo SC, Lo C, Yang MD, Chiu TH, Chueh FS, Ho HC, Ko YC, Chung JG.
    Anticancer Res; 2010 Oct 25; 30(10):4187-92. PubMed ID: 21036739
    [Abstract] [Full Text] [Related]

  • 4. Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity.
    Yoshida M, Shiojima I, Ikeda H, Komuro I.
    J Mol Cell Cardiol; 2009 Nov 25; 47(5):698-705. PubMed ID: 19660469
    [Abstract] [Full Text] [Related]

  • 5. Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells.
    Wu CL, Huang AC, Yang JS, Liao CL, Lu HF, Chou ST, Ma CY, Hsia TC, Ko YC, Chung JG.
    J Orthop Res; 2011 Aug 25; 29(8):1199-209. PubMed ID: 21374707
    [Abstract] [Full Text] [Related]

  • 6. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells.
    Huang WW, Chiu YJ, Fan MJ, Lu HF, Yeh HF, Li KH, Chen PY, Chung JG, Yang JS.
    Mol Nutr Food Res; 2010 Nov 25; 54(11):1585-95. PubMed ID: 20564475
    [Abstract] [Full Text] [Related]

  • 7. Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.
    Yang JS, Hour MJ, Kuo SC, Huang LJ, Lee MR.
    Anticancer Res; 2004 Nov 25; 24(3a):1769-78. PubMed ID: 15274354
    [Abstract] [Full Text] [Related]

  • 8. Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway.
    Chuang CY, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL.
    J Agric Food Chem; 2010 Mar 10; 58(5):2943-51. PubMed ID: 20151649
    [Abstract] [Full Text] [Related]

  • 9. Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells.
    Chang YH, Yang JS, Kuo SC, Chung JG.
    Anticancer Res; 2009 Aug 10; 29(8):3139-48. PubMed ID: 19661327
    [Abstract] [Full Text] [Related]

  • 10. ATM/ATR and SMAD3 pathways contribute to 3-indole-induced G₁ arrest in cancer cells and xenograft models.
    Huang SM, Lu KT, Wang YC.
    Anticancer Res; 2011 Jan 10; 31(1):203-8. PubMed ID: 21273599
    [Abstract] [Full Text] [Related]

  • 11. Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53.
    Wang J, Pabla N, Wang CY, Wang W, Schoenlein PV, Dong Z.
    Am J Physiol Renal Physiol; 2006 Dec 10; 291(6):F1300-7. PubMed ID: 16849690
    [Abstract] [Full Text] [Related]

  • 12. Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated.
    Jang SH, Lim JW, Kim H.
    Ann N Y Acad Sci; 2009 Aug 10; 1171():156-62. PubMed ID: 19723050
    [Abstract] [Full Text] [Related]

  • 13. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
    Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R.
    Int J Oncol; 2004 Mar 10; 24(3):591-608. PubMed ID: 14767544
    [Abstract] [Full Text] [Related]

  • 14. Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways.
    Shyur LF, Lee SH, Chang ST, Lo CP, Kuo YH, Wang SY.
    Phytomedicine; 2010 Dec 15; 18(1):16-24. PubMed ID: 20637573
    [Abstract] [Full Text] [Related]

  • 15. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
    Wang SC, Wu CC, Wei YY, Hong JH, Chiang CS.
    Int J Radiat Biol; 2011 Apr 15; 87(4):432-42. PubMed ID: 21204616
    [Abstract] [Full Text] [Related]

  • 16. Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
    Yim H, Hwang IS, Choi JS, Chun KH, Jin YH, Ham YM, Lee KY, Lee SK.
    J Cell Biol; 2006 Jul 03; 174(1):77-88. PubMed ID: 16801388
    [Abstract] [Full Text] [Related]

  • 17. Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line.
    Hsu SC, Yang JS, Kuo CL, Lo C, Lin JP, Hsia TC, Lin JJ, Lai KC, Kuo HM, Huang LJ, Kuo SC, Wood WG, Chung JG.
    J Orthop Res; 2009 Dec 03; 27(12):1637-44. PubMed ID: 19557855
    [Abstract] [Full Text] [Related]

  • 18. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.
    Eur J Pharmacol; 2007 Jun 01; 563(1-3):49-60. PubMed ID: 17341418
    [Abstract] [Full Text] [Related]

  • 19. Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
    Erker L, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A.
    Hum Mol Genet; 2005 Jun 15; 14(12):1699-708. PubMed ID: 15888486
    [Abstract] [Full Text] [Related]

  • 20. The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.
    Chen KT, Hour MJ, Tsai SC, Chung JG, Kuo SC, Lu CC, Chiu YJ, Chuang YH, Yang JS.
    Int J Oncol; 2011 Sep 15; 39(3):611-9. PubMed ID: 21667022
    [Abstract] [Full Text] [Related]

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