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Journal Abstract Search

344 related items for PubMed ID: 21427202

  • 1. Glucuronidation of anticancer prodrug PR-104A: species differences, identification of human UDP-glucuronosyltransferases, and implications for therapy.
    Gu Y, Tingle MD, Wilson WR.
    J Pharmacol Exp Ther; 2011 Jun; 337(3):692-702. PubMed ID: 21427202
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  • 3. Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs, and humans.
    Gu Y, Atwell GJ, Wilson WR.
    Drug Metab Dispos; 2010 Mar; 38(3):498-508. PubMed ID: 20019245
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  • 4. The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.
    Guise CP, Abbattista MR, Singleton RS, Holford SD, Connolly J, Dachs GU, Fox SB, Pollock R, Harvey J, Guilford P, Doñate F, Wilson WR, Patterson AV.
    Cancer Res; 2010 Feb 15; 70(4):1573-84. PubMed ID: 20145130
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  • 5. Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.
    Wen Z, Martin DE, Bullock P, Lee KH, Smith PC.
    Drug Metab Dispos; 2007 Mar 15; 35(3):440-8. PubMed ID: 17151190
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  • 6. Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: a role for NADPH:cytochrome P450 oxidoreductase under hypoxia.
    Guise CP, Wang AT, Theil A, Bridewell DJ, Wilson WR, Patterson AV.
    Biochem Pharmacol; 2007 Sep 15; 74(6):810-20. PubMed ID: 17645874
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  • 7. Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.
    Innocenti F, Iyer L, Ramírez J, Green MD, Ratain MJ.
    Drug Metab Dispos; 2001 May 15; 29(5):686-92. PubMed ID: 11302935
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  • 12. Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.
    Abbattista MR, Jamieson SM, Gu Y, Nickel JE, Pullen SM, Patterson AV, Wilson WR, Guise CP.
    Cancer Biol Ther; 2015 May 15; 16(4):610-22. PubMed ID: 25869917
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  • 15. Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.
    Wang Q, Hao H, Zhu X, Yu G, Lai L, Liu Y, Wang Y, Jiang S, Wang G.
    Drug Metab Dispos; 2010 Jul 15; 38(7):1132-40. PubMed ID: 20382756
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  • 16. Sequential metabolism of sesamin by cytochrome P450 and UDP-glucuronosyltransferase in human liver.
    Yasuda K, Ikushiro S, Kamakura M, Munetsuna E, Ohta M, Sakaki T.
    Drug Metab Dispos; 2011 Sep 15; 39(9):1538-45. PubMed ID: 21622626
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  • 17. Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation.
    Hanioka N, Naito T, Narimatsu S.
    Chemosphere; 2008 Dec 15; 74(1):33-6. PubMed ID: 18990428
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  • 18. A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.
    Patel K, Choy SS, Hicks KO, Melink TJ, Holford NH, Wilson WR.
    Cancer Chemother Pharmacol; 2011 May 15; 67(5):1145-55. PubMed ID: 20683596
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