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Journal Abstract Search

305 related items for PubMed ID: 21439245

  • 1. MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.
    Wu M, Shu HB.
    Chin J Cancer; 2011 Apr; 30(4):240-6. PubMed ID: 21439245
    [Abstract] [Full Text] [Related]

  • 2. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A, Dharmarajan V, Vought VE, Cosgrove MS.
    J Biol Chem; 2009 Sep 04; 284(36):24242-56. PubMed ID: 19556245
    [Abstract] [Full Text] [Related]

  • 3. Regulation of MLL1 H3K4 methyltransferase activity by its core components.
    Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG.
    Nat Struct Mol Biol; 2006 Aug 04; 13(8):713-9. PubMed ID: 16878130
    [Abstract] [Full Text] [Related]

  • 4. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V, Lee JH, Patel A, Skalnik DG, Cosgrove MS.
    J Biol Chem; 2012 Aug 10; 287(33):27275-89. PubMed ID: 22665483
    [Abstract] [Full Text] [Related]

  • 5. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL, Shinsky SA, Loh DM, Lee JH, Skalnik DG, Cosgrove MS.
    J Biol Chem; 2016 Oct 21; 291(43):22357-22372. PubMed ID: 27563068
    [Abstract] [Full Text] [Related]

  • 6. WDR5, a complexed protein.
    Trievel RC, Shilatifard A.
    Nat Struct Mol Biol; 2009 Jul 21; 16(7):678-80. PubMed ID: 19578375
    [No Abstract] [Full Text] [Related]

  • 7. Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
    Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS.
    J Biol Chem; 2014 Jan 10; 289(2):868-84. PubMed ID: 24235145
    [Abstract] [Full Text] [Related]

  • 8. Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.
    Weirich S, Kudithipudi S, Jeltsch A.
    Mol Oncol; 2017 Apr 10; 11(4):373-387. PubMed ID: 28182322
    [Abstract] [Full Text] [Related]

  • 9. The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein- Protein Interaction.
    Ye X, Chen G, Jin J, Zhang B, Wang Y, Cai Z, Ye F.
    Curr Med Chem; 2020 Apr 10; 27(33):5530-5542. PubMed ID: 31132972
    [Abstract] [Full Text] [Related]

  • 10. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.
    Kim JY, Banerjee T, Vinckevicius A, Luo Q, Parker JB, Baker MR, Radhakrishnan I, Wei JJ, Barish GD, Chakravarti D.
    Mol Cell; 2014 May 22; 54(4):613-25. PubMed ID: 24793694
    [Abstract] [Full Text] [Related]

  • 11. Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
    Chen WL, Li DD, Chen X, Wang YZ, Xu JJ, Jiang ZY, You QD, Guo XK.
    Eur J Med Chem; 2020 Feb 15; 188():112027. PubMed ID: 31923859
    [Abstract] [Full Text] [Related]

  • 12. PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells.
    Liu C, Zhang Y, Hou Y, Shen L, Li Y, Guo W, Xu D, Liu G, Zhao Z, Man K, Pan Y, Wang Z, Chen Y.
    Biochem J; 2015 May 01; 467(3):415-24. PubMed ID: 25706881
    [Abstract] [Full Text] [Related]

  • 13. A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A, Vought VE, Dharmarajan V, Cosgrove MS.
    J Biol Chem; 2011 Feb 04; 286(5):3359-69. PubMed ID: 21106533
    [Abstract] [Full Text] [Related]

  • 14. PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes.
    Wang Q, Yu M, Ma Y, Zhang X, Zhang H, Li S, Lan R, Lu F.
    Lab Invest; 2018 Dec 04; 98(12):1627-1641. PubMed ID: 30089852
    [Abstract] [Full Text] [Related]

  • 15. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
    Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S.
    J Am Chem Soc; 2013 Jan 16; 135(2):669-82. PubMed ID: 23210835
    [Abstract] [Full Text] [Related]

  • 16. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
    Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S, Liu L, Chen Y, Ouillette P, Zhu J, Hess JL, Atadja P, Lei M, Qin ZS, Malek S, Wang S, Dou Y.
    Mol Cell; 2014 Jan 23; 53(2):247-61. PubMed ID: 24389101
    [Abstract] [Full Text] [Related]

  • 17. The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
    Kaustov L, Lemak A, Wu H, Faini M, Fan L, Fang X, Zeng H, Duan S, Allali-Hassani A, Li F, Wei Y, Vedadi M, Aebersold R, Wang Y, Houliston S, Arrowsmith CH.
    Nucleic Acids Res; 2019 Sep 26; 47(17):9433-9447. PubMed ID: 31400120
    [Abstract] [Full Text] [Related]

  • 18. ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
    Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML.
    Cancer Discov; 2016 Jul 26; 6(7):770-83. PubMed ID: 27154821
    [Abstract] [Full Text] [Related]

  • 19. Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.
    Li BE, Ernst P.
    Exp Hematol; 2014 Dec 26; 42(12):995-1012. PubMed ID: 25264566
    [Abstract] [Full Text] [Related]

  • 20. An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
    Cao F, Chen Y, Cierpicki T, Liu Y, Basrur V, Lei M, Dou Y.
    PLoS One; 2010 Nov 23; 5(11):e14102. PubMed ID: 21124902
    [Abstract] [Full Text] [Related]

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