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125 related items for PubMed ID: 21439986

  • 1. A question of balance--positive versus negative allosteric modulation of GABA(A) receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain.
    Munro G, Erichsen HK, Rae MG, Mirza NR.
    Neuropharmacology; 2011; 61(1-2):121-32. PubMed ID: 21439986
    [Abstract] [Full Text] [Related]

  • 2. Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
    Hansen RR, Erichsen HK, Brown DT, Mirza NR, Munro G.
    Neuropharmacology; 2012 Dec; 63(8):1360-7. PubMed ID: 22985969
    [Abstract] [Full Text] [Related]

  • 3. GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085.
    de Lucas AG, Ahring PK, Larsen JS, Rivera-Arconada I, Lopez-Garcia JA, Mirza NR, Munro G.
    Biochem Pharmacol; 2015 Feb 01; 93(3):370-9. PubMed ID: 25542996
    [Abstract] [Full Text] [Related]

  • 4. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain.
    Munro G, Lopez-Garcia JA, Rivera-Arconada I, Erichsen HK, Nielsen EØ, Larsen JS, Ahring PK, Mirza NR.
    J Pharmacol Exp Ther; 2008 Dec 01; 327(3):969-81. PubMed ID: 18791060
    [Abstract] [Full Text] [Related]

  • 5. Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets.
    Munro G, Ahring PK, Mirza NR.
    Trends Pharmacol Sci; 2009 Sep 01; 30(9):453-9. PubMed ID: 19729210
    [Abstract] [Full Text] [Related]

  • 6. The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
    Munro G, Storm A, Hansen MK, Dyhr H, Marcher L, Erichsen HK, Sheykhzade M.
    Pharmacol Biochem Behav; 2012 May 01; 101(3):465-78. PubMed ID: 22366217
    [Abstract] [Full Text] [Related]

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  • 8. Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem.
    Vinkers CH, Olivier B, Hanania T, Min W, Schreiber R, Hopkins SC, Campbell U, Paterson N.
    Eur J Pharmacol; 2011 Oct 01; 668(1-2):190-3. PubMed ID: 21762686
    [Abstract] [Full Text] [Related]

  • 9. The role of GABA(A) receptor subtypes as analgesic targets.
    Mirza NR, Munro G.
    Drug News Perspect; 2010 Oct 01; 23(6):351-60. PubMed ID: 20697602
    [Abstract] [Full Text] [Related]

  • 10. The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats.
    Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, Yang L, Guo W, Golani LK, Anderson WH, Catlow JT, Jones TM, Porreca F, Smith JL, Knopp KL, Cook JM.
    Pharmacol Biochem Behav; 2019 May 01; 180():22-31. PubMed ID: 30825491
    [Abstract] [Full Text] [Related]

  • 11. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
    Hofmann M, Kordás KS, Gravius A, Bölcskei K, Parsons CG, Dekundy A, Danysz W, Dézsi L, Wittko-Schneider IM, Sághy K, Gyertyán I, Horváth C.
    Behav Pharmacol; 2012 Dec 01; 23(8):790-801. PubMed ID: 23075708
    [Abstract] [Full Text] [Related]

  • 12. Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
    Rode F, Jensen DG, Blackburn-Munro G, Bjerrum OJ.
    Eur J Pharmacol; 2005 Jun 01; 516(2):131-8. PubMed ID: 15936014
    [Abstract] [Full Text] [Related]

  • 13. TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
    Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, Whiting P, Dawson GR, McKernan RM.
    J Pharmacol Exp Ther; 2006 Jan 01; 316(1):410-22. PubMed ID: 16183706
    [Abstract] [Full Text] [Related]

  • 14. Amygdala GABA-A receptor involvement in mediating sensory-discriminative and affective-motivational pain responses in a rat model of peripheral nerve injury.
    Pedersen LH, Scheel-Krüger J, Blackburn-Munro G.
    Pain; 2007 Jan 01; 127(1-2):17-26. PubMed ID: 16965855
    [Abstract] [Full Text] [Related]

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  • 16. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
    Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR.
    J Psychopharmacol; 2007 Jun 01; 21(4):384-91. PubMed ID: 17092983
    [Abstract] [Full Text] [Related]

  • 17. Antinociceptive activity of α4β2* neuronal nicotinic receptor agonist A-366833 in experimental models of neuropathic and inflammatory pain.
    Nirogi R, Jabaris SL, Jayarajan P, Abraham R, Shanmuganathan D, Rasheed MA, Royapalley PK, Goura V.
    Eur J Pharmacol; 2011 Oct 01; 668(1-2):155-62. PubMed ID: 21756895
    [Abstract] [Full Text] [Related]

  • 18. Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023.
    Atack JR.
    Adv Pharmacol; 2009 Oct 01; 57():137-85. PubMed ID: 20230761
    [Abstract] [Full Text] [Related]

  • 19. Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
    Zhu CZ, Chin CL, Rustay NR, Zhong C, Mikusa J, Chandran P, Salyers A, Gomez E, Simler G, Lewis LG, Gauvin D, Baker S, Pai M, Tovcimak A, Brown J, Komater V, Fox GB, Decker MW, Jacobson PB, Gopalakrishnan M, Lee CH, Honore P.
    Biochem Pharmacol; 2011 Oct 15; 82(8):967-76. PubMed ID: 21620806
    [Abstract] [Full Text] [Related]

  • 20. GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Atack JR.
    Curr Top Med Chem; 2011 Oct 15; 11(9):1203-14. PubMed ID: 21050171
    [Abstract] [Full Text] [Related]

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