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524 related items for PubMed ID: 21450749

  • 1. Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis.
    Dees C, Tomcik M, Zerr P, Akhmetshina A, Horn A, Palumbo K, Beyer C, Zwerina J, Distler O, Schett G, Distler JH.
    Ann Rheum Dis; 2011 Jul; 70(7):1304-10. PubMed ID: 21450749
    [Abstract] [Full Text] [Related]

  • 2. Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH.
    Wasson CW, Abignano G, Hermes H, Malaab M, Ross RL, Jimenez SA, Chang HY, Feghali-Bostwick CA, Del Galdo F.
    Ann Rheum Dis; 2020 Apr; 79(4):507-517. PubMed ID: 32041748
    [Abstract] [Full Text] [Related]

  • 3. Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.
    Horn A, Palumbo K, Cordazzo C, Dees C, Akhmetshina A, Tomcik M, Zerr P, Avouac J, Gusinde J, Zwerina J, Roudaut H, Traiffort E, Ruat M, Distler O, Schett G, Distler JH.
    Arthritis Rheum; 2012 Aug; 64(8):2724-33. PubMed ID: 22354771
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.
    Avouac J, Palumbo K, Tomcik M, Zerr P, Dees C, Horn A, Maurer B, Akhmetshina A, Beyer C, Sadowski A, Schneider H, Shiozawa S, Distler O, Schett G, Allanore Y, Distler JH.
    Arthritis Rheum; 2012 May; 64(5):1642-52. PubMed ID: 22139817
    [Abstract] [Full Text] [Related]

  • 5. Notch signaling pathway in keloid disease: enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts.
    Syed F, Bayat A.
    Wound Repair Regen; 2012 May; 20(5):688-706. PubMed ID: 22985040
    [Abstract] [Full Text] [Related]

  • 6. Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.
    Tomcik M, Palumbo-Zerr K, Zerr P, Sumova B, Avouac J, Dees C, Distler A, Becvar R, Distler O, Schett G, Senolt L, Distler JH.
    Ann Rheum Dis; 2016 Mar; 75(3):609-16. PubMed ID: 25603829
    [Abstract] [Full Text] [Related]

  • 7. The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor β and contributes to the development of experimental dermal fibrosis.
    Avouac J, Palumbo-Zerr K, Ruzehaji N, Tomcik M, Zerr P, Dees C, Distler A, Beyer C, Schneider H, Distler O, Schett G, Allanore Y, Distler JH.
    Arthritis Rheumatol; 2014 Nov; 66(11):3140-50. PubMed ID: 25155144
    [Abstract] [Full Text] [Related]

  • 8. Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors.
    Kawaguchi Y, Takagi K, Hara M, Fukasawa C, Sugiura T, Nishimagi E, Harigai M, Kamatani N.
    Arthritis Rheum; 2004 Jan; 50(1):216-26. PubMed ID: 14730619
    [Abstract] [Full Text] [Related]

  • 9. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells.
    Yamamura H, Yamamura A, Ko EA, Pohl NM, Smith KA, Zeifman A, Powell FL, Thistlethwaite PA, Yuan JX.
    Am J Physiol Cell Physiol; 2014 May 01; 306(9):C871-8. PubMed ID: 24573085
    [Abstract] [Full Text] [Related]

  • 10. Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis.
    Zerr P, Palumbo-Zerr K, Huang J, Tomcik M, Sumova B, Distler O, Schett G, Distler JH.
    Ann Rheum Dis; 2016 Jan 01; 75(1):226-33. PubMed ID: 25180292
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.
    Zhang Y, Dees C, Beyer C, Lin NY, Distler A, Zerr P, Palumbo K, Susok L, Kreuter A, Distler O, Schett G, Distler JH.
    Ann Rheum Dis; 2015 May 01; 74(5):936-43. PubMed ID: 24431397
    [Abstract] [Full Text] [Related]

  • 12. Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts.
    Wasson CW, Ross RL, Wells R, Corinaldesi C, Georgiou IC, Riobo-Del Galdo NA, Del Galdo F.
    Arthritis Res Ther; 2020 Dec 10; 22(1):286. PubMed ID: 33303026
    [Abstract] [Full Text] [Related]

  • 13. S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis.
    Tomcik M, Palumbo-Zerr K, Zerr P, Avouac J, Dees C, Sumova B, Distler A, Beyer C, Cerezo LA, Becvar R, Distler O, Grigorian M, Schett G, Senolt L, Distler JH.
    Ann Rheum Dis; 2015 Sep 10; 74(9):1748-55. PubMed ID: 24709861
    [Abstract] [Full Text] [Related]

  • 14. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis.
    Tomcik M, Zerr P, Pitkowski J, Palumbo-Zerr K, Avouac J, Distler O, Becvar R, Senolt L, Schett G, Distler JH.
    Ann Rheum Dis; 2014 Jun 10; 73(6):1215-22. PubMed ID: 23661493
    [Abstract] [Full Text] [Related]

  • 15. Vitamin D receptor regulates TGF-β signalling in systemic sclerosis.
    Zerr P, Vollath S, Palumbo-Zerr K, Tomcik M, Huang J, Distler A, Beyer C, Dees C, Gela K, Distler O, Schett G, Distler JH.
    Ann Rheum Dis; 2015 Mar 10; 74(3):e20. PubMed ID: 24448349
    [Abstract] [Full Text] [Related]

  • 16. An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma.
    Pannu J, Gore-Hyer E, Yamanaka M, Smith EA, Rubinchik S, Dong JY, Jablonska S, Blaszczyk M, Trojanowska M.
    Arthritis Rheum; 2004 May 10; 50(5):1566-77. PubMed ID: 15146427
    [Abstract] [Full Text] [Related]

  • 17. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis.
    Distler JH, Jüngel A, Huber LC, Schulze-Horsel U, Zwerina J, Gay RE, Michel BA, Hauser T, Schett G, Gay S, Distler O.
    Arthritis Rheum; 2007 Jan 10; 56(1):311-22. PubMed ID: 17195235
    [Abstract] [Full Text] [Related]

  • 18. Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts.
    Gore-Hyer E, Pannu J, Smith EA, Grotendorst G, Trojanowska M.
    Arthritis Rheum; 2003 Mar 10; 48(3):798-806. PubMed ID: 12632435
    [Abstract] [Full Text] [Related]

  • 19. Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts.
    Nakashima T, Jinnin M, Yamane K, Honda N, Kajihara I, Makino T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
    J Immunol; 2012 Apr 15; 188(8):3573-83. PubMed ID: 22403442
    [Abstract] [Full Text] [Related]

  • 20. Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts.
    Cutolo M, Ruaro B, Montagna P, Brizzolara R, Stratta E, Trombetta AC, Scabini S, Tavilla PP, Parodi A, Corallo C, Giordano N, Paolino S, Pizzorni C, Sulli A, Smith V, Soldano S.
    Arthritis Res Ther; 2018 May 02; 20(1):77. PubMed ID: 29720235
    [Abstract] [Full Text] [Related]

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