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Journal Abstract Search

389 related items for PubMed ID: 21466440

  • 1. GCH1, BH4 and pain.
    Latremoliere A, Costigan M.
    Curr Pharm Biotechnol; 2011 Oct; 12(10):1728-41. PubMed ID: 21466440
    [Abstract] [Full Text] [Related]

  • 2. Analgesia by inhibiting tetrahydrobiopterin synthesis.
    Costigan M, Latremoliere A, Woolf CJ.
    Curr Opin Pharmacol; 2012 Feb; 12(1):92-9. PubMed ID: 22178186
    [Abstract] [Full Text] [Related]

  • 3. Mast cell tetrahydrobiopterin contributes to itch in mice.
    Zschiebsch K, Fischer C, Wilken-Schmitz A, Geisslinger G, Channon K, Watschinger K, Tegeder I.
    J Cell Mol Med; 2019 Feb; 23(2):985-1000. PubMed ID: 30450838
    [Abstract] [Full Text] [Related]

  • 4. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
    Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ.
    Nat Med; 2006 Nov; 12(11):1269-77. PubMed ID: 17057711
    [Abstract] [Full Text] [Related]

  • 5. The neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons.
    Kapatos G.
    IUBMB Life; 2013 Apr; 65(4):323-33. PubMed ID: 23457032
    [Abstract] [Full Text] [Related]

  • 6. Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
    Hussein D, Starr A, Heikal L, McNeill E, Channon KM, Brown PR, Sutton BJ, McDonnell JM, Nandi M.
    Br J Pharmacol; 2015 Aug; 172(16):4146-57. PubMed ID: 26014146
    [Abstract] [Full Text] [Related]

  • 7. Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
    Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJ.
    Sci Transl Med; 2022 Aug 31; 14(660):eabj1531. PubMed ID: 36044597
    [Abstract] [Full Text] [Related]

  • 8. Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
    McNeill E, Crabtree MJ, Sahgal N, Patel J, Chuaiphichai S, Iqbal AJ, Hale AB, Greaves DR, Channon KM.
    Free Radic Biol Med; 2015 Feb 31; 79():206-16. PubMed ID: 25451639
    [Abstract] [Full Text] [Related]

  • 9. Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
    Nasser A, Bjerrum OJ, Heegaard AM, Møller AT, Larsen M, Dalbøge LS, Dupont E, Jensen TS, Møller LB.
    Mol Pain; 2013 Feb 19; 9():5. PubMed ID: 23421753
    [Abstract] [Full Text] [Related]

  • 10. GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial-tachypacing via tetrahydrobiopterin pathway regulated by microRNA-206.
    Wei J, Zhang Y, Li Z, Wang X, Chen L, Du J, Liu J, Liu J, Hou Y.
    Pacing Clin Electrophysiol; 2018 May 19; 41(5):459-471. PubMed ID: 29436714
    [Abstract] [Full Text] [Related]

  • 11. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
    Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM.
    J Am Coll Cardiol; 2008 Jul 08; 52(2):158-65. PubMed ID: 18598896
    [Abstract] [Full Text] [Related]

  • 12. Regulation of cortical and peripheral GCH1 expression and biopterin levels in schizophrenia-spectrum disorders.
    Clelland JD, Read LL, Smeed J, Clelland CL.
    Psychiatry Res; 2018 Apr 08; 262():229-236. PubMed ID: 29471261
    [Abstract] [Full Text] [Related]

  • 13. A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
    Douglas G, Hale AB, Crabtree MJ, Ryan BJ, Hansler A, Watschinger K, Gross SS, Lygate CA, Alp NJ, Channon KM.
    Dev Biol; 2015 Mar 01; 399(1):129-138. PubMed ID: 25557619
    [Abstract] [Full Text] [Related]

  • 14. Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.
    Nasser A, Møller AT, Hellmund V, Thorborg SS, Jespersgaard C, Bjerrum OJ, Dupont E, Nachman G, Lykkesfeldt J, Jensen TS, Møller LB.
    Pain; 2018 Jun 01; 159(6):1012-1024. PubMed ID: 29470312
    [Abstract] [Full Text] [Related]

  • 15. The tetrahydrobiopterin pathway and pain.
    Naylor AM, Pojasek KR, Hopkins AL, Blagg J.
    Curr Opin Investig Drugs; 2010 Jan 01; 11(1):19-30. PubMed ID: 20047156
    [Abstract] [Full Text] [Related]

  • 16. Combining Human and Rodent Genetics to Identify New Analgesics.
    Latremoliere A, Costigan M.
    Neurosci Bull; 2018 Feb 01; 34(1):143-155. PubMed ID: 28667479
    [Abstract] [Full Text] [Related]

  • 17. Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
    Shimizu S, Shiota K, Yamamoto S, Miyasaka Y, Ishii M, Watabe T, Nishida M, Mori Y, Yamamoto T, Kiuchi Y.
    Free Radic Biol Med; 2003 May 15; 34(10):1343-52. PubMed ID: 12726922
    [Abstract] [Full Text] [Related]

  • 18. Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
    Antoniades C, Cunnington C, Antonopoulos A, Neville M, Margaritis M, Demosthenous M, Bendall J, Hale A, Cerrato R, Tousoulis D, Bakogiannis C, Marinou K, Toutouza M, Vlachopoulos C, Leeson P, Stefanadis C, Karpe F, Channon KM.
    Circulation; 2011 Oct 25; 124(17):1860-70. PubMed ID: 21969008
    [Abstract] [Full Text] [Related]

  • 19. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
    Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ.
    Neuron; 2015 Jun 17; 86(6):1393-406. PubMed ID: 26087165
    [Abstract] [Full Text] [Related]

  • 20. Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.
    Tegeder I, Adolph J, Schmidt H, Woolf CJ, Geisslinger G, Lötsch J.
    Eur J Pain; 2008 Nov 17; 12(8):1069-77. PubMed ID: 18374612
    [Abstract] [Full Text] [Related]

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