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121 related items for PubMed ID: 21482467

  • 1. Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
    Young RJ, Alderton W, Angell AD, Beswick PJ, Brown D, Chambers CL, Crowe MC, Dawson J, Hamlett CC, Hodgson ST, Kleanthous S, Knowles RG, Russell LJ, Stocker R, Woolven JM.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3037-40. PubMed ID: 21482467
    [Abstract] [Full Text] [Related]

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  • 3. 1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence.
    López-Cara LC, Carrión MD, Entrena A, Gallo MA, Espinosa A, López A, Escames G, Acuña-Castroviejo D, Camacho ME.
    Eur J Med Chem; 2012 Apr 15; 50():129-39. PubMed ID: 22336385
    [Abstract] [Full Text] [Related]

  • 4. N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.
    Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES.
    J Med Chem; 1998 Jul 16; 41(15):2858-71. PubMed ID: 9667974
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.
    Maccallini C, Patruno A, Besker N, Alì JI, Ammazzalorso A, De Filippis B, Franceschelli S, Giampietro L, Pesce M, Reale M, Tricca ML, Re N, Felaco M, Amoroso R.
    J Med Chem; 2009 Mar 12; 52(5):1481-5. PubMed ID: 19203270
    [Abstract] [Full Text] [Related]

  • 6. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC, Camacho ME, Carrión MD, Tapias V, Gallo MA, Escames G, Acuña-Castroviejo D, Espinosa A, Entrena A.
    Eur J Med Chem; 2009 Jun 12; 44(6):2655-66. PubMed ID: 19117642
    [Abstract] [Full Text] [Related]

  • 7. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.
    Strub A, Ulrich WR, Hesslinger C, Eltze M, Fuchss T, Strassner J, Strand S, Lehner MD, Boer R.
    Mol Pharmacol; 2006 Jan 12; 69(1):328-37. PubMed ID: 16223957
    [Abstract] [Full Text] [Related]

  • 8. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).
    Carrión MD, López Cara LC, Camacho ME, Tapias V, Escames G, Acuña-Castroviejo D, Espinosa A, Gallo MA, Entrena A.
    Eur J Med Chem; 2008 Nov 12; 43(11):2579-91. PubMed ID: 18325637
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group.
    Carrión MD, Chayah M, Entrena A, López A, Gallo MA, Acuña-Castroviejo D, Camacho ME.
    Bioorg Med Chem; 2013 Jul 15; 21(14):4132-42. PubMed ID: 23735830
    [Abstract] [Full Text] [Related]

  • 10. Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine.
    Maccallini C, Patruno A, Ammazzalorso A, De Filippis B, Fantacuzzi M, Franceschelli S, Giampietro L, Masella S, Tricca ML, Amoroso R.
    Med Chem; 2012 Nov 15; 8(6):991-5. PubMed ID: 22741778
    [Abstract] [Full Text] [Related]

  • 11. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2009 May 14; 52(9):3047-62. PubMed ID: 19374401
    [Abstract] [Full Text] [Related]

  • 12. Selective inhibition of iNOS by benzyl- and dibenzyl derivatives of N-(3-aminobenzyl)acetamidine.
    Fantacuzzi M, Maccallini C, Lannutti F, Patruno A, Masella S, Pesce M, Speranza L, Ammazzalorso A, De Filippis B, Giampietro L, Re N, Amoroso R.
    ChemMedChem; 2011 Jul 04; 6(7):1203-6. PubMed ID: 21567968
    [No Abstract] [Full Text] [Related]

  • 13. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
    Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ.
    Mol Pharmacol; 2008 Apr 04; 73(4):1244-53. PubMed ID: 18178668
    [Abstract] [Full Text] [Related]

  • 14. Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors.
    Arias F, Franco-Montalban F, Romero M, Carrión MD, Camacho ME.
    Bioorg Med Chem; 2021 Aug 15; 44():116294. PubMed ID: 34218000
    [Abstract] [Full Text] [Related]

  • 15. 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
    Lee Y, Martásek P, Roman LJ, Silverman RB.
    Bioorg Med Chem Lett; 2000 Dec 18; 10(24):2771-4. PubMed ID: 11133088
    [Abstract] [Full Text] [Related]

  • 16. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
    Hah JM, Martásek P, Roman LJ, Silverman RB.
    J Med Chem; 2003 Apr 24; 46(9):1661-9. PubMed ID: 12699384
    [Abstract] [Full Text] [Related]

  • 17. 1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
    Wei RG, Adler M, Davey D, Ho E, Mohan R, Polokoff M, Tseng JL, Whitlow M, Xu W, Yuan S, Phillips G.
    Bioorg Med Chem Lett; 2007 May 01; 17(9):2499-504. PubMed ID: 17368901
    [Abstract] [Full Text] [Related]

  • 18. Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.
    Maccallini C, Di Matteo M, Gallorini M, Montagnani M, Graziani V, Ammazzalorso A, Amoia P, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Cataldi A, Amoroso R.
    Eur J Med Chem; 2018 May 25; 152():53-64. PubMed ID: 29689474
    [Abstract] [Full Text] [Related]

  • 19. Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing.
    Guo JS, Cho CH, Wang JY, Koo MW.
    Eur J Pharmacol; 2006 May 01; 536(3):301-8. PubMed ID: 16600210
    [Abstract] [Full Text] [Related]

  • 20. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
    Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2468-71. PubMed ID: 21398123
    [Abstract] [Full Text] [Related]

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