These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

229 related items for PubMed ID: 21502194

  • 1. Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and back.
    Halpert JR.
    Drug Metab Dispos; 2011 Jul; 39(7):1113-21. PubMed ID: 21502194
    [Abstract] [Full Text] [Related]

  • 2. Structure-function analysis of cytochromes P450 2B.
    Zhao Y, Halpert JR.
    Biochim Biophys Acta; 2007 Mar; 1770(3):402-12. PubMed ID: 16935426
    [Abstract] [Full Text] [Related]

  • 3. Plasticity of CYP2B enzymes: structural and solution biophysical methods.
    Wilderman PR, Halpert JR.
    Curr Drug Metab; 2012 Feb; 13(2):167-76. PubMed ID: 22208531
    [Abstract] [Full Text] [Related]

  • 4. Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.
    Gay SC, Roberts AG, Halpert JR.
    Future Med Chem; 2010 Sep; 2(9):1451-68. PubMed ID: 21103389
    [Abstract] [Full Text] [Related]

  • 5. Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.
    Lewis DF, Lake BG, Dickins M, Eddershaw PJ, Tarbit MH, Goldfarb PS.
    Xenobiotica; 1999 Apr; 29(4):361-93. PubMed ID: 10375007
    [Abstract] [Full Text] [Related]

  • 6. A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states.
    Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR.
    J Pharmacol Exp Ther; 2013 Jul; 346(1):113-20. PubMed ID: 23633618
    [Abstract] [Full Text] [Related]

  • 7. Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.
    Basudhar D, Madrona Y, Kandel S, Lampe JN, Nishida CR, de Montellano PR.
    J Biol Chem; 2015 Apr 17; 290(16):10000-17. PubMed ID: 25670859
    [Abstract] [Full Text] [Related]

  • 8. What Your Crystal Structure Will Not Tell You about Enzyme Function.
    Pochapsky TC, Pochapsky SS.
    Acc Chem Res; 2019 May 21; 52(5):1409-1418. PubMed ID: 31034199
    [Abstract] [Full Text] [Related]

  • 9. Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.
    Wilderman PR, Jang HH, Malenke JR, Salib M, Angermeier E, Lamime S, Dearing MD, Halpert JR.
    Toxicol Appl Pharmacol; 2014 Feb 01; 274(3):393-401. PubMed ID: 24361551
    [Abstract] [Full Text] [Related]

  • 10. Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.
    Talakad JC, Shah MB, Walker GS, Xiang C, Halpert JR, Dalvie D.
    Drug Metab Dispos; 2011 Mar 01; 39(3):539-50. PubMed ID: 21156812
    [Abstract] [Full Text] [Related]

  • 11. Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.
    Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR.
    Mol Pharmacol; 2011 Dec 01; 80(6):1047-55. PubMed ID: 21875942
    [Abstract] [Full Text] [Related]

  • 12. Cytochrome P450 structure-function: insights from molecular dynamics simulations.
    Nair PC, McKinnon RA, Miners JO.
    Drug Metab Rev; 2016 Aug 01; 48(3):434-52. PubMed ID: 27167388
    [Abstract] [Full Text] [Related]

  • 13. Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium.
    Jóźwik IK, Kiss FM, Gricman Ł, Abdulmughni A, Brill E, Zapp J, Pleiss J, Bernhardt R, Thunnissen AW.
    FEBS J; 2016 Nov 01; 283(22):4128-4148. PubMed ID: 27686671
    [Abstract] [Full Text] [Related]

  • 14. Progress in cytochrome P450 active site modeling.
    Kemp CA, Maréchal JD, Sutcliffe MJ.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):361-8. PubMed ID: 15581592
    [Abstract] [Full Text] [Related]

  • 15. Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes.
    Zhang H, Lin HL, Kenaan C, Hollenberg PF.
    Arch Biochem Biophys; 2011 Mar 01; 507(1):135-43. PubMed ID: 20836985
    [Abstract] [Full Text] [Related]

  • 16. Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
    Kumar S, Zhao Y, Sun L, Negi SS, Halpert JR, Muralidhara BK.
    Mol Pharmacol; 2007 Nov 01; 72(5):1191-9. PubMed ID: 17715394
    [Abstract] [Full Text] [Related]

  • 17. Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences.
    Lewis DF, Ito Y, Lake BG.
    J Enzyme Inhib Med Chem; 2010 Oct 01; 25(5):679-84. PubMed ID: 20100069
    [Abstract] [Full Text] [Related]

  • 18. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.
    Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR.
    Biochemistry; 2016 Apr 05; 55(13):1997-2007. PubMed ID: 26982502
    [Abstract] [Full Text] [Related]

  • 19. Crystal structure of bacterial CYP116B5 heme domain: New insights on class VII P450s structural flexibility and peroxygenase activity.
    Ciaramella A, Catucci G, Gilardi G, Di Nardo G.
    Int J Biol Macromol; 2019 Nov 01; 140():577-587. PubMed ID: 31430491
    [Abstract] [Full Text] [Related]

  • 20. Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.
    Lewis DF, Ito Y.
    Xenobiotica; 2009 Aug 01; 39(8):625-35. PubMed ID: 19514836
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 12.