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304 related items for PubMed ID: 21503588

  • 1. Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable.
    Suda T, Yoshihara M, Nakamura Y, Sekiguchi H, Godai TI, Sugano N, Tsuchida K, Shiozawa M, Sakuma Y, Tsuchiya E, Kameda Y, Akaike M, Matsukuma S, Miyagi Y.
    Oncol Rep; 2011 Jul; 26(1):49-54. PubMed ID: 21503588
    [Abstract] [Full Text] [Related]

  • 2. High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53.
    Veerakumarasivam A, Scott HE, Chin SF, Warren A, Wallard MJ, Grimmer D, Ichimura K, Caldas C, Collins VP, Neal DE, Kelly JD.
    Clin Cancer Res; 2008 May 01; 14(9):2527-34. PubMed ID: 18451213
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  • 3. Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
    Riemenschneider MJ, Büschges R, Wolter M, Reifenberger J, Boström J, Kraus JA, Schlegel U, Reifenberger G.
    Cancer Res; 1999 Dec 15; 59(24):6091-6. PubMed ID: 10626796
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  • 4. MDM2 and MDM4: p53 regulators as targets in anticancer therapy.
    Toledo F, Wahl GM.
    Int J Biochem Cell Biol; 2007 Dec 15; 39(7-8):1476-82. PubMed ID: 17499002
    [Abstract] [Full Text] [Related]

  • 5. MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers.
    Forslund A, Zeng Z, Qin LX, Rosenberg S, Ndubuisi M, Pincas H, Gerald W, Notterman DA, Barany F, Paty PB.
    Mol Cancer Res; 2008 Feb 15; 6(2):205-11. PubMed ID: 18314481
    [Abstract] [Full Text] [Related]

  • 6. TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases.
    Leventaki V, Rodic V, Tripp SR, Bayerl MG, Perkins SL, Barnette P, Schiffman JD, Miles RR.
    Br J Haematol; 2012 Sep 15; 158(6):763-71. PubMed ID: 22845047
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  • 9. The expression of MDM2, MDM4, p53 and p21 in myeloid neoplasms and the effect of MDM2/MDM4 dual inhibitor.
    Eskandari M, Shi Y, Liu J, Albanese J, Goel S, Verma A, Wang Y.
    Leuk Lymphoma; 2021 Jan 15; 62(1):167-175. PubMed ID: 32924682
    [Abstract] [Full Text] [Related]

  • 10. Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer.
    Ach T, Schwarz-Furlan S, Ach S, Agaimy A, Gerken M, Rohrmeier C, Zenk J, Iro H, Brockhoff G, Ettl T.
    J Oral Pathol Med; 2016 Aug 15; 45(7):500-9. PubMed ID: 26661925
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  • 11. Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis.
    Ito M, Barys L, O'Reilly T, Young S, Gorbatcheva B, Monahan J, Zumstein-Mecker S, Choong PF, Dickinson I, Crowe P, Hemmings C, Desai J, Thomas DM, Lisztwan J.
    Clin Cancer Res; 2011 Feb 01; 17(3):416-26. PubMed ID: 21159888
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  • 12. Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.
    Park DE, Cheng J, Berrios C, Montero J, Cortés-Cros M, Ferretti S, Arora R, Tillgren ML, Gokhale PC, DeCaprio JA.
    Proc Natl Acad Sci U S A; 2019 Jan 15; 116(3):1027-1032. PubMed ID: 30598450
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  • 13. MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation.
    Qi DL, Cobrinik D.
    Oncogene; 2017 Mar 30; 36(13):1760-1769. PubMed ID: 27748758
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  • 14. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.
    Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM.
    Cancer Cell; 2006 Apr 30; 9(4):273-85. PubMed ID: 16616333
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  • 15. Mdm2 gene amplification in gastric cancer correlation with expression of Mdm2 protein and p53 alterations.
    Günther T, Schneider-Stock R, Häckel C, Kasper HU, Pross M, Hackelsberger A, Lippert H, Roessner A.
    Mod Pathol; 2000 Jun 30; 13(6):621-6. PubMed ID: 10874665
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  • 17. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
    Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G, Bellefroid E, Marine JC.
    Proc Natl Acad Sci U S A; 2006 Feb 28; 103(9):3232-7. PubMed ID: 16492744
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  • 18. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.
    Toledo F, Wahl GM.
    Nat Rev Cancer; 2006 Dec 28; 6(12):909-23. PubMed ID: 17128209
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  • 19. Distinctive patterns of p53 protein expression and microsatellite instability in human colorectal cancer.
    Nyiraneza C, Jouret-Mourin A, Kartheuser A, Camby P, Plomteux O, Detry R, Dahan K, Sempoux C.
    Hum Pathol; 2011 Dec 28; 42(12):1897-910. PubMed ID: 21665242
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  • 20. Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling.
    Pishas KI, Neuhaus SJ, Clayer MT, Schreiber AW, Lawrence DM, Perugini M, Whitfield RJ, Farshid G, Manavis J, Chryssidis S, Mayo BJ, Haycox RC, Ho K, Brown MP, D'Andrea RJ, Evdokiou A, Thomas DM, Desai J, Callen DF, Neilsen PM.
    Cancer Res; 2014 Feb 01; 74(3):921-31. PubMed ID: 24336067
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