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Journal Abstract Search

287 related items for PubMed ID: 21511943

  • 1.
    ; . PubMed ID:
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  • 2. Pharmacokinetics, metabolism, and disposition of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys.
    Uchiyama M, Iwabuchi H, Tsuruta F, Abe K, Takahashi M, Koda H, Oguchi M, Okazaki O, Izumi T.
    Drug Metab Dispos; 2011 Apr; 39(4):653-66. PubMed ID: 21177486
    [Abstract] [Full Text] [Related]

  • 3. Identification of novel metabolic pathways of pioglitazone in hepatocytes: N-glucuronidation of thiazolidinedione ring and sequential ring-opening pathway.
    Uchiyama M, Fischer T, Mueller J, Oguchi M, Yamamura N, Koda H, Iwabuchi H, Izumi T.
    Drug Metab Dispos; 2010 Jun; 38(6):946-56. PubMed ID: 20185540
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  • 5. In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry.
    Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE.
    Drug Metab Dispos; 2004 Sep; 32(9):1023-31. PubMed ID: 15319345
    [Abstract] [Full Text] [Related]

  • 6. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC, Vashishtha SC, DeMaio W, Talaat RE.
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
    [Abstract] [Full Text] [Related]

  • 7. Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist.
    Karanam BV, Welch CJ, Reddy VG, Chilenski J, Biba M, Vincent S.
    Drug Metab Dispos; 2004 Oct; 32(10):1061-8. PubMed ID: 15229170
    [Abstract] [Full Text] [Related]

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  • 9. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
    Lang D, Freudenberger C, Weinz C.
    Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846
    [Abstract] [Full Text] [Related]

  • 10. Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.
    Kochansky CJ, Xia YQ, Wang S, Cato B, Creighton M, Vincent SH, Franklin RB, Reed JR.
    Drug Metab Dispos; 2005 Dec; 33(12):1894-904. PubMed ID: 16183782
    [Abstract] [Full Text] [Related]

  • 11. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
    Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG.
    Drug Metab Dispos; 2007 Jan; 35(1):139-49. PubMed ID: 17062778
    [Abstract] [Full Text] [Related]

  • 12. Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey.
    Johnson BM, Kamath AV, Leet JE, Liu X, Bhide RS, Tejwani RW, Zhang Y, Qian L, Wei DD, Lombardo LJ, Shu YZ.
    Drug Metab Dispos; 2008 Dec; 36(12):2475-83. PubMed ID: 18787055
    [Abstract] [Full Text] [Related]

  • 13. An unusual metabolic pathway of sipoglitazar, a novel antidiabetic agent: cytochrome P450-catalyzed oxidation of sipoglitazar acyl glucuronide.
    Nishihara M, Sudo M, Kawaguchi N, Takahashi J, Kiyota Y, Kondo T, Asahi S.
    Drug Metab Dispos; 2012 Feb; 40(2):249-58. PubMed ID: 22028317
    [Abstract] [Full Text] [Related]

  • 14. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
    Reddy VB, Karanam BV, Gruber WL, Wallace MA, Vincent SH, Franklin RB, Baillie TA.
    Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
    [Abstract] [Full Text] [Related]

  • 15. In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology.
    Schulz-Utermoehl T, Spear M, Pollard CR, Pattison C, Rollison H, Sarda S, Ward M, Bushby N, Jordan A, Harrison M.
    Drug Metab Dispos; 2010 Oct; 38(10):1688-97. PubMed ID: 20634336
    [Abstract] [Full Text] [Related]

  • 16. Identification of BVT.2938 metabolites by LC/MS and LC/MS/MS after in vitro incubations with liver microsomes and hepatocytes.
    Edlund PO, Baranczewski P.
    J Pharm Biomed Anal; 2004 Mar 10; 34(5):1079-90. PubMed ID: 15019042
    [Abstract] [Full Text] [Related]

  • 17. Metabolic activation of pioglitazone identified from rat and human liver microsomes and freshly isolated hepatocytes.
    Baughman TM, Graham RA, Wells-Knecht K, Silver IS, Tyler LO, Wells-Knecht M, Zhao Z.
    Drug Metab Dispos; 2005 Jun 10; 33(6):733-8. PubMed ID: 15764718
    [Abstract] [Full Text] [Related]

  • 18. Characterization of 2-[[4-[[2-(1H-tetrazol-5-ylmethyl)phenyl]methoxy]methyl]quinoline N-glucuronidation by in vitro and in vivo approaches.
    Stevens JC, Fayer JL, Cassidy KC.
    Drug Metab Dispos; 2001 Mar 10; 29(3):289-95. PubMed ID: 11181497
    [Abstract] [Full Text] [Related]

  • 19. Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical species and human.
    Frederick KS, Maurer TS, Kalgutkar AS, Royer LJ, Francone OL, Winter SM, Terra SG, Chen D, Gao X.
    Xenobiotica; 2009 Oct 10; 39(10):766-81. PubMed ID: 19622022
    [Abstract] [Full Text] [Related]

  • 20. In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.
    Agrawal AK, Hop CE, Pang J, Silva Elipe MV, Desai RC, Leung KH, Franklin RB.
    J Pharm Biomed Anal; 2005 Feb 23; 37(2):351-8. PubMed ID: 15708677
    [Abstract] [Full Text] [Related]

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