These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

129 related items for PubMed ID: 21532165

  • 1. In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone.
    Matsumoto K, Nemoto E, Hasegawa T, Akimoto M, Sugibayashi K.
    Biol Pharm Bull; 2011; 34(5):734-9. PubMed ID: 21532165
    [Abstract] [Full Text] [Related]

  • 2. A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes.
    Turpeinen M, Hofmann U, Klein K, Mürdter T, Schwab M, Zanger UM.
    Drug Metab Dispos; 2009 May; 37(5):1017-24. PubMed ID: 19204080
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure.
    Kumpulainen H, Mähönen N, Laitinen ML, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J.
    J Med Chem; 2006 Feb 09; 49(3):1207-11. PubMed ID: 16451086
    [Abstract] [Full Text] [Related]

  • 4. Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro.
    Matsumoto K, Hasegawa T, Ohara K, Kamei T, Koyanagi J, Akimoto M.
    Xenobiotica; 2021 Feb 09; 51(2):155-166. PubMed ID: 33146575
    [Abstract] [Full Text] [Related]

  • 5. A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes.
    Matsumoto K, Hasegawa T, Ohara K, Takei C, Kamei T, Koyanagi J, Takahashi T, Akimoto M.
    Xenobiotica; 2020 Jul 09; 50(7):783-792. PubMed ID: 31855101
    [Abstract] [Full Text] [Related]

  • 6. Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies: identification of new nabumetone metabolites.
    Nobilis M, Mikušek J, Szotáková B, Jirásko R, Holčapek M, Chamseddin C, Jira T, Kučera R, Kuneš J, Pour M.
    J Pharm Biomed Anal; 2013 Jun 09; 80():164-72. PubMed ID: 23584048
    [Abstract] [Full Text] [Related]

  • 7. Carbon-carbon bond cleavage in activation of the prodrug nabumetone.
    Varfaj F, Zulkifli SN, Park HG, Challinor VL, De Voss JJ, Ortiz de Montellano PR.
    Drug Metab Dispos; 2014 May 09; 42(5):828-38. PubMed ID: 24584631
    [Abstract] [Full Text] [Related]

  • 8. Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor.
    Tang C, Shou M, Mei Q, Rushmore TH, Rodrigues AD.
    J Pharmacol Exp Ther; 2000 May 09; 293(2):453-9. PubMed ID: 10773015
    [Abstract] [Full Text] [Related]

  • 9. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
    Eagling VA, Tjia JF, Back DJ.
    Br J Clin Pharmacol; 1998 Feb 09; 45(2):107-14. PubMed ID: 9491822
    [Abstract] [Full Text] [Related]

  • 10. The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes.
    Akimoto M, Iida I, Itoga H, Miyata A, Kawahara S, Kohno Y.
    Eur J Drug Metab Pharmacokinet; 2004 Feb 09; 29(3):179-86. PubMed ID: 15537169
    [Abstract] [Full Text] [Related]

  • 11. Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.
    Narimatsu S, Yonemoto R, Saito K, Takaya K, Kumamoto T, Ishikawa T, Asanuma M, Funada M, Kiryu K, Naito S, Yoshida Y, Yamamoto S, Hanioka N.
    Biochem Pharmacol; 2006 Apr 28; 71(9):1377-85. PubMed ID: 16510126
    [Abstract] [Full Text] [Related]

  • 12. In vitro characterization of 4'-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s.
    Lee B, Wu Z, Lee T, Tan XF, Park KH, Liu KH.
    Xenobiotica; 2016 Apr 28; 46(4):350-6. PubMed ID: 26330107
    [Abstract] [Full Text] [Related]

  • 13. Effect of the antiinflammatory prodrug, nabumetone and its principal active metabolite on rat gastric mucosal, aortic and platelet eicosanoid synthesis, in vitro and ex vivo.
    Jeremy JY, Thompson CS, Mikhailidis DP, Dandona P.
    Prostaglandins Leukot Essent Fatty Acids; 1990 Nov 28; 41(3):195-9. PubMed ID: 2281122
    [Abstract] [Full Text] [Related]

  • 14. Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.
    Pan LP, Wijnant P, De Vriendt C, Rosseel MT, Belpaire FM.
    Br J Clin Pharmacol; 1997 Dec 28; 44(6):557-64. PubMed ID: 9431831
    [Abstract] [Full Text] [Related]

  • 15. Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug.
    Generaux CN, Ainslie GR, Bridges AS, Ismail MA, Boykin DW, Tidwell RR, Thakker DR, Paine MF.
    Drug Metab Dispos; 2013 Feb 28; 41(2):518-28. PubMed ID: 23223498
    [Abstract] [Full Text] [Related]

  • 16. Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.
    Ghosal A, Satoh H, Thomas PE, Bush E, Moore D.
    Drug Metab Dispos; 1996 Sep 28; 24(9):940-7. PubMed ID: 8886602
    [Abstract] [Full Text] [Related]

  • 17. Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid.
    Zhou S, Paxton JW, Tingle MD, Kestell P.
    Drug Metab Dispos; 2000 Dec 28; 28(12):1449-56. PubMed ID: 11095582
    [Abstract] [Full Text] [Related]

  • 18. Evidence for the involvement of human liver microsomes CYP1A2 in the mono-hydroxylation of daidzein.
    Peng WX, Wang LS, Li HD, Abd El-Aty AM, Chen GL, Zhou HH.
    Clin Chim Acta; 2003 Aug 28; 334(1-2):77-85. PubMed ID: 12867277
    [Abstract] [Full Text] [Related]

  • 19. Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes.
    Komatsu T, Yamazaki H, Shimada N, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2000 Dec 28; 28(12):1457-63. PubMed ID: 11095583
    [Abstract] [Full Text] [Related]

  • 20. Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
    Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T.
    J Pharmacol Exp Ther; 1996 Dec 28; 279(3):1327-34. PubMed ID: 8968357
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 7.