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Journal Abstract Search

140 related items for PubMed ID: 21542861

  • 1. The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
    Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.
    Mol Microbiol; 2011 Jul; 81(1):143-56. PubMed ID: 21542861
    [Abstract] [Full Text] [Related]

  • 2. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
    Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
    Biochem J; 2010 Oct 15; 431(2):207-16. PubMed ID: 20704566
    [Abstract] [Full Text] [Related]

  • 3. Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.
    Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
    Proc Natl Acad Sci U S A; 2007 Jan 02; 104(1):359-64. PubMed ID: 17185412
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  • 4. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.
    Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, Beermann S, Karnath T, Bigalke H, Binz T.
    J Neurochem; 2009 Sep 02; 110(6):1942-54. PubMed ID: 19650874
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  • 5. Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
    Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT.
    J Biol Chem; 2012 Nov 23; 287(48):40806-16. PubMed ID: 23027864
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  • 6. Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.
    Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong M.
    Nat Commun; 2017 Nov 21; 8(1):1637. PubMed ID: 29158482
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  • 7. Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
    Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC.
    Nature; 2006 Dec 21; 444(7122):1096-100. PubMed ID: 17167418
    [Abstract] [Full Text] [Related]

  • 8. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    FEBS J; 2011 Dec 21; 278(23):4506-15. PubMed ID: 21624052
    [Abstract] [Full Text] [Related]

  • 9. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.
    Rummel A.
    Curr Top Microbiol Immunol; 2013 Dec 21; 364():61-90. PubMed ID: 23239349
    [Abstract] [Full Text] [Related]

  • 10. Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F.
    Fu Z, Chen C, Barbieri JT, Kim JJ, Baldwin MR.
    Biochemistry; 2009 Jun 23; 48(24):5631-41. PubMed ID: 19476346
    [Abstract] [Full Text] [Related]

  • 11. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.
    Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.
    Biochemistry; 2013 Jun 04; 52(22):3930-8. PubMed ID: 23647335
    [Abstract] [Full Text] [Related]

  • 12. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
    Jin R, Rummel A, Binz T, Brunger AT.
    Nature; 2006 Dec 21; 444(7122):1092-5. PubMed ID: 17167421
    [Abstract] [Full Text] [Related]

  • 13. Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
    Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT.
    J Biol Chem; 2011 Jul 29; 286(30):26828-37. PubMed ID: 21632541
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  • 15. The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    Mol Microbiol; 2004 Feb 29; 51(3):631-43. PubMed ID: 14731268
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  • 19. Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: insight into the ganglioside binding mechanism.
    Nuemket N, Tanaka Y, Tsukamoto K, Tsuji T, Nakamura K, Kozaki S, Yao M, Tanaka I.
    Biochem Biophys Res Commun; 2011 Jul 29; 411(2):433-9. PubMed ID: 21749855
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  • 20. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.
    Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.
    Toxicon; 2013 Dec 01; 75():108-21. PubMed ID: 23817019
    [Abstract] [Full Text] [Related]

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