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Journal Abstract Search

158 related items for PubMed ID: 21555506

  • 1. The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
    Potega A, Dabrowska E, Niemira M, Kot-Wasik A, Ronseaux S, Henderson CJ, Wolf CR, Mazerska Z.
    Drug Metab Dispos; 2011 Aug; 39(8):1423-32. PubMed ID: 21555506
    [Abstract] [Full Text] [Related]

  • 2. Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
    Fedejko-Kap B, Niemira M, Radominska-Pandya A, Mazerska Z.
    Xenobiotica; 2011 Dec; 41(12):1044-55. PubMed ID: 21859392
    [Abstract] [Full Text] [Related]

  • 3. Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
    Rawden HC, Kokwaro GO, Ward SA, Edwards G.
    Br J Clin Pharmacol; 2000 Apr; 49(4):313-22. PubMed ID: 10759686
    [Abstract] [Full Text] [Related]

  • 4. Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase.
    Kousba A, Soll R, Yee S, Martin M.
    Drug Metab Dispos; 2007 Dec; 35(12):2242-51. PubMed ID: 17881660
    [Abstract] [Full Text] [Related]

  • 5. Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
    Fedejko-Kap B, Bratton SM, Finel M, Radominska-Pandya A, Mazerska Z.
    Drug Metab Dispos; 2012 Sep; 40(9):1736-43. PubMed ID: 22659092
    [Abstract] [Full Text] [Related]

  • 6. S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomes.
    Ohmi N, Yoshida H, Endo H, Hasegawa M, Akimoto M, Higuchi S.
    Xenobiotica; 2003 Dec; 33(12):1221-31. PubMed ID: 14742144
    [Abstract] [Full Text] [Related]

  • 7. In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms.
    Lang DH, Rettie AE.
    Br J Clin Pharmacol; 2000 Oct; 50(4):311-4. PubMed ID: 11012553
    [Abstract] [Full Text] [Related]

  • 8. Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.
    Taniguchi-Takizawa T, Shimizu M, Kume T, Yamazaki H.
    Drug Metab Pharmacokinet; 2015 Feb; 30(1):64-9. PubMed ID: 25760531
    [Abstract] [Full Text] [Related]

  • 9. Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor.
    Kim YW, Kim YK, Kim DK, Sheen YY.
    Xenobiotica; 2008 May; 38(5):451-64. PubMed ID: 18421620
    [Abstract] [Full Text] [Related]

  • 10. Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.
    Rooseboom M, Commandeur JN, Floor GC, Rettie AE, Vermeulen NP.
    Chem Res Toxicol; 2001 Jan; 14(1):127-34. PubMed ID: 11170516
    [Abstract] [Full Text] [Related]

  • 11. Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.
    Blake BL, Rose RL, Mailman RB, Levi PE, Hodgson E.
    Xenobiotica; 1995 Apr; 25(4):377-93. PubMed ID: 7645304
    [Abstract] [Full Text] [Related]

  • 12. Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450.
    Chung WG, Park CS, Roh HK, Lee WK, Cha YN.
    Jpn J Pharmacol; 2000 Oct; 84(2):213-20. PubMed ID: 11128045
    [Abstract] [Full Text] [Related]

  • 13. Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.
    Dalmadi B, Leibinger J, Szeberényi S, Borbás T, Farkas S, Szombathelyi Z, Tihanyi K.
    Drug Metab Dispos; 2003 May; 31(5):631-6. PubMed ID: 12695352
    [Abstract] [Full Text] [Related]

  • 14. A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes.
    Grothusen A, Hardt J, Bräutigam L, Lang D, Böcker R.
    Arch Toxicol; 1996 May; 71(1-2):64-71. PubMed ID: 9010587
    [Abstract] [Full Text] [Related]

  • 15. Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate.
    Madan A, Parkinson A, Faiman MD.
    Biochem Pharmacol; 1993 Dec 14; 46(12):2291-7. PubMed ID: 8274163
    [Abstract] [Full Text] [Related]

  • 16. Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver.
    Wiśniewska A, Chrapkowska A, Kot-Wasik A, Konopa J, Mazerska Z.
    Acta Biochim Pol; 2007 Dec 14; 54(4):831-8. PubMed ID: 18084652
    [Abstract] [Full Text] [Related]

  • 17. Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3, and FMO5 expressed in Escherichia coli.
    Rettie AE, Lawton MP, Sadeque AJ, Meier GP, Philpot RM.
    Arch Biochem Biophys; 1994 Jun 14; 311(2):369-77. PubMed ID: 8203899
    [Abstract] [Full Text] [Related]

  • 18. Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes.
    Shiraga T, Kaneko H, Iwasaki K, Tozuka Z, Suzuki A, Hata T.
    Xenobiotica; 1999 Mar 14; 29(3):217-29. PubMed ID: 10219963
    [Abstract] [Full Text] [Related]

  • 19. Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members.
    Stearns RA, Chakravarty PK, Chen R, Chiu SH.
    Drug Metab Dispos; 1995 Feb 14; 23(2):207-15. PubMed ID: 7736913
    [Abstract] [Full Text] [Related]

  • 20. Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
    Zhang WV, D'Esposito F, Edwards RJ, Ramzan I, Murray M.
    Drug Metab Dispos; 2008 Dec 14; 36(12):2547-55. PubMed ID: 18809730
    [Abstract] [Full Text] [Related]

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