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Journal Abstract Search

454 related items for PubMed ID: 21557999

  • 1. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells.
    Yang L, Wu D, Wang X, Cederbaum AI.
    Free Radic Biol Med; 2011 Jul 01; 51(1):185-96. PubMed ID: 21557999
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.
    Wu D, Cederbaum AI.
    Redox Biol; 2013 Jul 01; 1(1):552-65. PubMed ID: 24273738
    [Abstract] [Full Text] [Related]

  • 3. Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo.
    Wang X, Wu D, Yang L, Gan L, Cederbaum AI.
    Free Radic Biol Med; 2013 Oct 01; 63():175-86. PubMed ID: 23669278
    [Abstract] [Full Text] [Related]

  • 4. Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1.
    Zhuge J, Cederbaum AI.
    Free Radic Biol Med; 2006 Jan 01; 40(1):63-74. PubMed ID: 16337880
    [Abstract] [Full Text] [Related]

  • 5. Nrf2 and antioxidant defense against CYP2E1 toxicity.
    Cederbaum A.
    Expert Opin Drug Metab Toxicol; 2009 Oct 01; 5(10):1223-44. PubMed ID: 19671018
    [Abstract] [Full Text] [Related]

  • 6. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway.
    Gong P, Cederbaum AI, Nieto N.
    J Biol Chem; 2003 Aug 08; 278(32):29693-700. PubMed ID: 12777398
    [Abstract] [Full Text] [Related]

  • 7. Nrf2 and antioxidant defense against CYP2E1 toxicity.
    Cederbaum AI.
    Subcell Biochem; 2013 Aug 08; 67():105-30. PubMed ID: 23400918
    [Abstract] [Full Text] [Related]

  • 8. The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin.
    Lu Y, Cederbaum A.
    Free Radic Biol Med; 2007 Oct 01; 43(7):1061-75. PubMed ID: 17761302
    [Abstract] [Full Text] [Related]

  • 9. Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-kappaB DNA binding activity.
    Wu D, Cederbaum A.
    Mol Pharmacol; 2004 Sep 01; 66(3):749-60. PubMed ID: 15322268
    [Abstract] [Full Text] [Related]

  • 10. Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity.
    Pérez MJ, Cederbaum AI.
    Free Radic Biol Med; 2003 Feb 15; 34(4):443-55. PubMed ID: 12566070
    [Abstract] [Full Text] [Related]

  • 11. Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1.
    Caro AA, Thompson S, Tackett J.
    Cell Biol Toxicol; 2011 Dec 15; 27(6):439-53. PubMed ID: 21850523
    [Abstract] [Full Text] [Related]

  • 12. Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury.
    Wu D, Cederbaum A.
    Free Radic Biol Med; 2010 Aug 01; 49(3):348-60. PubMed ID: 20438834
    [Abstract] [Full Text] [Related]

  • 13. Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1.
    Dey A, Kessova IG, Cederbaum AI.
    Arch Biochem Biophys; 2006 Mar 15; 447(2):155-66. PubMed ID: 16497268
    [Abstract] [Full Text] [Related]

  • 14. Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.
    Marí M, Bai J, Cederbaum AI.
    J Pharmacol Exp Ther; 2002 Apr 15; 301(1):111-8. PubMed ID: 11907164
    [Abstract] [Full Text] [Related]

  • 15. Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury.
    Cederbaum AI, Lu Y, Wang X, Wu D.
    Adv Exp Med Biol; 2015 Apr 15; 815():145-72. PubMed ID: 25427906
    [Abstract] [Full Text] [Related]

  • 16. The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity.
    Gong P, Cederbaum AI, Nieto N.
    Mol Pharmacol; 2004 Jan 15; 65(1):130-8. PubMed ID: 14722244
    [Abstract] [Full Text] [Related]

  • 17. Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1.
    Wu D, Cederbaum AI.
    Alcohol Clin Exp Res; 2001 Apr 15; 25(4):619-28. PubMed ID: 11329505
    [Abstract] [Full Text] [Related]

  • 18. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1.
    Gong P, Cederbaum AI.
    Hepatology; 2006 Jan 15; 43(1):144-53. PubMed ID: 16374848
    [Abstract] [Full Text] [Related]

  • 19. Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity.
    Gong P, Cederbaum AI, Nieto N.
    Free Radic Biol Med; 2004 Feb 01; 36(3):307-18. PubMed ID: 15036350
    [Abstract] [Full Text] [Related]

  • 20. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.
    Wen F, Abdalla MY, Aloman C, Xiang J, Ahmad IM, Walewski J, McCormick ML, Brown KE, Branch AD, Spitz DR, Britigan BE, Schmidt WN.
    J Med Virol; 2004 Feb 01; 72(2):230-40. PubMed ID: 14695664
    [Abstract] [Full Text] [Related]

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