These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

137 related items for PubMed ID: 21568887

  • 1. From structure--based to knowledge--based drug design through x-ray protein crystallography: sketching glycogen phosphorylase binding sites.
    Chrysina ED, Chajistamatiou A, Chegkazi M.
    Curr Med Chem; 2011; 18(17):2620-9. PubMed ID: 21568887
    [Abstract] [Full Text] [Related]

  • 2. Advances in glycogen phosphorylase inhibitor design.
    Oikonomakos NG, Somsák L.
    Curr Opin Investig Drugs; 2008 Apr; 9(4):379-95. PubMed ID: 18393105
    [Abstract] [Full Text] [Related]

  • 3. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
    Tsitsanou KE, Hayes JM, Keramioti M, Mamais M, Oikonomakos NG, Kato A, Leonidas DD, Zographos SE.
    Food Chem Toxicol; 2013 Nov; 61():14-27. PubMed ID: 23279842
    [Abstract] [Full Text] [Related]

  • 4. 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
    Tsirkone VG, Tsoukala E, Lamprakis C, Manta S, Hayes JM, Skamnaki VT, Drakou C, Zographos SE, Komiotis D, Leonidas DD.
    Bioorg Med Chem; 2010 May 15; 18(10):3413-25. PubMed ID: 20430629
    [Abstract] [Full Text] [Related]

  • 5. High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors.
    Fischer T, Koulas SM, Tsagkarakou AS, Kyriakis E, Stravodimos GA, Skamnaki VT, Liggri PGV, Zographos SE, Riedl R, Leonidas DD.
    Molecules; 2019 Apr 03; 24(7):. PubMed ID: 30987252
    [Abstract] [Full Text] [Related]

  • 6. A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site.
    Mamais M, Degli Esposti A, Kouloumoundra V, Gustavsson T, Monti F, Venturini A, Chrysina ED, Markovitsi D, Gimisis T.
    Chemistry; 2017 Jul 03; 23(37):8800-8805. PubMed ID: 28493496
    [Abstract] [Full Text] [Related]

  • 7. Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
    Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL.
    Chem Biol; 2002 Aug 03; 9(8):915-24. PubMed ID: 12204691
    [Abstract] [Full Text] [Related]

  • 8. New inhibitors of glycogen phosphorylase as potential antidiabetic agents.
    Somsák L, Czifrák K, Tóth M, Bokor E, Chrysina ED, Alexacou KM, Hayes JM, Tiraidis C, Lazoura E, Leonidas DD, Zographos SE, Oikonomakos NG.
    Curr Med Chem; 2008 Aug 03; 15(28):2933-83. PubMed ID: 19075645
    [Abstract] [Full Text] [Related]

  • 9. Glycogen phosphorylase as a molecular target for type 2 diabetes therapy.
    Oikonomakos NG.
    Curr Protein Pept Sci; 2002 Dec 03; 3(6):561-86. PubMed ID: 12470212
    [Abstract] [Full Text] [Related]

  • 10. A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
    Kun S, Begum J, Kyriakis E, Stamati ECV, Barkas TA, Szennyes E, Bokor É, Szabó KE, Stravodimos GA, Sipos Á, Docsa T, Gergely P, Moffatt C, Patraskaki MS, Kokolaki MC, Gkerdi A, Skamnaki VT, Leonidas DD, Somsák L, Hayes JM.
    Eur J Med Chem; 2018 Mar 10; 147():266-278. PubMed ID: 29453094
    [Abstract] [Full Text] [Related]

  • 11. Computation as a tool for glycogen phosphorylase inhibitor design.
    Hayes JM, Leonidas DD.
    Mini Rev Med Chem; 2010 Oct 10; 10(12):1156-74. PubMed ID: 20716053
    [Abstract] [Full Text] [Related]

  • 12. The prototype of glycogen phosphorylase.
    Chrysina ED.
    Mini Rev Med Chem; 2010 Oct 10; 10(12):1093-101. PubMed ID: 20716055
    [Abstract] [Full Text] [Related]

  • 13. Glycogen phosphorylase inhibitors: a free energy perturbation analysis of glucopyranose spirohydantoin analogues.
    Archontis G, Watson KA, Xie Q, Andreou G, Chrysina ED, Zographos SE, Oikonomakos NG, Karplus M.
    Proteins; 2005 Dec 01; 61(4):984-98. PubMed ID: 16245298
    [Abstract] [Full Text] [Related]

  • 14. The structure of brain glycogen phosphorylase-from allosteric regulation mechanisms to clinical perspectives.
    Mathieu C, Dupret JM, Rodrigues Lima F.
    FEBS J; 2017 Feb 01; 284(4):546-554. PubMed ID: 27782369
    [Abstract] [Full Text] [Related]

  • 15. Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
    Chetter BA, Kyriakis E, Barr D, Karra AG, Katsidou E, Koulas SM, Skamnaki VT, Snape TJ, Psarra AG, Leonidas DD, Hayes JM.
    Bioorg Chem; 2020 Sep 01; 102():104003. PubMed ID: 32771768
    [Abstract] [Full Text] [Related]

  • 16. Recent advances in the allosteric inhibition of glycogen phosphorylase.
    Loughlin WA.
    Mini Rev Med Chem; 2010 Oct 01; 10(12):1139-55. PubMed ID: 20716052
    [Abstract] [Full Text] [Related]

  • 17. Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
    Kyriakis E, Solovou TGA, Kun S, Czifrák K, Szőcs B, Juhász L, Bokor É, Stravodimos GA, Kantsadi AL, Chatzileontiadou DSM, Skamnaki VT, Somsák L, Leonidas DD.
    Bioorg Chem; 2018 Apr 01; 77():485-493. PubMed ID: 29454281
    [Abstract] [Full Text] [Related]

  • 18. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
    Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Zhang L, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG.
    J Med Chem; 2008 Jun 26; 51(12):3540-54. PubMed ID: 18517260
    [Abstract] [Full Text] [Related]

  • 19. A new allosteric site in glycogen phosphorylase b as a target for drug interactions.
    Oikonomakos NG, Skamnaki VT, Tsitsanou KE, Gavalas NG, Johnson LN.
    Structure; 2000 Jun 15; 8(6):575-84. PubMed ID: 10873856
    [Abstract] [Full Text] [Related]

  • 20. An Improved Comparative Docking Approach for Developing Specific Glycogen Phosphorylase Inhibitors Using Pentacyclic Triterpenes.
    Konkimalla VB.
    Curr Top Med Chem; 2017 Jun 15; 17(14):1640-1645. PubMed ID: 27823565
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 7.