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350 related items for PubMed ID: 21586282

  • 1. Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice.
    Winzell MS, Coghlan M, Leighton B, Frangioudakis G, Smith DM, Storlien LH, Ahrén B.
    Eur J Pharmacol; 2011 Aug 01; 663(1-3):80-6. PubMed ID: 21586282
    [Abstract] [Full Text] [Related]

  • 2. Upregulation of β-cell genes and improved function in rodent islets following chronic glucokinase activation.
    Gill D, Brocklehurst KJ, Brown HW, Smith DM.
    J Mol Endocrinol; 2011 Aug 01; 47(1):59-67. PubMed ID: 21571864
    [Abstract] [Full Text] [Related]

  • 3. Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.
    Gorman T, Hope DC, Brownlie R, Yu A, Gill D, Löfvenmark J, Wedin M, Mayers RM, Snaith MR, Smith DM.
    Diabetes Obes Metab; 2008 Sep 01; 10(10):885-97. PubMed ID: 18034843
    [Abstract] [Full Text] [Related]

  • 4. TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models.
    Tsumura Y, Tsushima Y, Tamura A, Hasebe M, Kanou M, Kato H, Kobayashi T.
    PLoS One; 2017 Sep 01; 12(2):e0172252. PubMed ID: 28207836
    [Abstract] [Full Text] [Related]

  • 5. Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
    Sreenan SK, Cockburn BN, Baldwin AC, Ostrega DM, Levisetti M, Grupe A, Bell GI, Stewart TA, Roe MW, Polonsky KS.
    Diabetes; 1998 Dec 01; 47(12):1881-8. PubMed ID: 9836519
    [Abstract] [Full Text] [Related]

  • 6. Allosteric activators of glucokinase: potential role in diabetes therapy.
    Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.
    Science; 2003 Jul 18; 301(5631):370-3. PubMed ID: 12869762
    [Abstract] [Full Text] [Related]

  • 7. An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.
    Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.
    J Biol Chem; 2006 Dec 08; 281(49):37668-74. PubMed ID: 17028192
    [Abstract] [Full Text] [Related]

  • 8. A novel glucokinase activator modulates pancreatic islet and hepatocyte function.
    Efanov AM, Barrett DG, Brenner MB, Briggs SL, Delaunois A, Durbin JD, Giese U, Guo H, Radloff M, Gil GS, Sewing S, Wang Y, Weichert A, Zaliani A, Gromada J.
    Endocrinology; 2005 Sep 08; 146(9):3696-701. PubMed ID: 15919746
    [Abstract] [Full Text] [Related]

  • 9. Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.
    Winzell MS, Brand CL, Wierup N, Sidelmann UG, Sundler F, Nishimura E, Ahrén B.
    Diabetologia; 2007 Jul 08; 50(7):1453-62. PubMed ID: 17479245
    [Abstract] [Full Text] [Related]

  • 10. Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration.
    Roma LP, Duprez J, Jonas JC.
    Am J Physiol Endocrinol Metab; 2015 Oct 01; 309(7):E632-9. PubMed ID: 26264555
    [Abstract] [Full Text] [Related]

  • 11. Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.
    Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V.
    Diabetes; 2002 Mar 01; 51(3):662-8. PubMed ID: 11872664
    [Abstract] [Full Text] [Related]

  • 12. The effects of high-fat diet on exercise-induced changes in metabolic parameters in Zucker fa/fa rats.
    Kibenge MT, Chan CB.
    Metabolism; 2002 Jun 01; 51(6):708-15. PubMed ID: 12037723
    [Abstract] [Full Text] [Related]

  • 13. MiR-206 is expressed in pancreatic islets and regulates glucokinase activity.
    Vinod M, Patankar JV, Sachdev V, Frank S, Graier WF, Kratky D, Kostner GM.
    Am J Physiol Endocrinol Metab; 2016 Jul 01; 311(1):E175-E185. PubMed ID: 27221121
    [Abstract] [Full Text] [Related]

  • 14. Characterization of a novel glucokinase activator in rat and mouse models.
    Lu M, Li P, Bandyopadhyay G, Lagakos W, Dewolf WE, Alford T, Chicarelli MJ, Williams L, Anderson DA, Baer BR, McVean M, Conn M, Véniant MM, Coward P.
    PLoS One; 2014 Jul 01; 9(2):e88431. PubMed ID: 24533087
    [Abstract] [Full Text] [Related]

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  • 16. Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960.
    Laurent D, Yerby B, Zhang B, Chen XH, Gounarides J, Zhang J, Gao J, Bebernitz G, Duttaroy A.
    Eur J Pharmacol; 2013 Sep 05; 715(1-3):89-95. PubMed ID: 23816435
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  • 18. Effects of high-carbohydrate or high-fat diet on carbohydrate metabolism and insulin secretion in the normal rat.
    Ramirez R, López JM, Bedoya FJ, Goberna R.
    Diabetes Res; 1990 Dec 05; 15(4):179-83. PubMed ID: 2132406
    [Abstract] [Full Text] [Related]

  • 19. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs.
    Eiki J, Nagata Y, Futamura M, Sasaki-Yamamoto K, Iino T, Nishimura T, Chiba M, Ohyama S, Yoshida-Yoshimioto R, Fujii K, Hosaka H, Goto-Shimazaki H, Kadotani A, Ohe T, Lin S, Langdon RB, Berger JP.
    Mol Pharmacol; 2011 Dec 05; 80(6):1156-65. PubMed ID: 21937665
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