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206 related items for PubMed ID: 21591605

  • 21. Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening.
    Kovac A, Konc J, Vehar B, Bostock JM, Chopra I, Janezic D, Gobec S.
    J Med Chem; 2008 Dec 11; 51(23):7442-8. PubMed ID: 19053785
    [Abstract] [Full Text] [Related]

  • 22. Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.
    Nie Z, Perretta C, Lu J, Su Y, Margosiak S, Gajiwala KS, Cortez J, Nikulin V, Yager KM, Appelt K, Chu S.
    J Med Chem; 2005 Mar 10; 48(5):1596-609. PubMed ID: 15743201
    [Abstract] [Full Text] [Related]

  • 23. Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.
    Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S.
    Eur J Med Chem; 2014 Feb 12; 73():83-96. PubMed ID: 24384549
    [Abstract] [Full Text] [Related]

  • 24. NMR and molecular dynamics study of the binding mode of naphthalene-N-sulfonyl-D-glutamic acid derivatives: novel MurD ligase inhibitors.
    Simcic M, Hodoscek M, Humljan J, Kristan K, Urleb U, Kocjan D, Grdadolnik SG.
    J Med Chem; 2009 May 14; 52(9):2899-908. PubMed ID: 19358612
    [Abstract] [Full Text] [Related]

  • 25. Molecular dynamics simulation and linear interaction energy study of D-Glu-based inhibitors of the MurD ligase.
    Perdih A, Wolber G, Solmajer T.
    J Comput Aided Mol Des; 2013 Aug 14; 27(8):723-38. PubMed ID: 23990043
    [Abstract] [Full Text] [Related]

  • 26. The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors.
    Simčič M, Sosič I, Hodošček M, Barreteau H, Blanot D, Gobec S, Grdadolnik SG.
    PLoS One; 2012 Aug 14; 7(12):e52817. PubMed ID: 23285193
    [Abstract] [Full Text] [Related]

  • 27. Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors.
    Lv PC, Wang KR, Yang Y, Mao WJ, Chen J, Xiong J, Zhu HL.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6750-4. PubMed ID: 19836235
    [Abstract] [Full Text] [Related]

  • 28. Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.
    Bertrand JA, Auger G, Martin L, Fanchon E, Blanot D, Le Beller D, van Heijenoort J, Dideberg O.
    J Mol Biol; 1999 Jun 11; 289(3):579-90. PubMed ID: 10356330
    [Abstract] [Full Text] [Related]

  • 29. Inhibitor design strategy based on an enzyme structural flexibility: a case of bacterial MurD ligase.
    Perdih A, Hrast M, Barreteau H, Gobec S, Wolber G, Solmajer T.
    J Chem Inf Model; 2014 May 27; 54(5):1451-66. PubMed ID: 24724969
    [Abstract] [Full Text] [Related]

  • 30. Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF.
    Sova M, Kovac A, Turk S, Hrast M, Blanot D, Gobec S.
    Bioorg Chem; 2009 Dec 27; 37(6):217-22. PubMed ID: 19804894
    [Abstract] [Full Text] [Related]

  • 31. Peptide inhibitors of MurD and MurE, essential enzymes of bacterial cell wall biosynthesis.
    Bratkovic T, Lunder M, Urleb U, Strukelj B.
    J Basic Microbiol; 2008 Jun 27; 48(3):202-6. PubMed ID: 18506905
    [Abstract] [Full Text] [Related]

  • 32. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
    Wang T, Duncan L, Gu W, O'Dowd H, Wei Y, Perola E, Parsons J, Gross CH, Moody CS, Arends SJ, Charifson PS.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3699-703. PubMed ID: 22560470
    [Abstract] [Full Text] [Related]

  • 33. Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-4-amino-4-methylpiperidin-1-yl) fluoroquinolone derivatives.
    Wang JX, Zhang YB, Liu ML, Wang B, Chai Y, Li SJ, Guo HY.
    Eur J Med Chem; 2011 Jun 01; 46(6):2421-6. PubMed ID: 21481984
    [Abstract] [Full Text] [Related]

  • 34. A novel 2-oxoindolinylidene inhibitor of bacterial MurD ligase: Enzyme kinetics, protein-inhibitor binding by NMR and a molecular dynamics study.
    Simčič M, Pureber K, Kristan K, Urleb U, Kocjan D, Grdadolnik SG.
    Eur J Med Chem; 2014 Aug 18; 83():92-101. PubMed ID: 24952377
    [Abstract] [Full Text] [Related]

  • 35. Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S.
    Lee DL, Hodges RS.
    Biopolymers; 2003 Aug 18; 71(1):28-48. PubMed ID: 12712499
    [Abstract] [Full Text] [Related]

  • 36. Design and synthesis of potent Gram-negative specific LpxC inhibitors.
    Mansoor UF, Vitharana D, Reddy PA, Daubaras DL, McNicholas P, Orth P, Black T, Siddiqui MA.
    Bioorg Med Chem Lett; 2011 Feb 15; 21(4):1155-61. PubMed ID: 21273067
    [Abstract] [Full Text] [Related]

  • 37. Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
    Kawatkar SP, Keating TA, Olivier NB, Breen JN, Green OM, Guler SY, Hentemann MF, Loch JT, McKenzie AR, Newman JV, Otterson LG, Martínez-Botella G.
    J Med Chem; 2014 Jun 12; 57(11):4584-97. PubMed ID: 24828090
    [Abstract] [Full Text] [Related]

  • 38. Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF).
    Perdih A, Hrast M, Barreteau H, Gobec S, Wolber G, Solmajer T.
    Bioorg Med Chem; 2014 Aug 01; 22(15):4124-34. PubMed ID: 24953950
    [Abstract] [Full Text] [Related]

  • 39. Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.
    Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4368-72. PubMed ID: 18614367
    [Abstract] [Full Text] [Related]

  • 40. Combining molecular docking and molecular dynamics studies for modelling Staphylococcus aureus MurD inhibitory activity.
    Azam MA, Jupudi S, Saha N, Paul RK.
    SAR QSAR Environ Res; 2019 Jan 01; 30(1):1-20. PubMed ID: 30406684
    [Abstract] [Full Text] [Related]

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