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Journal Abstract Search

217 related items for PubMed ID: 21620961

  • 1. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
    Lim KG, Sun C, Bittman R, Pyne NJ, Pyne S.
    Cell Signal; 2011 Oct; 23(10):1590-5. PubMed ID: 21620961
    [Abstract] [Full Text] [Related]

  • 2. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
    Lim KG, Tonelli F, Li Z, Lu X, Bittman R, Pyne S, Pyne NJ.
    J Biol Chem; 2011 May 27; 286(21):18633-40. PubMed ID: 21464128
    [Abstract] [Full Text] [Related]

  • 3. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
    Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ.
    Cell Signal; 2010 Oct 27; 22(10):1536-42. PubMed ID: 20570726
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  • 7. Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.
    Adams DR, Pyne S, Pyne NJ.
    Cell Signal; 2020 Dec 27; 76():109806. PubMed ID: 33035646
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  • 9. Targeting sphingosine-1-phosphate in hematologic malignancies.
    Stevenson CE, Takabe K, Nagahashi M, Milstien S, Spiegel S.
    Anticancer Agents Med Chem; 2011 Nov 27; 11(9):794-8. PubMed ID: 21707492
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  • 10. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
    Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V.
    J Biol Chem; 2009 Feb 27; 284(9):5467-77. PubMed ID: 19119142
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  • 11. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
    Ohotski J, Rosen H, Bittman R, Pyne S, Pyne NJ.
    Cell Signal; 2014 May 27; 26(5):1040-7. PubMed ID: 24486401
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  • 12. FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.
    Vessey DA, Li L, Imhof I, Honbo N, Karliner JS.
    Med Sci Monit Basic Res; 2013 Apr 09; 19():126-32. PubMed ID: 23567658
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  • 13. Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
    Evangelisti C, Evangelisti C, Teti G, Chiarini F, Falconi M, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Beak DJ, Bittman R, Pyne S, Pyne NJ, Martelli AM.
    Oncotarget; 2014 Sep 15; 5(17):7886-901. PubMed ID: 25226616
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  • 14. Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.
    Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H.
    Am J Physiol Cell Physiol; 2009 Oct 15; 297(4):C945-54. PubMed ID: 19657053
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  • 15. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
    Tonelli F, Alossaimi M, Williamson L, Tate RJ, Watson DG, Chan E, Bittman R, Pyne NJ, Pyne S.
    Br J Pharmacol; 2013 Mar 15; 168(6):1497-505. PubMed ID: 23113536
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  • 16. "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
    Takabe K, Paugh SW, Milstien S, Spiegel S.
    Pharmacol Rev; 2008 Jun 15; 60(2):181-95. PubMed ID: 18552276
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  • 17. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
    Watson DG, Tonelli F, Alossaimi M, Williamson L, Chan E, Gorshkova I, Berdyshev E, Bittman R, Pyne NJ, Pyne S.
    Cell Signal; 2013 Apr 15; 25(4):1011-7. PubMed ID: 23314175
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  • 18. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
    Brinkmann V.
    Br J Pharmacol; 2009 Nov 15; 158(5):1173-82. PubMed ID: 19814729
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  • 19. Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.
    Ter Braak M, Claas RF, Hegen B, Labocha S, Ferreirós N, Pfeilschifter J, Huwiler A, van Echten-Deckert G, Meyer Zu Heringdorf D.
    Biochem Pharmacol; 2011 Mar 01; 81(5):617-25. PubMed ID: 21163254
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  • 20. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
    Zemann B, Kinzel B, Müller M, Reuschel R, Mechtcheriakova D, Urtz N, Bornancin F, Baumruker T, Billich A.
    Blood; 2006 Feb 15; 107(4):1454-8. PubMed ID: 16223773
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