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Journal Abstract Search

278 related items for PubMed ID: 21624052

  • 1. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    FEBS J; 2011 Dec; 278(23):4506-15. PubMed ID: 21624052
    [Abstract] [Full Text] [Related]

  • 2. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
    Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
    Biochem J; 2010 Oct 15; 431(2):207-16. PubMed ID: 20704566
    [Abstract] [Full Text] [Related]

  • 3. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.
    Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.
    Toxicon; 2013 Dec 01; 75():108-21. PubMed ID: 23817019
    [Abstract] [Full Text] [Related]

  • 4. The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    Mol Microbiol; 2004 Feb 01; 51(3):631-43. PubMed ID: 14731268
    [Abstract] [Full Text] [Related]

  • 5. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.
    Rummel A.
    Curr Top Microbiol Immunol; 2013 Feb 01; 364():61-90. PubMed ID: 23239349
    [Abstract] [Full Text] [Related]

  • 6. Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins.
    Tsukamoto K, Kohda T, Mukamoto M, Takeuchi K, Ihara H, Saito M, Kozaki S.
    J Biol Chem; 2005 Oct 21; 280(42):35164-71. PubMed ID: 16115873
    [Abstract] [Full Text] [Related]

  • 7. Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
    Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC.
    Nature; 2006 Dec 21; 444(7122):1096-100. PubMed ID: 17167418
    [Abstract] [Full Text] [Related]

  • 8. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.
    Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, Beermann S, Karnath T, Bigalke H, Binz T.
    J Neurochem; 2009 Sep 21; 110(6):1942-54. PubMed ID: 19650874
    [Abstract] [Full Text] [Related]

  • 9. Location of the synaptosome-binding regions on botulinum neurotoxin B.
    Dolimbek BZ, Steward LE, Aoki KR, Atassi MZ.
    Biochemistry; 2012 Jan 10; 51(1):316-28. PubMed ID: 22146011
    [Abstract] [Full Text] [Related]

  • 10. The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
    Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.
    Mol Microbiol; 2011 Jul 10; 81(1):143-56. PubMed ID: 21542861
    [Abstract] [Full Text] [Related]

  • 11. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.
    Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.
    Biochemistry; 2013 Jun 04; 52(22):3930-8. PubMed ID: 23647335
    [Abstract] [Full Text] [Related]

  • 12. Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.
    Rummel A, Karnath T, Henke T, Bigalke H, Binz T.
    J Biol Chem; 2004 Jul 16; 279(29):30865-70. PubMed ID: 15123599
    [Abstract] [Full Text] [Related]

  • 13. Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: insight into the ganglioside binding mechanism.
    Nuemket N, Tanaka Y, Tsukamoto K, Tsuji T, Nakamura K, Kozaki S, Yao M, Tanaka I.
    Biochem Biophys Res Commun; 2011 Jul 29; 411(2):433-9. PubMed ID: 21749855
    [Abstract] [Full Text] [Related]

  • 14. Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.
    Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.
    FEBS Lett; 2013 Nov 29; 587(23):3831-6. PubMed ID: 24157364
    [Abstract] [Full Text] [Related]

  • 15. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
    Jin R, Rummel A, Binz T, Brunger AT.
    Nature; 2006 Dec 21; 444(7122):1092-5. PubMed ID: 17167421
    [Abstract] [Full Text] [Related]

  • 16. Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.
    Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
    Proc Natl Acad Sci U S A; 2007 Jan 02; 104(1):359-64. PubMed ID: 17185412
    [Abstract] [Full Text] [Related]

  • 17. Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
    Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT.
    J Biol Chem; 2012 Nov 23; 287(48):40806-16. PubMed ID: 23027864
    [Abstract] [Full Text] [Related]

  • 18. Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding.
    Stenmark P, Dong M, Dupuy J, Chapman ER, Stevens RC.
    J Mol Biol; 2010 Apr 16; 397(5):1287-97. PubMed ID: 20219474
    [Abstract] [Full Text] [Related]

  • 19. Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation.
    Kumaran D, Eswaramoorthy S, Furey W, Navaza J, Sax M, Swaminathan S.
    J Mol Biol; 2009 Feb 13; 386(1):233-45. PubMed ID: 19118561
    [Abstract] [Full Text] [Related]

  • 20. Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity.
    Arndt JW, Chai Q, Christian T, Stevens RC.
    Biochemistry; 2006 Mar 14; 45(10):3255-62. PubMed ID: 16519520
    [Abstract] [Full Text] [Related]

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