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299 related items for PubMed ID: 21656528

  • 1. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.
    Saw CL, Cintrón M, Wu TY, Guo Y, Huang Y, Jeong WS, Kong AN.
    Biopharm Drug Dispos; 2011 Jul; 32(5):289-300. PubMed ID: 21656528
    [Abstract] [Full Text] [Related]

  • 2. Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression.
    Prawan A, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN.
    Pharm Res; 2008 Apr; 25(4):836-44. PubMed ID: 17657593
    [Abstract] [Full Text] [Related]

  • 3. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.
    Bonnesen C, Eggleston IM, Hayes JD.
    Cancer Res; 2001 Aug 15; 61(16):6120-30. PubMed ID: 11507062
    [Abstract] [Full Text] [Related]

  • 4. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
    Jeong WS, Keum YS, Chen C, Jain MR, Shen G, Kim JH, Li W, Kong AN.
    J Biochem Mol Biol; 2005 Mar 31; 38(2):167-76. PubMed ID: 15826493
    [Abstract] [Full Text] [Related]

  • 5. In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.
    Wu TY, Saw CL, Khor TO, Pung D, Boyanapalli SS, Kong AN.
    Mol Carcinog; 2012 Oct 31; 51(10):761-70. PubMed ID: 21837756
    [Abstract] [Full Text] [Related]

  • 6. Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
    García A, Haza AI, Arranz N, Rafter J, Morales P.
    J Appl Toxicol; 2008 Mar 31; 28(2):196-204. PubMed ID: 17582584
    [Abstract] [Full Text] [Related]

  • 7. Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells.
    Krajka-Kuźniak V, Cykowiak M, Szaefer H, Kleszcz R, Baer-Dubowska W.
    Toxicol In Vitro; 2020 Jun 31; 65():104799. PubMed ID: 32070777
    [Abstract] [Full Text] [Related]

  • 8. Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.
    Pappa G, Strathmann J, Löwinger M, Bartsch H, Gerhäuser C.
    Carcinogenesis; 2007 Jul 31; 28(7):1471-7. PubMed ID: 17331956
    [Abstract] [Full Text] [Related]

  • 9. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).
    Keum YS, Owuor ED, Kim BR, Hu R, Kong AN.
    Pharm Res; 2003 Sep 31; 20(9):1351-6. PubMed ID: 14567627
    [Abstract] [Full Text] [Related]

  • 10. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes.
    Kleszczyński K, Ernst IM, Wagner AE, Kruse N, Zillikens D, Rimbach G, Fischer TW.
    Pharmacol Res; 2013 Dec 31; 78():28-40. PubMed ID: 24121007
    [Abstract] [Full Text] [Related]

  • 11. Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.
    Wang H, Khor TO, Yang Q, Huang Y, Wu TY, Saw CL, Lin W, Androulakis IP, Kong AN.
    Mol Pharm; 2012 Oct 01; 9(10):2819-27. PubMed ID: 22931102
    [Abstract] [Full Text] [Related]

  • 12. Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture.
    Wagner AE, Ernst I, Iori R, Desel C, Rimbach G.
    Exp Dermatol; 2010 Feb 01; 19(2):137-44. PubMed ID: 19558496
    [Abstract] [Full Text] [Related]

  • 13. Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo.
    Cykowiak M, Krajka-Kuźniak V, Kleszcz R, Kucińska M, Szaefer H, Piotrowska-Kempisty H, Plewiński A, Murias M, Baer-Dubowska W.
    Nutrients; 2021 Aug 28; 13(9):. PubMed ID: 34578877
    [Abstract] [Full Text] [Related]

  • 14. 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts.
    Ernst IM, Schuemann C, Wagner AE, Rimbach G.
    Free Radic Res; 2011 Aug 28; 45(8):941-9. PubMed ID: 21615272
    [Abstract] [Full Text] [Related]

  • 15. Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers.
    Soundararajan P, Kim JS.
    Molecules; 2018 Nov 15; 23(11):. PubMed ID: 30445746
    [Abstract] [Full Text] [Related]

  • 16. The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression.
    Krajka-Kuźniak V, Paluszczak J, Szaefer H, Baer-Dubowska W.
    J Physiol Biochem; 2015 Jun 15; 71(2):227-38. PubMed ID: 25800511
    [Abstract] [Full Text] [Related]

  • 17. Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.
    Gross-Steinmeyer K, Stapleton PL, Liu F, Tracy JH, Bammler TK, Quigley SD, Farin FM, Buhler DR, Safe SH, Strom SC, Eaton DL.
    Xenobiotica; 2004 Jul 15; 34(7):619-32. PubMed ID: 15672752
    [Abstract] [Full Text] [Related]

  • 18. Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.
    Krajka-Kuźniak V, Szaefer H, Bartoszek A, Baer-Dubowska W.
    Br J Nutr; 2011 Mar 15; 105(6):816-26. PubMed ID: 21092375
    [Abstract] [Full Text] [Related]

  • 19. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
    Xu C, Yuan X, Pan Z, Shen G, Kim JH, Yu S, Khor TO, Li W, Ma J, Kong AN.
    Mol Cancer Ther; 2006 Aug 15; 5(8):1918-26. PubMed ID: 16928811
    [Abstract] [Full Text] [Related]

  • 20. Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.
    Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishnan A, Lin W, Reddy B, Chan JY, Kong AN.
    Life Sci; 2006 Oct 12; 79(20):1944-55. PubMed ID: 16828809
    [Abstract] [Full Text] [Related]

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