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Journal Abstract Search

183 related items for PubMed ID: 21667953

  • 1. Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
    Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC.
    Chem Res Toxicol; 2011 Jul 18; 24(7):1012-30. PubMed ID: 21667953
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  • 2. Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.
    Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K.
    Drug Metab Dispos; 2007 Jun 18; 35(6):848-58. PubMed ID: 17344339
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  • 3. 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A₁ and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.
    Squarcialupi L, Colotta V, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Borea PA, Porta N, Ciancetta A, Moro S.
    Eur J Med Chem; 2014 Sep 12; 84():614-27. PubMed ID: 25063944
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  • 5. In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
    Ross MK, Pegram RA.
    Toxicol Appl Pharmacol; 2004 Mar 01; 195(2):166-81. PubMed ID: 14998683
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  • 10. Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists.
    Robinson SJ, Petzer JP, Rousseau AL, Terre'Blanche G, Petzer A, Lourens ACU.
    Bioorg Med Chem Lett; 2016 Feb 01; 26(3):734-738. PubMed ID: 26776359
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  • 12. Genotoxicity of 1,3-butadiene and its epoxy intermediates.
    Walker VE, Walker DM, Meng Q, McDonald JD, Scott BR, Seilkop SK, Claffey DJ, Upton PB, Powley MW, Swenberg JA, Henderson RF, Health Review Committee.
    Res Rep Health Eff Inst; 2009 Aug 01; (144):3-79. PubMed ID: 20017413
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  • 13. Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives.
    Matos MJ, Gaspar A, Kachler S, Klotz KN, Borges F, Santana L, Uriarte E.
    J Pharm Pharmacol; 2013 Jan 01; 65(1):30-4. PubMed ID: 23215685
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  • 14. In vitro bioactivation of a selective estrogen receptor modulator (2S,3R)-(+)-3-(3-hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol (I) in liver microsomes: formation of adenine adducts.
    Li Y, Doss GA, Li Y, Chen Q, Tang W, Zhang Z.
    Chem Res Toxicol; 2012 Nov 19; 25(11):2368-77. PubMed ID: 22998117
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  • 15. 2-Aminopyrimidines as dual adenosine A1/A2A antagonists.
    Robinson SJ, Petzer JP, Terre'Blanche G, Petzer A, van der Walt MM, Bergh JJ, Lourens AC.
    Eur J Med Chem; 2015 Nov 02; 104():177-88. PubMed ID: 26462195
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  • 16. 5-Substituted 2-benzylidene-1-tetralone analogues as A1 and/or A2A antagonists for the potential treatment of neurological conditions.
    Janse van Rensburg HD, Terre'Blanche G, van der Walt MM, Legoabe LJ.
    Bioorg Chem; 2017 Oct 02; 74():251-259. PubMed ID: 28881253
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  • 19. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y, Choquette D, Liu J, Colletti AE, Hollis LS, Lin MH, Zhao Z.
    Chem Res Toxicol; 2010 Nov 15; 23(11):1743-52. PubMed ID: 20825217
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  • 20. Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility.
    Cosimelli B, Taliani S, Greco G, Novellino E, Sala A, Severi E, Da Settimo F, La Motta C, Pugliesi I, Antonioli L, Fornai M, Colucci R, Blandizzi C, Daniele S, Trincavelli ML, Martini C.
    ChemMedChem; 2011 Oct 04; 6(10):1909-18. PubMed ID: 21796795
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