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Journal Abstract Search

223 related items for PubMed ID: 21682254

  • 21. Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.
    Onodera H, Kaneko M, Takahashi Y, Uochi Y, Funahashi J, Nakashima T, Soga S, Suzuki M, Ikeda S, Yamashita Y, Rahayu ES, Kanda Y, Ichimura M.
    Bioorg Med Chem Lett; 2008 Mar 01; 18(5):1588-91. PubMed ID: 18243703
    [Abstract] [Full Text] [Related]

  • 22. 7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997.
    Ni S, Wu L, Wang H, Wang Y, He W, Li Y, Jia C, Li S, Wang Y.
    J Antibiot (Tokyo); 2010 Oct 01; 63(10):623-5. PubMed ID: 20683449
    [No Abstract] [Full Text] [Related]

  • 23. The complete genome sequence of Streptomyces autolyticus CGMCC 0516, the producer of geldanamycin, autolytimycin, reblastatin and elaiophylin.
    Yin M, Jiang M, Ren Z, Dong Y, Lu T.
    J Biotechnol; 2017 Jun 20; 252():27-31. PubMed ID: 28472671
    [Abstract] [Full Text] [Related]

  • 24. Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety.
    Lee D, Lee K, Cai XF, Dat NT, Boovanahalli SK, Lee M, Shin JC, Kim W, Jeong JK, Lee JS, Lee CH, Lee JH, Hong YS, Lee JJ.
    Chembiochem; 2006 Feb 20; 7(2):246-8. PubMed ID: 16381049
    [No Abstract] [Full Text] [Related]

  • 25. Inactivation of putative PKS genes can double geldanamycin yield in Streptomyces hygroscopicus 17997.
    Li YH, Li M, He WQ, Wang YG, Shao RG.
    Genet Mol Res; 2013 Jun 21; 12(2):2076-85. PubMed ID: 23913387
    [Abstract] [Full Text] [Related]

  • 26. Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.
    Patel K, Piagentini M, Rascher A, Tian ZQ, Buchanan GO, Regentin R, Hu Z, Hutchinson CR, McDaniel R.
    Chem Biol; 2004 Dec 21; 11(12):1625-33. PubMed ID: 15610846
    [Abstract] [Full Text] [Related]

  • 27. Molecular characterization of macbecin as an Hsp90 inhibitor.
    Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.
    J Med Chem; 2008 May 08; 51(9):2853-7. PubMed ID: 18357975
    [Abstract] [Full Text] [Related]

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  • 29. Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.
    Kim W, Lee JS, Lee D, Cai XF, Shin JC, Lee K, Lee CH, Ryu S, Paik SG, Lee JJ, Hong YS.
    Chembiochem; 2007 Sep 03; 8(13):1491-4. PubMed ID: 17661303
    [No Abstract] [Full Text] [Related]

  • 30. Lipophilic prodrugs of Hsp90 inhibitor geldanamycin for nanoencapsulation in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles.
    Forrest ML, Zhao A, Won CY, Malick AW, Kwon GS.
    J Control Release; 2006 Nov 28; 116(2):139-49. PubMed ID: 16926059
    [Abstract] [Full Text] [Related]

  • 31. The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.
    Eichner S, Knobloch T, Floss HG, Fohrer J, Harmrolfs K, Hermane J, Schulz A, Sasse F, Spiteller P, Taft F, Kirschning A.
    Angew Chem Int Ed Engl; 2012 Jan 16; 51(3):752-7. PubMed ID: 22135226
    [No Abstract] [Full Text] [Related]

  • 32. New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.
    Hermane J, Bułyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A.
    Chembiochem; 2015 Jan 19; 16(2):302-11. PubMed ID: 25572106
    [Abstract] [Full Text] [Related]

  • 33. Streptomyces autolyticus JX-47 large-insert bacterial artificial chromosome library construction and identification of clones covering geldanamycin biosynthesis gene cluster.
    Dai S, Ouyang Y, Wang G, Li X.
    Curr Microbiol; 2011 Jul 19; 63(1):68-74. PubMed ID: 21544574
    [Abstract] [Full Text] [Related]

  • 34. Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.
    McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.
    Org Biomol Chem; 2007 Feb 07; 5(3):531-46. PubMed ID: 17252137
    [Abstract] [Full Text] [Related]

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  • 36. Functional characterization of KanP, a methyltransferase from the kanamycin biosynthetic gene cluster of Streptomyces kanamyceticus.
    Nepal KK, Yoo JC, Sohng JK.
    Microbiol Res; 2010 Sep 20; 165(7):557-64. PubMed ID: 20015628
    [Abstract] [Full Text] [Related]

  • 37. New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis.
    Eichner S, Floss HG, Sasse F, Kirschning A.
    Chembiochem; 2009 Jul 20; 10(11):1801-5. PubMed ID: 19554593
    [No Abstract] [Full Text] [Related]

  • 38. Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.
    Onuoha SC, Mukund SR, Coulstock ET, Sengerovà B, Shaw J, McLaughlin SH, Jackson SE.
    J Mol Biol; 2007 Sep 14; 372(2):287-97. PubMed ID: 17662999
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  • 40. A pair of sulfur-containing geldanamycin analogs, 19-S-methylgeldanamycin and 4,5-dihydro- 19-S-methylgeldanamycin, from Streptomyces hygroscopicus 17997.
    Liu X, Li J, Ni S, Wu L, Wang H, Lin L, He W, Wang Y.
    J Antibiot (Tokyo); 2011 Jul 14; 64(7):519-22. PubMed ID: 21559026
    [No Abstract] [Full Text] [Related]

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