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Journal Abstract Search

135 related items for PubMed ID: 21682257

  • 1. Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.
    Smith CJ, Ali A, Hammond ML, Li H, Lu Z, Napolitano J, Taylor GE, Thompson CF, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Cumiskey AM, Latham M, Peterson LB, Rosa R, Pivnichny JV, Tong X, Xu SS, Sinclair PJ.
    J Med Chem; 2011 Jul 14; 54(13):4880-95. PubMed ID: 21682257
    [Abstract] [Full Text] [Related]

  • 2. SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
    Lu Z, Chen YH, Napolitano JB, Taylor G, Ali A, Hammond ML, Deng Q, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):199-203. PubMed ID: 22142541
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib.
    Johns DG, Chen Y, Wang SP, Castro-Perez J, Previs SF, Roddy TP.
    Eur J Pharmacol; 2015 Sep 05; 762():256-62. PubMed ID: 26049012
    [Abstract] [Full Text] [Related]

  • 4. Anacetrapib, a cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis.
    Masson D.
    Curr Opin Investig Drugs; 2009 Sep 05; 10(9):980-7. PubMed ID: 19705341
    [Abstract] [Full Text] [Related]

  • 5. Anacetrapib: hope for CETP inhibitors?
    Gurfinkel R, Joy TR.
    Cardiovasc Ther; 2011 Oct 05; 29(5):327-39. PubMed ID: 20406242
    [Abstract] [Full Text] [Related]

  • 6. Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.
    Reinhard EJ, Wang JL, Durley RC, Fobian YM, Grapperhaus ML, Hickory BS, Massa MA, Norton MB, Promo MA, Tollefson MB, Vernier WF, Connolly DT, Witherbee BJ, Melton MA, Regina KJ, Smith ME, Sikorski JA.
    J Med Chem; 2003 May 22; 46(11):2152-68. PubMed ID: 12747787
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  • 9. 2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.
    Kallashi F, Kim D, Kowalchick J, Park YJ, Hunt JA, Ali A, Smith CJ, Hammond ML, Pivnichny JV, Tong X, Xu SS, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Cumiskey AM, Latham M, Peterson LB, Rosa R, Sparrow CP, Wright SD, Sinclair PJ.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):558-61. PubMed ID: 21094047
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  • 10. 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.
    Sweis RF, Hunt JA, Kallashi F, Hammond ML, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Cumiskey AM, Latham M, Rosa R, Peterson L, Sparrow CP, Wright SD, Anderson MS, Sinclair PJ.
    Bioorg Med Chem Lett; 2011 Mar 15; 21(6):1890-5. PubMed ID: 21147531
    [Abstract] [Full Text] [Related]

  • 11. Cholesteryl ester transfer protein inhibition enhances endothelial repair and improves endothelial function in the rabbit.
    Wu BJ, Shrestha S, Ong KL, Johns D, Hou L, Barter PJ, Rye KA.
    Arterioscler Thromb Vasc Biol; 2015 Mar 15; 35(3):628-36. PubMed ID: 25633313
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  • 13. Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.
    Krishna R, Bergman AJ, Jin B, Fallon M, Cote J, Van Hoydonck P, Laethem T, Gendrano IN, Van Dyck K, Hilliard D, Laterza O, Snyder K, Chavez-Eng C, Lutz R, Chen J, Bloomfield DM, De Smet M, Van Bortel LM, Gutierrez M, Al-Huniti N, Dykstra K, Gottesdiener KM, Wagner JA.
    Clin Pharmacol Ther; 2008 Dec 15; 84(6):679-83. PubMed ID: 18580870
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  • 15. Assessment of the CYP3A-mediated drug interaction potential of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy volunteers.
    Krishna R, Bergman AJ, Jin B, Garg A, Roadcap B, Chiou R, Dru J, Cote J, Laethem T, Wang RW, Didolkar V, Vets E, Gottesdiener K, Wagner JA.
    J Clin Pharmacol; 2009 Jan 15; 49(1):80-7. PubMed ID: 19004846
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  • 16. The development of fatty liver is accelerated in transgenic mice expressing cynomolgus monkey cholesteryl ester transfer protein.
    Blake WL, Ulrich RG, Marotti KR, Melchior GW.
    Biochem Biophys Res Commun; 1994 Dec 15; 205(2):1257-63. PubMed ID: 7802658
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  • 18. [HDL and CETP in atherogenesis].
    Pöss J, Böhm M, Laufs U.
    Dtsch Med Wochenschr; 2010 Feb 15; 135(5):188-92. PubMed ID: 20082258
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