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Journal Abstract Search

186 related items for PubMed ID: 21687502

  • 1. Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo.
    Koeberle A, Rossi A, Bauer J, Dehm F, Verotta L, Northoff H, Sautebin L, Werz O.
    Front Pharmacol; 2011; 2():7. PubMed ID: 21687502
    [Abstract] [Full Text] [Related]

  • 2. The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
    Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.
    J Pharmacol Exp Ther; 2010 Mar; 332(3):840-8. PubMed ID: 19934399
    [Abstract] [Full Text] [Related]

  • 3. Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1.
    Koeberle A, Pollastro F, Northoff H, Werz O.
    Br J Pharmacol; 2009 Mar; 156(6):952-61. PubMed ID: 19298395
    [Abstract] [Full Text] [Related]

  • 4. Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
    Koeberle A, Siemoneit U, Bühring U, Northoff H, Laufer S, Albrecht W, Werz O.
    J Pharmacol Exp Ther; 2008 Sep; 326(3):975-82. PubMed ID: 18550688
    [Abstract] [Full Text] [Related]

  • 5. Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.
    Koeberle A, Bauer J, Verhoff M, Hoffmann M, Northoff H, Werz O.
    Biochem Biophys Res Commun; 2009 Oct 16; 388(2):350-4. PubMed ID: 19665000
    [Abstract] [Full Text] [Related]

  • 6. Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.
    Bauer J, Kuehnl S, Rollinger JM, Scherer O, Northoff H, Stuppner H, Werz O, Koeberle A.
    J Pharmacol Exp Ther; 2012 Jul 16; 342(1):169-76. PubMed ID: 22511203
    [Abstract] [Full Text] [Related]

  • 7. Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1.
    Guay J, Bateman K, Gordon R, Mancini J, Riendeau D.
    J Biol Chem; 2004 Jun 04; 279(23):24866-72. PubMed ID: 15044444
    [Abstract] [Full Text] [Related]

  • 8. Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
    Koeberle A, Northoff H, Werz O.
    Mol Cancer Ther; 2009 Aug 04; 8(8):2348-55. PubMed ID: 19671757
    [Abstract] [Full Text] [Related]

  • 9. Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.
    Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML, Patrignani P.
    Biochem Pharmacol; 2010 Apr 01; 79(7):974-81. PubMed ID: 19925781
    [Abstract] [Full Text] [Related]

  • 10. Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo.
    Bauer J, Koeberle A, Dehm F, Pollastro F, Appendino G, Northoff H, Rossi A, Sautebin L, Werz O.
    Biochem Pharmacol; 2011 Jan 15; 81(2):259-68. PubMed ID: 20933508
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.
    Siemoneit U, Koeberle A, Rossi A, Dehm F, Verhoff M, Reckel S, Maier TJ, Jauch J, Northoff H, Bernhard F, Doetsch V, Sautebin L, Werz O.
    Br J Pharmacol; 2011 Jan 15; 162(1):147-62. PubMed ID: 20840544
    [Abstract] [Full Text] [Related]

  • 12. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.
    Koeberle A, Northoff H, Werz O.
    Biochem Pharmacol; 2009 May 01; 77(9):1513-21. PubMed ID: 19426689
    [Abstract] [Full Text] [Related]

  • 13. Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
    Schaible AM, Traber H, Temml V, Noha SM, Filosa R, Peduto A, Weinigel C, Barz D, Schuster D, Werz O.
    Biochem Pharmacol; 2013 Aug 15; 86(4):476-86. PubMed ID: 23623753
    [Abstract] [Full Text] [Related]

  • 14. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
    Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.
    Biochem Pharmacol; 2010 May 15; 79(10):1445-54. PubMed ID: 20067770
    [Abstract] [Full Text] [Related]

  • 15. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.
    Albert D, Zündorf I, Dingermann T, Müller WE, Steinhilber D, Werz O.
    Biochem Pharmacol; 2002 Dec 15; 64(12):1767-75. PubMed ID: 12445866
    [Abstract] [Full Text] [Related]

  • 16. Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
    Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O.
    Bioorg Med Chem; 2009 Dec 01; 17(23):7924-32. PubMed ID: 19884011
    [Abstract] [Full Text] [Related]

  • 17. Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review.
    Koeberle A, Werz O.
    Curr Med Chem; 2009 Dec 01; 16(32):4274-96. PubMed ID: 19754418
    [Abstract] [Full Text] [Related]

  • 18. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.
    Claveau D, Sirinyan M, Guay J, Gordon R, Chan CC, Bureau Y, Riendeau D, Mancini JA.
    J Immunol; 2003 May 01; 170(9):4738-44. PubMed ID: 12707354
    [Abstract] [Full Text] [Related]

  • 19. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content.
    Chrubasik-Hausmann S, Vlachojannis J, McLachlan AJ.
    J Pharm Pharmacol; 2019 Jan 01; 71(1):129-138. PubMed ID: 29411879
    [Abstract] [Full Text] [Related]

  • 20. Membrane prostaglandin E synthase-1: a novel therapeutic target.
    Samuelsson B, Morgenstern R, Jakobsson PJ.
    Pharmacol Rev; 2007 Sep 01; 59(3):207-24. PubMed ID: 17878511
    [Abstract] [Full Text] [Related]

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