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280 related items for PubMed ID: 21693539

  • 1. Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
    Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL.
    Carcinogenesis; 2011 Sep; 32(9):1315-23. PubMed ID: 21693539
    [Abstract] [Full Text] [Related]

  • 2. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.
    Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.
    Chem Biol Interact; 2010 Aug 05; 186(3):255-66. PubMed ID: 20570586
    [Abstract] [Full Text] [Related]

  • 3. Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.
    Sundar SN, Kerekatte V, Equinozio CN, Doan VB, Bjeldanes LF, Firestone GL.
    Mol Endocrinol; 2006 Dec 05; 20(12):3070-82. PubMed ID: 16901971
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  • 4. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.
    Marconett CN, Singhal AK, Sundar SN, Firestone GL.
    Mol Cell Endocrinol; 2012 Nov 05; 363(1-2):74-84. PubMed ID: 22835548
    [Abstract] [Full Text] [Related]

  • 5. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
    Cram EJ, Liu BD, Bjeldanes LF, Firestone GL.
    J Biol Chem; 2001 Jun 22; 276(25):22332-40. PubMed ID: 11297539
    [Abstract] [Full Text] [Related]

  • 6. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.
    Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF, Firestone GL.
    J Biol Chem; 1998 Feb 13; 273(7):3838-47. PubMed ID: 9461564
    [Abstract] [Full Text] [Related]

  • 7. N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.
    Jump SM, Kung J, Staub R, Kinseth MA, Cram EJ, Yudina LN, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.
    Biochem Pharmacol; 2008 Feb 01; 75(3):713-24. PubMed ID: 18023427
    [Abstract] [Full Text] [Related]

  • 8. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
    Firestone GL, Bjeldanes LF.
    J Nutr; 2003 Jul 01; 133(7 Suppl):2448S-2455S. PubMed ID: 12840223
    [Abstract] [Full Text] [Related]

  • 9. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression.
    Hong C, Kim HA, Firestone GL, Bjeldanes LF.
    Carcinogenesis; 2002 Aug 01; 23(8):1297-305. PubMed ID: 12151347
    [Abstract] [Full Text] [Related]

  • 10. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells.
    Zhang J, Hsu B A JC, Kinseth B A MA, Bjeldanes LF, Firestone GL.
    Cancer; 2003 Dec 01; 98(11):2511-20. PubMed ID: 14635088
    [Abstract] [Full Text] [Related]

  • 11. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
    Hsu JC, Zhang J, Dev A, Wing A, Bjeldanes LF, Firestone GL.
    Carcinogenesis; 2005 Nov 01; 26(11):1896-904. PubMed ID: 15958518
    [Abstract] [Full Text] [Related]

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  • 14. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.
    Oncogene; 2001 May 24; 20(23):2927-36. PubMed ID: 11420705
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  • 16. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.
    Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, Firestone GL.
    Cancer Res; 1999 Mar 15; 59(6):1244-51. PubMed ID: 10096555
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  • 18. Indole-3-carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells.
    Hung WC, Chang HC.
    J Agric Food Chem; 2009 Jan 14; 57(1):76-82. PubMed ID: 19061309
    [Abstract] [Full Text] [Related]

  • 19. Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells.
    Meng Q, Yuan F, Goldberg ID, Rosen EM, Auborn K, Fan S.
    J Nutr; 2000 Dec 14; 130(12):2927-31. PubMed ID: 11110848
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