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225 related items for PubMed ID: 21707864

  • 1. EW-7203, a novel small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor/activin receptor-like kinase-5, blocks TGF-β1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells.
    Park CY, Kim DK, Sheen YY.
    Cancer Sci; 2011 Oct; 102(10):1889-96. PubMed ID: 21707864
    [Abstract] [Full Text] [Related]

  • 2. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung.
    Park CY, Son JY, Jin CH, Nam JS, Kim DK, Sheen YY.
    Eur J Cancer; 2011 Nov; 47(17):2642-53. PubMed ID: 21852112
    [Abstract] [Full Text] [Related]

  • 3. An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition.
    Park CY, Min KN, Son JY, Park SY, Nam JS, Kim DK, Sheen YY.
    Cancer Lett; 2014 Aug 28; 351(1):72-80. PubMed ID: 24887560
    [Abstract] [Full Text] [Related]

  • 4. EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis.
    Son JY, Park SY, Kim SJ, Lee SJ, Park SA, Kim MJ, Kim SW, Kim DK, Nam JS, Sheen YY.
    Mol Cancer Ther; 2014 Jul 28; 13(7):1704-16. PubMed ID: 24817629
    [Abstract] [Full Text] [Related]

  • 5. A Small Dibromotyrosine Derivative Purified From Pseudoceratina Sp. Suppresses TGF-β Responsiveness by Inhibiting TGF-β Type I Receptor Serine/Threonine Kinase Activity.
    Chen CL, Kao YC, Yang PH, Sung PJ, Wen ZH, Chen JJ, Huang YB, Chen PY.
    J Cell Biochem; 2016 Dec 28; 117(12):2800-2814. PubMed ID: 27153151
    [Abstract] [Full Text] [Related]

  • 6. BIX02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor.
    Park SJ, Choi YS, Lee S, Lee YJ, Hong S, Han S, Kim BC.
    Cancer Lett; 2016 Oct 28; 381(2):314-22. PubMed ID: 27543359
    [Abstract] [Full Text] [Related]

  • 7. Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II.
    Maeda M, Shintani Y, Wheelock MJ, Johnson KR.
    J Biol Chem; 2006 Jan 06; 281(1):59-68. PubMed ID: 16267045
    [Abstract] [Full Text] [Related]

  • 8. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
    Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P.
    J Cell Sci; 1999 Dec 06; 112 ( Pt 24)():4557-68. PubMed ID: 10574705
    [Abstract] [Full Text] [Related]

  • 9. Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells.
    Park SY, Kim MJ, Park SA, Kim JS, Min KN, Kim DK, Lim W, Nam JS, Sheen YY.
    Oncotarget; 2015 Nov 10; 6(35):37526-43. PubMed ID: 26462028
    [Abstract] [Full Text] [Related]

  • 10. Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility.
    Ueda Y, Wang S, Dumont N, Yi JY, Koh Y, Arteaga CL.
    J Biol Chem; 2004 Jun 04; 279(23):24505-13. PubMed ID: 15044465
    [Abstract] [Full Text] [Related]

  • 11. Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells.
    Shinto O, Yashiro M, Kawajiri H, Shimizu K, Shimizu T, Miwa A, Hirakawa K.
    Br J Cancer; 2010 Mar 02; 102(5):844-51. PubMed ID: 20145621
    [Abstract] [Full Text] [Related]

  • 12. EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling.
    Park SA, Kim MJ, Park SY, Kim JS, Lee SJ, Woo HA, Kim DK, Nam JS, Sheen YY.
    Cell Mol Life Sci; 2015 May 02; 72(10):2023-39. PubMed ID: 25487606
    [Abstract] [Full Text] [Related]

  • 13. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta.
    Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K, Node M, Imamura T.
    Cancer Sci; 2005 Nov 02; 96(11):791-800. PubMed ID: 16271073
    [Abstract] [Full Text] [Related]

  • 14. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling.
    Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA, Watabe T, Sato Y.
    Cancer Sci; 2017 Mar 02; 108(3):419-426. PubMed ID: 28064471
    [Abstract] [Full Text] [Related]

  • 15. Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.
    Wendt MK, Schiemann WP.
    Breast Cancer Res; 2009 Mar 02; 11(5):R68. PubMed ID: 19740433
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
    Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA.
    Mol Pharmacol; 2002 Jul 02; 62(1):58-64. PubMed ID: 12065755
    [Abstract] [Full Text] [Related]

  • 17. TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition.
    Kim MJ, Park SA, Kim CH, Park SY, Kim JS, Kim DK, Nam JS, Sheen YY.
    Cell Physiol Biochem; 2016 Jul 02; 38(2):571-88. PubMed ID: 26845171
    [Abstract] [Full Text] [Related]

  • 18. An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.
    Rausch MP, Hahn T, Ramanathapuram L, Bradley-Dunlop D, Mahadevan D, Mercado-Pimentel ME, Runyan RB, Besselsen DG, Zhang X, Cheung HK, Lee WC, Ling LE, Akporiaye ET.
    Anticancer Res; 2009 Jun 02; 29(6):2099-109. PubMed ID: 19528470
    [Abstract] [Full Text] [Related]

  • 19. Chinese medicine Bu-Fei decoction attenuates epithelial-mesenchymal transition of non-small cell lung cancer via inhibition of transforming growth factor β1 signaling pathway in vitro and in vivo.
    He XR, Han SY, Li XH, Zheng WX, Pang LN, Jiang ST, Li PP.
    J Ethnopharmacol; 2017 May 23; 204():45-57. PubMed ID: 28412214
    [Abstract] [Full Text] [Related]

  • 20. Curcumin inhibits transforming growth factor-β1-induced EMT via PPARγ pathway, not Smad pathway in renal tubular epithelial cells.
    Li R, Wang Y, Liu Y, Chen Q, Fu W, Wang H, Cai H, Peng W, Zhang X.
    PLoS One; 2013 May 23; 8(3):e58848. PubMed ID: 23544048
    [Abstract] [Full Text] [Related]

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