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Journal Abstract Search

271 related items for PubMed ID: 21718305

  • 1. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor.
    Bertini R, Barcelos LS, Beccari AR, Cavalieri B, Moriconi A, Bizzarri C, Di Benedetto P, Di Giacinto C, Gloaguen I, Galliera E, Corsi MM, Russo RC, Andrade SP, Cesta MC, Nano G, Aramini A, Cutrin JC, Locati M, Allegretti M, Teixeira MM.
    Br J Pharmacol; 2012 Jan; 165(2):436-54. PubMed ID: 21718305
    [Abstract] [Full Text] [Related]

  • 2. Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice.
    Cunha TM, Barsante MM, Guerrero AT, Verri WA, Ferreira SH, Coelho FM, Bertini R, Di Giacinto C, Allegretti M, Cunha FQ, Teixeira MM.
    Br J Pharmacol; 2008 May; 154(2):460-70. PubMed ID: 18362895
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  • 4. A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.
    Chapman RW, Minnicozzi M, Celly CS, Phillips JE, Kung TT, Hipkin RW, Fan X, Rindgen D, Deno G, Bond R, Gonsiorek W, Billah MM, Fine JS, Hey JA.
    J Pharmacol Exp Ther; 2007 Aug; 322(2):486-93. PubMed ID: 17496165
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  • 5. Development of a systemically-active dual CXCR1/CXCR2 allosteric inhibitor and its efficacy in a model of transient cerebral ischemia in the rat.
    Garau A, Bertini R, Mosca M, Bizzarri C, Anacardio R, Triulzi S, Allegretti M, Ghezzi P, Villa P.
    Eur Cytokine Netw; 2006 Mar; 17(1):35-41. PubMed ID: 16613761
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  • 8. Combined anti CXC receptors 1 and 2 therapy is a promising anti-inflammatory treatment for respiratory diseases by reducing neutrophil migration and activation.
    Planagumà A, Domènech T, Pont M, Calama E, García-González V, López R, Aulí M, López M, Fonquerna S, Ramos I, de Alba J, Nueda A, Prats N, Segarra V, Miralpeix M, Lehner MD.
    Pulm Pharmacol Ther; 2015 Oct; 34():37-45. PubMed ID: 26271598
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  • 9. Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2.
    Casilli F, Bianchini A, Gloaguen I, Biordi L, Alesse E, Festuccia C, Cavalieri B, Strippoli R, Cervellera MN, Di Bitondo R, Ferretti E, Mainiero F, Bizzarri C, Colotta F, Bertini R.
    Biochem Pharmacol; 2005 Feb 01; 69(3):385-94. PubMed ID: 15652230
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  • 10. Actin filaments are involved in the regulation of trafficking of two closely related chemokine receptors, CXCR1 and CXCR2.
    Zaslaver A, Feniger-Barish R, Ben-Baruch A.
    J Immunol; 2001 Jan 15; 166(2):1272-84. PubMed ID: 11145710
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  • 11. Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats.
    Barsante MM, Cunha TM, Allegretti M, Cattani F, Policani F, Bizzarri C, Tafuri WL, Poole S, Cunha FQ, Bertini R, Teixeira MM.
    Br J Pharmacol; 2008 Mar 15; 153(5):992-1002. PubMed ID: 17891165
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  • 12. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2.
    Moriconi A, Cesta MC, Cervellera MN, Aramini A, Coniglio S, Colagioia S, Beccari AR, Bizzarri C, Cavicchia MR, Locati M, Galliera E, Di Benedetto P, Vigilante P, Bertini R, Allegretti M.
    J Med Chem; 2007 Aug 23; 50(17):3984-4002. PubMed ID: 17665889
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  • 14. CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.
    Clarke C, Kuboki S, Sakai N, Kasten KR, Tevar AD, Schuster R, Blanchard J, Caldwell CC, Edwards MJ, Lentsch AB.
    Hepatology; 2011 Jan 23; 53(1):261-71. PubMed ID: 21254176
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  • 16. The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.
    Cui S, Qiao L, Yu S, Men L, Li Y, Li F, Du J.
    Am J Physiol Endocrinol Metab; 2019 Dec 01; 317(6):E1205-E1217. PubMed ID: 31573846
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  • 17. Neutrophil recruitment in the reperfused-injured rat liver was effectively attenuated by repertaxin, a novel allosteric noncompetitive inhibitor of CXCL8 receptors: a therapeutic approach for the treatment of post-ischemic hepatic syndromes.
    Cavalieri B, Mosca M, Ramadori P, Perrelli MG, De Simone L, Colotta F, Bertini R, Poli G, Cutrìn JC.
    Int J Immunopathol Pharmacol; 2005 Dec 01; 18(3):475-86. PubMed ID: 16164828
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  • 18. IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways.
    Schraufstatter IU, Chung J, Burger M.
    Am J Physiol Lung Cell Mol Physiol; 2001 Jun 01; 280(6):L1094-103. PubMed ID: 11350788
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  • 19. Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha-mediated regulation of CXCR1 and CXCR2 chemokine receptor expression.
    Khandaker MH, Mitchell G, Xu L, Andrews JD, Singh R, Leung H, Madrenas J, Ferguson SS, Feldman RD, Kelvin DJ.
    Blood; 1999 Apr 01; 93(7):2173-85. PubMed ID: 10090924
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  • 20. CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
    Khan MN, Wang B, Wei J, Zhang Y, Li Q, Luan X, Cheng JW, Gordon JR, Li F, Liu H.
    Oncotarget; 2015 Aug 28; 6(25):21315-27. PubMed ID: 26087179
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