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Journal Abstract Search

210 related items for PubMed ID: 21719282

  • 1.
    ; . PubMed ID:
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  • 2. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides.
    Gu W, Wang T, Maltais F, Ledford B, Kennedy J, Wei Y, Gross CH, Parsons J, Duncan L, Arends SJ, Moody C, Perola E, Green J, Charifson PS.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3693-8. PubMed ID: 22560473
    [Abstract] [Full Text] [Related]

  • 3. The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds.
    Jahić H, Liu CF, Thresher J, Livchak S, Wang H, Ehmann DE.
    Biochem Pharmacol; 2012 Sep 01; 84(5):654-60. PubMed ID: 22743594
    [Abstract] [Full Text] [Related]

  • 4. Discovery of bacterial NAD⁺-dependent DNA ligase inhibitors: improvements in clearance of adenosine series.
    Stokes SS, Gowravaram M, Huynh H, Lu M, Mullen GB, Chen B, Albert R, O'Shea TJ, Rooney MT, Hu H, Newman JV, Mills SD.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):85-9. PubMed ID: 22154350
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
    Wang T, Duncan L, Gu W, O'Dowd H, Wei Y, Perola E, Parsons J, Gross CH, Moody CS, Arends SJ, Charifson PS.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3699-703. PubMed ID: 22560470
    [Abstract] [Full Text] [Related]

  • 6. Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
    Murphy-Benenato KE, Gingipalli L, Boriack-Sjodin PA, Martinez-Botella G, Carcanague D, Eyermann CJ, Gowravaram M, Harang J, Hale MR, Ioannidis G, Jahic H, Johnstone M, Kutschke A, Laganas VA, Loch JT, Miller MD, Oguto H, Patel SJ.
    Bioorg Med Chem Lett; 2015 Nov 15; 25(22):5172-7. PubMed ID: 26463129
    [Abstract] [Full Text] [Related]

  • 7. Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
    Ronkin SM, Badia M, Bellon S, Grillot AL, Gross CH, Grossman TH, Mani N, Parsons JD, Stamos D, Trudeau M, Wei Y, Charifson PS.
    Bioorg Med Chem Lett; 2010 May 01; 20(9):2828-31. PubMed ID: 20356737
    [Abstract] [Full Text] [Related]

  • 8. Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.
    Sherer BA, Hull K, Green O, Basarab G, Hauck S, Hill P, Loch JT, Mullen G, Bist S, Bryant J, Boriack-Sjodin A, Read J, DeGrace N, Uria-Nickelsen M, Illingworth RN, Eakin AE.
    Bioorg Med Chem Lett; 2011 Dec 15; 21(24):7416-20. PubMed ID: 22041057
    [Abstract] [Full Text] [Related]

  • 9. 4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.
    Xiao ZP, Ouyang H, Wang XD, Lv PC, Huang ZJ, Yu SR, Yi TF, Yang YL, Zhu HL.
    Bioorg Med Chem; 2011 Jul 01; 19(13):3884-91. PubMed ID: 21669535
    [Abstract] [Full Text] [Related]

  • 10. Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.
    Manchester JI, Dussault DD, Rose JA, Boriack-Sjodin PA, Uria-Nickelsen M, Ioannidis G, Bist S, Fleming P, Hull KG.
    Bioorg Med Chem Lett; 2012 Aug 01; 22(15):5150-6. PubMed ID: 22814212
    [Abstract] [Full Text] [Related]

  • 11. Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases.
    Meier TI, Yan D, Peery RB, McAllister KA, Zook C, Peng SB, Zhao G.
    FEBS J; 2008 Nov 01; 275(21):5258-71. PubMed ID: 18795946
    [Abstract] [Full Text] [Related]

  • 12. Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
    Surivet JP, Lange R, Hubschwerlen C, Keck W, Specklin JL, Ritz D, Bur D, Locher H, Seiler P, Strasser DS, Prade L, Kohl C, Schmitt C, Chapoux G, Ilhan E, Ekambaram N, Athanasiou A, Knezevic A, Sabato D, Chambovey A, Gaertner M, Enderlin M, Boehme M, Sippel V, Wyss P.
    Bioorg Med Chem Lett; 2012 Nov 01; 22(21):6705-11. PubMed ID: 23006603
    [Abstract] [Full Text] [Related]

  • 13. Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
    Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS.
    Antimicrob Agents Chemother; 2011 Mar 01; 55(3):1088-96. PubMed ID: 21189350
    [Abstract] [Full Text] [Related]

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  • 16. Discovery and Optimization of NAD+-Dependent DNA Ligase Inhibitors as Novel Antibacterial Compounds.
    Bi F, Ma R, Ma S.
    Curr Pharm Des; 2017 Mar 01; 23(14):2117-2130. PubMed ID: 27784238
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.
    Sink R, Kovac A, Tomasić T, Rupnik V, Boniface A, Bostock J, Chopra I, Blanot D, Masic LP, Gobec S, Zega A.
    ChemMedChem; 2008 Sep 01; 3(9):1362-70. PubMed ID: 18651694
    [Abstract] [Full Text] [Related]

  • 18. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.
    Seefeld MA, Miller WH, Newlander KA, Burgess WJ, DeWolf WE, Elkins PA, Head MS, Jakas DR, Janson CA, Keller PM, Manley PJ, Moore TD, Payne DJ, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Uzinskas IN, Wallis NG, Huffman WF.
    J Med Chem; 2003 Apr 24; 46(9):1627-35. PubMed ID: 12699381
    [Abstract] [Full Text] [Related]

  • 19. Adenosine analogs as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and antibacterial evaluation.
    Wei W, Shi WK, Wang PF, Zeng XT, Li P, Zhang JR, Li Q, Tang ZP, Peng J, Wu LZ, Xie MQ, Liu C, Li XH, Wang YC, Xiao ZP, Zhu HL.
    Bioorg Med Chem; 2015 Oct 15; 23(20):6602-11. PubMed ID: 26404408
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.
    Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S.
    Eur J Med Chem; 2014 Feb 12; 73():83-96. PubMed ID: 24384549
    [Abstract] [Full Text] [Related]

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