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162 related items for PubMed ID: 21724705

  • 1. Efficacy and safety of CH-1504, a metabolically stable antifolate, in patients with active rheumatoid arthritis: results of a phase II multicenter randomized study.
    Keystone EC, Shirinsky VS, Simon LS, Pedder S, Hewitt LA, CH-1504 Study Group.
    J Rheumatol; 2011 Sep; 38(9):1875-83. PubMed ID: 21724705
    [Abstract] [Full Text] [Related]

  • 2. Dose escalation of parenteral methotrexate in active rheumatoid arthritis that has been unresponsive to conventional doses of methotrexate: a randomized, controlled trial.
    Lambert CM, Sandhu S, Lochhead A, Hurst NP, McRorie E, Dhillon V.
    Arthritis Rheum; 2004 Feb; 50(2):364-71. PubMed ID: 14872477
    [Abstract] [Full Text] [Related]

  • 3. Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies.
    Khanna D, Park GS, Paulus HE, Simpson KM, Elashoff D, Cohen SB, Emery P, Dorrier C, Furst DE.
    Arthritis Rheum; 2005 Oct; 52(10):3030-8. PubMed ID: 16200612
    [Abstract] [Full Text] [Related]

  • 4. Controlled trial of methotrexate versus CH-1504 in the treatment of rheumatoid arthritis.
    Castaneda O, Nair MG.
    J Rheumatol; 2006 May; 33(5):862-4. PubMed ID: 16652417
    [Abstract] [Full Text] [Related]

  • 5. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis.
    Cohen SB, Cheng TT, Chindalore V, Damjanov N, Burgos-Vargas R, Delora P, Zimany K, Travers H, Caulfield JP.
    Arthritis Rheum; 2009 Feb; 60(2):335-44. PubMed ID: 19180516
    [Abstract] [Full Text] [Related]

  • 6. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial.
    Cohen S, Hurd E, Cush J, Schiff M, Weinblatt ME, Moreland LW, Kremer J, Bear MB, Rich WJ, McCabe D.
    Arthritis Rheum; 2002 Mar; 46(3):614-24. PubMed ID: 11920396
    [Abstract] [Full Text] [Related]

  • 7. Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group.
    Cohen S, Cannon GW, Schiff M, Weaver A, Fox R, Olsen N, Furst D, Sharp J, Moreland L, Caldwell J, Kaine J, Strand V.
    Arthritis Rheum; 2001 Sep; 44(9):1984-92. PubMed ID: 11592358
    [Abstract] [Full Text] [Related]

  • 8. CH-1504, a metabolically inert antifolate for the potential treatment of rheumatoid arthritis.
    Bajpai M.
    IDrugs; 2010 Aug; 13(8):559-67. PubMed ID: 20721827
    [Abstract] [Full Text] [Related]

  • 9. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial.
    Emery P, Fleischmann R, Filipowicz-Sosnowska A, Schechtman J, Szczepanski L, Kavanaugh A, Racewicz AJ, van Vollenhoven RF, Li NF, Agarwal S, Hessey EW, Shaw TM, DANCER Study Group.
    Arthritis Rheum; 2006 May; 54(5):1390-400. PubMed ID: 16649186
    [Abstract] [Full Text] [Related]

  • 10. Efficacy and safety of etanercept 50 mg twice a week in patients with rheumatoid arthritis who had a suboptimal response to etanercept 50 mg once a week: results of a multicenter, randomized, double-blind, active drug-controlled study.
    Weinblatt ME, Schiff MH, Ruderman EM, Bingham CO, Li J, Louie J, Furst DE.
    Arthritis Rheum; 2008 Jul; 58(7):1921-30. PubMed ID: 18576334
    [Abstract] [Full Text] [Related]

  • 11. Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate: a six-month, open-label study.
    Kremer JM, Habros JS, Kolba KS, Kaine JL, Borton MA, Mengle-Gaw LJ, Schwartz BD, Wisemandle W, Mekki QA, Tacrolimus-Methotrexate Rheumatoid Arthritis Study Group.
    Arthritis Rheum; 2003 Oct; 48(10):2763-8. PubMed ID: 14558080
    [Abstract] [Full Text] [Related]

  • 12. A 48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis: results of the METGO study.
    Lehman AJ, Esdaile JM, Klinkhoff AV, Grant E, Fitzgerald A, Canvin J, METGO Study Group.
    Arthritis Rheum; 2005 May; 52(5):1360-70. PubMed ID: 15880810
    [Abstract] [Full Text] [Related]

  • 13. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis.
    Zhang LL, Wei W, Xiao F, Xu JH, Bao CD, Ni LQ, Li XF.
    Arthritis Rheum; 2008 Jul 15; 59(7):905-10. PubMed ID: 18576295
    [Abstract] [Full Text] [Related]

  • 14. Comparison of two schedules for administering oral low-dose methotrexate (weekly versus every-other-week) in patients with rheumatoid arthritis in remission: a twenty-four week, single blind, randomized study.
    Luis M, Pacheco-Tena C, Cazarín-Barrientos J, Lino-Pérez L, Goycochea MV, Vazquez-Mellado J, Burgos-Vargas R.
    Arthritis Rheum; 1999 Oct 15; 42(10):2160-5. PubMed ID: 10524688
    [Abstract] [Full Text] [Related]

  • 15. Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate.
    Stock TC, Bloom BJ, Wei N, Ishaq S, Park W, Wang X, Gupta P, Mebus CA.
    J Rheumatol; 2012 Apr 15; 39(4):720-7. PubMed ID: 22382341
    [Abstract] [Full Text] [Related]

  • 16. Multicenter, randomized, double-blind, controlled trial of treatment of active rheumatoid arthritis with T-614 compared with methotrexate.
    Lu LJ, Bao CD, Dai M, Teng JL, Fan W, Du F, Yang NP, Zhao YH, Chen ZW, Xu JH, He PG, Wu HX, Tao Y, Zhang MJ, Han XH, Li XF, Gu JR, Li JH, Yu H.
    Arthritis Rheum; 2009 Jul 15; 61(7):979-87. PubMed ID: 19565542
    [Abstract] [Full Text] [Related]

  • 17. A randomized, double-blind, parallel, single-site pilot trial to compare two different starting doses of methotrexate in methotrexate-naïve adult patients with rheumatoid arthritis.
    Hobl EL, Mader RM, Jilma B, Duhm B, Mustak M, Bröll H, Högger P, Erlacher L.
    Clin Ther; 2012 May 15; 34(5):1195-203. PubMed ID: 22516039
    [Abstract] [Full Text] [Related]

  • 18. Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: a six-month, double-blind, randomized, dose-ranging study.
    Furst DE, Saag K, Fleischmann MR, Sherrer Y, Block JA, Schnitzer T, Rutstein J, Baldassare A, Kaine J, Calabrese L, Dietz F, Sack M, Senter RG, Wiesenhutter C, Schiff M, Stein CM, Satoi Y, Matsumoto A, Caldwell J, Harris RE, Moreland LW, Hurd E, Yocum D, Stamler DA.
    Arthritis Rheum; 2002 Aug 15; 46(8):2020-8. PubMed ID: 12209503
    [Abstract] [Full Text] [Related]

  • 19. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial.
    Braun J, Kästner P, Flaxenberg P, Währisch J, Hanke P, Demary W, von Hinüber U, Rockwitz K, Heitz W, Pichlmeier U, Guimbal-Schmolck C, Brandt A, MC-MTX.6/RH Study Group.
    Arthritis Rheum; 2008 Jan 15; 58(1):73-81. PubMed ID: 18163521
    [Abstract] [Full Text] [Related]

  • 20. Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy.
    Stamp LK, O'Donnell JL, Chapman PT, Zhang M, James J, Frampton C, Barclay ML.
    Arthritis Rheum; 2010 Feb 15; 62(2):359-68. PubMed ID: 20112376
    [Abstract] [Full Text] [Related]

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