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184 related items for PubMed ID: 21737619

  • 1. LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells.
    Liu A, Liu Y, Li PK, Li C, Lin J.
    Anticancer Res; 2011 Jun; 31(6):2029-35. PubMed ID: 21737619
    [Abstract] [Full Text] [Related]

  • 2. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
    Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J.
    Neoplasia; 2010 Jan; 12(1):39-50. PubMed ID: 20072652
    [Abstract] [Full Text] [Related]

  • 3. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.
    Lin L, Benson DM, DeAngelis S, Bakan CE, Li PK, Li C, Lin J.
    Int J Cancer; 2012 Mar 15; 130(6):1459-69. PubMed ID: 21520044
    [Abstract] [Full Text] [Related]

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  • 5. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.
    Liu Y, Li PK, Li C, Lin J.
    J Biol Chem; 2010 Aug 27; 285(35):27429-27439. PubMed ID: 20562100
    [Abstract] [Full Text] [Related]

  • 6. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells.
    Liu Y, Liu A, Li H, Li C, Lin J.
    Cancer Prev Res (Phila); 2011 Aug 27; 4(8):1296-305. PubMed ID: 21490132
    [Abstract] [Full Text] [Related]

  • 7. Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.
    Wei CC, Ball S, Lin L, Liu A, Fuchs JR, Li PK, Li C, Lin J.
    Int J Oncol; 2011 Jan 27; 38(1):279-85. PubMed ID: 21109950
    [Abstract] [Full Text] [Related]

  • 8. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.
    Slattery ML, Lundgreen A, Kadlubar SA, Bondurant KL, Wolff RK.
    Mol Carcinog; 2013 Feb 27; 52(2):155-66. PubMed ID: 22121102
    [Abstract] [Full Text] [Related]

  • 9. LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy.
    Zuo M, Li C, Lin J, Javle M.
    Oncotarget; 2015 May 10; 6(13):10940-9. PubMed ID: 25883212
    [Abstract] [Full Text] [Related]

  • 10. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells.
    Liu Y, Fuchs J, Li C, Lin J.
    Cell Cycle; 2010 Sep 01; 9(17):3423-7. PubMed ID: 20818158
    [Abstract] [Full Text] [Related]

  • 11. REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop.
    Liu X, Wang J, Wang H, Yin G, Liu Y, Lei X, Xiang M.
    Cancer Lett; 2015 Jun 28; 362(1):45-60. PubMed ID: 25779676
    [Abstract] [Full Text] [Related]

  • 12. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice.
    Onimoe GI, Liu A, Lin L, Wei CC, Schwartz EB, Bhasin D, Li C, Fuchs JR, Li PK, Houghton P, Termuhlen A, Gross T, Lin J.
    Invest New Drugs; 2012 Jun 28; 30(3):916-26. PubMed ID: 21340507
    [Abstract] [Full Text] [Related]

  • 13. A small molecule STAT3 inhibitor, LLL12, enhances cisplatin‑ and paclitaxel‑mediated inhibition of cell growth and migration in human ovarian cancer cells.
    Zhang R, Chen X, Fu S, Xu L, Lin J.
    Oncol Rep; 2020 Sep 28; 44(3):1224-1232. PubMed ID: 32705214
    [Abstract] [Full Text] [Related]

  • 14. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling.
    Song L, Rawal B, Nemeth JA, Haura EB.
    Mol Cancer Ther; 2011 Mar 28; 10(3):481-94. PubMed ID: 21216930
    [Abstract] [Full Text] [Related]

  • 15. Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3.
    Sun J, Du Y, Zhang X, Wang Z, Lin Y, Song Q, Wang X, Guo J, Li S, Nan J, Yang J.
    Invest New Drugs; 2020 Aug 28; 38(4):1003-1011. PubMed ID: 31612426
    [Abstract] [Full Text] [Related]

  • 16. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.
    Nam S, Wen W, Schroeder A, Herrmann A, Yu H, Cheng X, Merz KH, Eisenbrand G, Li H, Yuan YC, Jove R.
    Mol Oncol; 2013 Jun 28; 7(3):369-78. PubMed ID: 23206899
    [Abstract] [Full Text] [Related]

  • 17. 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.
    Wang Y, Ma X, Yan S, Shen S, Zhu H, Gu Y, Wang H, Qin G, Yu Q.
    Cancer Res; 2009 Sep 15; 69(18):7302-10. PubMed ID: 19706767
    [Abstract] [Full Text] [Related]

  • 18. Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells.
    Kim C, Kim JH, Oh EY, Nam D, Lee SG, Lee J, Kim SH, Shim BS, Ahn KS.
    Pancreas; 2016 Mar 15; 45(3):409-19. PubMed ID: 26646273
    [Abstract] [Full Text] [Related]

  • 19. Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
    Razidlo GL, Burton KM, McNiven MA.
    J Biol Chem; 2018 Jul 13; 293(28):11143-11153. PubMed ID: 29853638
    [Abstract] [Full Text] [Related]

  • 20. Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding.
    Sen B, Saigal B, Parikh N, Gallick G, Johnson FM.
    Cancer Res; 2009 Mar 01; 69(5):1958-65. PubMed ID: 19223541
    [Abstract] [Full Text] [Related]

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